Accès ouvert
2025
article
OpenAlex
Alicia María Tamayo Carbón, Ariana García Ojalvo, José I Fernández‐Montequín, William Savigne-Gutiérrez et autres
Chronic wounds are considered a silent epidemic that impact millions of human lives worldwide, causing comorbidities, reducing life quality and expectancy. Diabetic, pressure, and venous ulcers are the three major clinical entities of chronic wounds, in which the presence of a chronicity …
cu
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Accès ouvert
2022
review
OpenAlex
Jorge Berlanga‐Acosta, Jose Fernandez-Montequin, Héctor Santana-Milián, Calixto Valdes-Perez et autres
Diabetes mellitus remains as a pandemic disease, associated to progressive and irreversible complications including lower extremity ulcerations, derived from a predisposition to ischemia, neuropathy and an intrinsic wound healing failure. The molecular operators supporting wound chronicity remain elusive, but a local deficit …
cu, es
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Accès ouvert
2017
article
OpenAlex
Jorge Berlanga‐Acosta, José I Fernández‐Montequín, Calixto Valdés‐Perez, William Savigne-Gutiérrez et autres
Soon after epidermal growth factor (EGF) discovery, somein vivomodels appeared demonstrating its property to enhance cutaneous wound healing. EGF was the first growth factor (GF) introduced in the clinical arena as a healing enhancer, exerting its mitogenic effects on epithelial, fibroblastoid, and …
cu, il
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Accès ouvert
2012
article
OpenAlex
Jorge Berlanga‐Acosta, Ernesto López‐Mola, Marianela García-Siverio, Gerardo E Guillén et autres
Type 2 diabetes mellitus comprises a group of non-communicable metabolic diseases with an expanding pandemic magnitude. Diabetes predisposes to lower extremities ulceration and impairs the healing process leading to wounds chronification. Diabetes also dismantles innate immunity favoring wound infection. Amputation is therefore …
cu
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Accès ouvert
2010
article
OpenAlex
Jorge Berlanga‐Acosta, Calixto Valdéz-Pérez, William Savigne-Gutiérrez, Yssel Mendoza‐Marí et autres
Impaired healing in diabetes affects the resolution of both acute and chronic wounds. The vicious circle between wound chronicity and a deficient control of local infection is the cause that diabetic patients constitute 85% of all non-traumatic lower extremity amputations. From an …
cu
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Accès ouvert
2007
article
OpenAlex
José I Fernández‐Montequín, Ena Infante‐Cristiá, Carmen Valenzuela‐Silva, Neobalis Franco‐Pérez et autres
To investigate the efficacy and safety of recombinant human epidermal growth factor (rhEGF) in advanced diabetic foot ulcers (DFU) A double-blind trial was carried out to test two rhEGF dose levels in type 1 or 2 diabetes patients with Wagner's grade 3 …
cu
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