Nisha S. Ninan

Assembly of higher-order SMN oligomers is essential for metazoan viability and requires an exposed structural motif present in the YG zipper dimer

Kushol Gupta, Ying Wen, Nisha S. Ninan, Amanda C. Raimer et autres

Protein oligomerization is one mechanism by which homogenous solutions can separate into distinct liquid phases, enabling assembly of membraneless organelles. Survival Motor Neuron (SMN) is the eponymous component of a large macromolecular complex that chaperones biogenesis of eukaryotic ribonucleoproteins and localizes to …

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Assembly of higher-order SMN oligomers is essential for metazoan viability and requires an exposed structural motif present in the YG zipper dimer

Kushol Gupta, Ying Wen, Nisha S. Ninan, Amanda C. Raimer et autres

Abstract Protein oligomerization is one mechanism by which homogenous solutions can separate into distinct liquid phases, enabling assembly of membraneless organelles. Survival Motor Neuron (SMN) is the eponymous component of a large macromolecular complex that chaperones biogenesis of eukaryotic ribonucleoproteins, and localizes …

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Oligomeric Properties of Survival Motor Neuron·Gemin2 Complexes

Kushol Gupta, Renée S. Martin, Robert B. Sharp, Kathryn Lorenz Sarachan et autres

The survival motor neuron (SMN) protein forms the oligomeric core of a multiprotein complex required for the assembly of spliceosomal small nuclear ribonucleoproteins. Deletions and mutations in the SMN1 gene are associated with spinal muscular atrophy (SMA), a devastating neurodegenerative disease that …

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Determinants of the SMN Tudor Domain Interaction with the RG-tail of SmD3

Nisha S. Ninan

The Survival of Motor Neurons protein (SMN) forms the core of a large protein complex termed the ‘SMN complex’. The primary characterized function of the SMN complex is to facilitate the specific assembly of seven Sm proteins onto uridine-rich small nuclear RNAs …

The Survival Motor Neuron Protein Forms Soluble Glycine Zipper Oligomers

Renée S. Martin, Kushol Gupta, Nisha S. Ninan, Kay Perry et autres

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Design and synthesis of polyethylene glycol-modified biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s

Nalin L. Subasinghe, Ehab M. Khalil, Jeremy M. Travins, Farah Ali et autres

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Biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s

Jeremy M. Travins, Farah Ali, Hui Huang, Shelley K. Ballentine et autres

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7-Fluoroindazoles as Potent and Selective Inhibitors of Factor Xa

Yu‐Kai Lee, Daniel J. Parks, Tianbao Lu, Tho V. Thieu et autres

We have developed a novel series of potent and selective factor Xa inhibitors that employ a key 7-fluoroindazolyl moiety. The 7-fluoro group on the indazole scaffold replaces the carbonyl group of an amide that is found in previously reported factor Xa inhibitors. …

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A novel series of arylsulfonylthiophene-2-carboxamidine inhibitors of the complement component C1s

Nalin L. Subasinghe, Jeremy M. Travins, Farah Ali, Hui Huang et autres

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Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors

Lei Qiao, Christian A. Baumann, Carl S. Crysler, Nisha S. Ninan et autres

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X-ray Structure of Novel Biaryl-Based Dipeptidyl peptidase IV inhibitor

Lei Qiao, Carsten Baumann, Carl S. Crysler, Nisha S. Ninan et autres

Overexpression, Purification, Characterization, and Crystallization of the BTB/POZ Domain from the PLZF Oncoprotein

Xinmin Li, Jesús M. López-Guisa, Nisha S. Ninan, Evan J. Weiner et autres

The BTB/POZ domain defines a conserved region of about 120 residues and has been found in over 40 proteins to date. It is located predominantly at the N terminus of Zn-finger DNA-binding proteins, where it may function as a repression domain, and …

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