Akbar Hajizadeh Moghaddam

Biofortification of Chlorella vulgaris With Selenium and Iron Microminerals and Investigation of Some Bioactive Compounds: A Promising Dietary Supplement

Masoumeh Rezaei Moshaei, M Azadbakht, Akbar Hajizadeh Moghaddam, Mahbobeh Ghanbarzadeh

ABSTRACT Microalgae are excellent bioaccumulators of selenium (Se) and iron (Fe), making them ideal for use in the fortification of food and feed supplements. This study aimed to investigate the effects of varying concentrations of Se and Fe on the growth of …

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Curcumin and nanocurcumin attenuate ethanol-induced cognitive and oxidative impairments in male rats

Mohammad Javad Ghobadi, Farhad Valizadegan, Akbar Hajizadeh Moghaddam, Sedigheh Khanjani Jelodar et autres

Chronic ethanol consumption induces oxidative stress, damaging hippocampal neurons and cognition. Curcumin (Curcuma longa) has antioxidant and anti-inflammatory actions; its nanoformulation (nanocurcumin) improves absorption and therapeutic efficacy. We evaluated curcumin and nanocurcumin for protection against ethanol-induced learning/memory deficits and hippocampal oxidative imbalance …

Curcumin and nanocurcumin attenuate ethanol-induced cognitive and oxidative impairments in male rats

Mohammad Javad Ghobadi, Farhad Valizadegan, Akbar Hajizadeh Moghaddam, Sedigheh Khanjani Jelodar et autres

Chronic ethanol consumption induces oxidative stress, damaging hippocampal neurons and cognition. Curcumin (Curcuma longa) has antioxidant and anti-inflammatory actions; its nanoformulation (nanocurcumin) improves absorption and therapeutic efficacy. We evaluated curcumin and nanocurcumin for protection against ethanol-induced learning/memory deficits and hippocampal oxidative imbalance …

Curcumin and nanocurcumin attenuate ethanol-induced cognitive and oxidative impairments in male rats

Mohammad Javad Ghobadi, Farhad Valizadegan, Akbar Hajizadeh Moghaddam, Sedigheh Khanjani Jelodar et autres

Chronic ethanol consumption induces oxidative stress, damaging hippocampal neurons and cognition. Curcumin (Curcuma longa) has antioxidant and anti-inflammatory actions; its nanoformulation (nanocurcumin) improves absorption and therapeutic efficacy. We evaluated curcumin and nanocurcumin for protection against ethanol-induced learning/memory deficits and hippocampal oxidative imbalance …

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Insulin resistance as a driver of neuroinflammation and oxidative stress in Alzheimer's disease: Mechanistic links and therapeutic approaches

Parinaz Hajeforoosh, Akbar Hajizadeh Moghaddam, Sedigheh Khanjani Jelodar

Alzheimer's disease (AD) is a complex, multifactorial neurodegenerative disorder characterized by the accumulation of amyloid-β plaques and hyperphosphorylated tau protein aggregates, leading to progressive cognitive decline. Growing evidence suggests that AD may also be considered a metabolic disorder closely associated with insulin …

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Preventive Effect of Gallic Acid‐Loaded Carrageenan Nanoparticles Against Cerebral Ischemia/Reperfusion Injury in Rat: Modulation of Oxidative Pathway

Akbar Hajizadeh Moghaddam, Parisa jahani bahnamiri, Sedigheh Khanjani Jelodar, Zohre Fendereski Jaz et autres

Polymeric nanocarriers represent a promising drug delivery platform for neurological disorders. This study evaluated the neuroprotective effects of gallic acid-loaded carrageenan nanoparticles (GA-CG NPs) in a rat model of global cerebral ischemia/reperfusion (I/R) injury. Rats were randomly assigned to four groups, including …

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Neuroprotective effects of plasma-activated N-acetylcysteine against streptozotocin-induced behavioral deficits in rats: Attenuation of oxidative stress and cholinergic dysfunction

Yasaman Firouzjaei, Akbar Hajizadeh Moghaddam, Farshad Sohabatzadeh, Sedigheh Khanjani Jelodar et autres

N-Acetylcysteine (NAC), a thiol-containing antioxidant, has demonstrated neuroprotective potential in various neurological disorders. Recently, cold atmospheric plasma (CAP) technology has emerged as a promising approach for modifying the physicochemical properties of biomolecules. This study investigated the neuroprotective effects of plasma-activated N-acetylcysteine (PAN) …

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Neuroprotective efficacy of methanolic extract of propolis against early life stress-induced oxidative and inflammatory damage: Involvement of the Nrf2–Keap1 signaling pathway

Ilia Ahmadi Kholardi, Akbar Hajizadeh Moghaddam, Mohammad Reza Bigdeli, Sedigheh Khanjani Jelodar

Background Early-life stress (ELS) is a major environmental risk factor for neurobehavioral impairments, including cognitive dysfunction, repetitive behaviors, and social deficits. Propolis, a natural bee product with strong antioxidant and anti-inflammatory properties, may counteract oxidative stress–related disorders. This study examined whether methanolic …

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Mitigation of fenvalerate-induced oxidative stress in the liver and brain by garlic extract and N-acetylcysteine in rats: a biochemical and histopathological study

Parisa Raji, Bagher Seyedalipour, Sahar Yaqubi, Seyed Mohammad Hosseini et autres

Fenvalerate (Fen), a pyrethroid pesticide, is widely used to control various pests. This study aimed to investigate the effects of garlic extract (GE) and N-acetylcysteine (NAC) on antioxidant enzyme activities and histopathological changes in the liver and brain tissues of rats exposed …

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Astaxanthin attenuates carrageenan-induced oxidative stress and inflammation in mice brain: possible role of the wnt/β-catenin signaling pathway

Seyed Reza Mokhtari Sangdehi, Akbar Hajizadeh Moghaddam, Sedigheh Khanjani Jelodar

Background Astaxanthin (AST) is a red pigment carotenoid with various pharmacological effects. It exerts powerful antioxidant and anti-inflammatory activities. However, there is still limited and sometimes contrasting data regarding the exact mechanism of AST in different inflammation models.Objective This study aimed to …

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Polystyrene nanoparticles and nano-silver: their co-influence on male fertility in mice

Parisa Ostadian, Fereshteh Mir Mohammadrezaei, Fatemeh Kardel, Akbar Hajizadeh Moghaddam

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Neuroprotective effects of nanophytosome-encapsulated citral in a mouse model of chronic unpredictable mild stress through the suppression of oxidative stress and inflammation

Mohammad Amin Mashayekhpour, Akbar Hajizadeh Moghaddam, Mohaddeseh Abouhosseini Tabari, Mojtaba Ranjbar

This study investigated the neuroprotective effects of nanophytosomal citral against chronic unpredictable mild stress (CUMS)-induced depression in mice, with exploration of potential mechanisms. Following six weeks of CUMS exposure, mice received either fluoxetine (20 mg/kg) or nanophytosomal citral (10, 20, or 50 …

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