Zhiqiang Sun

Selective GLUT9 inhibitors for hyperuricemia via intestinal mechanism

Zean Zhao, Zhiqiang Sun, Zilin Shen, Fengxin Zheng et autres

This study reports the discovery of first-in-class selective glucose transporter 9 (GLUT9) inhibitors, with lead compounds SG4 and SG7 demonstrating high potency and target specificity, as evidenced by cryo-EM structural analysis at 3.14 Å resolution revealing key binding residues (Y71, E364, C427). …

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Daratumumab-based first-line therapy benefit multiple myeloma patients in a real-world setting: a multi-center retrospective propensity score-match study

Yun Wang, Xiaoqin Chen, Qi Liang, Weida Wang et autres

BACKGROUND: Adding daratumumab to initial therapy in randomized controlled trials (RCTs) for newly diagnosed multiple myeloma (MM) enhances deep remission and prolongs progression-free survival (PFS). Given the differences between trial-eligible and real-world patients, and healthcare access variability in developing countries, real-world data …

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Preparation, immunological and pharmacological effects of flavonoids in Scutellariae radix: a review

Haixia Chen, Yumin Wei, Jing Song, Yang Yue et autres

In traditional Chinese medicine theory, Scutellaria baicalensis Georgi [Lamiaceae; Scutellariae radix] (SR) is bitter and cold in nature. It enters the lung, gallbladder, spleen, large intestine, and small intestine meridians. It clears heat and dries dampness, purges fire and detoxifies, stops bleeding, …

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Discovery of PD-L1 inhibitors featuring novel indole and pyrrolopyridine scaffolds with PD-L1 degradation activity in vivo

Xuewen Zhang, Lirong Zhang, Zhiqiang Sun, Chenglong Xu et autres

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Enhanced selective removal of phosphonate pesticides by adsorption-catalytic oxidation synergy over MOF supported Mn-Fe3O4: Insights from DFT calculation and QSAR model

Weisheng Zheng, Zhaohua Liu, Zhou yang Wei, Jinyu Xu et autres

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Structure‐Driven α‐Fe 2 O 3 @Ag Nanohybrids Orchestrate Redox–Hormone–Metabolite Crosstalk for Plant Salt Stress Reprogramming

Yang Xu, Zhiqiang Sun, Panxin Wang, Qi Wang et autres

ABSTRACT Soil salinity is a critical abiotic stressor that disrupts plant growth by impairing redox balance, membrane stability, and metabolic coordination. While nanomaterials have emerged as promising abiotic stress modulators, the influence of nanoscale architecture on multi‐level plant responses remains insufficiently understood. …

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Effects of dietary net energy and fibre-degrading enzymes on growth performance and gut microbiota in growing-finishing pigs

Ge Zhang, Xing He, Zhiqiang Sun, Yuhan Guo et autres

This study aimed to evaluate the effects of dietary net energy (NE) and fibre-degrading enzymes on growth performance, nutrient digestibility, serum biochemical and inflammatory markers, faecal short-chain fatty acids （SCFA） and microbiota composition in growing-finishing pigs. A total of 192 crossbred pigs …

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Frustrated Lewis Pair-Mediated Catalyst Efficiency in ROMP: Mechanistic Insights from Boronic Ester-Functionalized Monomers

Sitong Feng, Xin Zhang, Yuanzhi Li, Feng Yu et autres

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Successful treatment of transplant-associated thrombotic microangiopathy with iptacopan: a non-adult case study

Shijie Bao, Kaikai Huang, Xiao Huang, Huamin Zhu et autres

Transplant-associated thrombotic microangiopathy (TA-TMA) is a severe complication of hematopoietic stem cell transplantation (HSCT), characterized by microangiopathic hemolytic anemia, thrombocytopenia, microthrombosis, and multi-organ dysfunction. Mortality rates range from 50% to 90%, with higher rates observed in high-risk patients. The pathogenesis of TA-TMA …

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Plant-Derived Bioactive Peptides: Extraction, Isolation, Purification, Pharmacological Activities, Structure–Activity Relationship, and Applications

Yanli Chen, Haixia Chen, Yue Yang, Jiayu Zhang et autres

Plant-derived bioactive peptides (PDBPs) have become a key research focus owing to their multiple targets and high safety. However, current challenges in this field primarily include the low efficiency of traditional extraction techniques, the complex structure-activity relationships of PDBPs, the scalability of …

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Research Progress on bioactive peptides from animal sources: A comprehensive review

Yanli Chen, Yue Yang, Haixia Chen, Jiayu Zhang et autres

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Discovery of novel Bis-amide analogue ST12 for the treatment of inflammatory bowel diseases (IBD) by inhibiting NLRP3 inflammasome activation

Zhiqiang Sun, Qinru Zang, Chenglong Xu, Xuewen Zhang et autres

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