Çağlar Köseoğlu

Comparison of 24 Versus 46-Hour 5-FU Infusion Durations in the Perioperative FLOT Therapy for Gastric Cancer

Savaş Gökçek, Pervin Can Sanci, Anıl Karakayalı, Emine Bihter Eniseler et autres

Background and Objectives: This study aimed to evaluate the effects of 24 h versus 46 h continuous 5-fluorouracil (5-FU) infusion durations on pathological response, progression-free survival (PFS), and overall survival (OS) in patients with gastric and gastroesophageal junction adenocarcinoma receiving a perioperative …

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Comparison of 6 cycles with 4 cycles of chemotherapy and atezolizumab in the first-line treatment of ES-SCLC: a retrospective multicenter analysis

Halil Göksel Güzel, D. Kivrak Salim, Saadettin Kılıçkap, Yasemi̇n Kemal et autres

AIM: IMpower133 was designed with 4 cycles of chemoimmunotherapy with atezolizumab, unlike many other studies permitted 6-cycle induction. This study aimed to compare the efficacy and safety of a 4-cycle regimen with an extended 6-cycle regimen of carboplatin, etoposide, and atezolizumab in …

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Prognostic Impact of Cetuximab-Related Hypomagnesemia and Hypokalemia in RAS/RAF Wild-Type Colorectal Cancer: A Multicenter Study

Halil Göksel Güzel, Derya Kıvrak Salim, Ece Ulukal Karancı, Mehmet Acun et autres

Purpose: The prognostic value of cetuximab-related electrolyte disturbances in metastatic colorectal cancer (CRC) remains unclear. The available reports on the prognostic effect of hypomagnesemia are controversial, while there are no comprehensive analyses regarding hypokalemia. This study aimed to evaluate the impact of …

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The Efficacy of High-Dose Chemotherapy Followed by Autologous Stem Cell Transplantation in Ewing Sarcoma Patients

Ömer Faruk Kuzu, Nuri Karadurmuş, Nebi Batuhan Kanat, Çağlar Köseoğlu et autres

Background: The role of high-dose chemotherapy followed by autologous stem-cell transplantation (HDCT–ASCT) in advanced Ewing sarcoma remains uncertain, with mixed prospective data and heterogeneous retrospective findings. Materials and Methods: We performed a single-center, retrospective cohort study of consecutive patients with histologically confirmed …

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The Impact of Clinical and Morphometric Parameters on Hematopoietic Engraftment Following High-Dose Chemotherapy and Autologous Stem Cell Transplantation in Germ Cell Tumors

Ömer Faruk Kuzu, Nuri Karadurmuş, Nebi Batuhan Kanat, Çağlar Köseoğlu et autres

Background and Objectives: Relapsed or refractory germ cell tumors are commonly treated with HDCT/ASCT, but robust predictors of hematopoietic recovery are limited. Quantitative CT-based metrics of body composition are readily available, but their prognostic value for post-transplant engraftment remains uncertain. We investigated …

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Comparison of First-Line FOLFOX versus FOLFIRI in RAS Mutant Metastatic Colorectal Cancer Patients

Alper Topal, Goncagül Akdağ, Aysegul Dumludag, Çağlar Köseoğlu et autres

disease will progress to the metastatic stage.[2][3][4] In metastatic patients, 5-year survival is less than 20%.5 For metastatic disease, the backbone of treatment is 5-fluorouracil (5-FU)-based regimens.These include 5-FU+irinotecan (FOLFIRI), capecitabine+oxaliplatin, and 5-FU+oxaliplatin (FOLFOX).6 In selected patients, triplet ABSTRACT Objective: Colorectal cancer …

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The Impact of Clinical and Morphometric Parameters on Hematopoietic Engraftment Following High-Dose Chemotherapy and Autologous Stem Cell Transplantation in Germ Cell Tumors

Ömer Faruk Kuzu, Nuri Karadurmuş, Nebi Batuhan Kanat, Çağlar Köseoğlu et autres

Background Relapsed or refractory Germ cell tumors are commonly treated with HDCT/ASCT, yet robust predictors of hematopoietic recovery are limited. Quantitative CT-based body-composition metrics are readily available in practice, but their prognostic value for post-transplant engraftment remains uncertain. We investigated whether muscle …

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Efficacy of Perioperative FLOT Therapy in Locally Advanced Gastric Cancer and the Associated Prognostic Factors

Gül Sema Yıldıran Keskin, İsmail ERTÜRK, Musa Barış AYKAN, Ramazan Acar et autres

Gastric cancer is one of the most common types of cancer.However, despite a significant decrease in the incidence of this cancer over the past two decades, it remains a leading cause of cancer-related deaths worldwide. 1Improved treatment strategies are, therefore, necessary as …

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Uncommon variants detected via hereditary cancer panel and suggestions for genetic counseling

Zeynep Tuğba Özdemir, Ezgi Çevik, Berna Çakmak Öksüzoğlu, Mutlu Doğan et autres

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Efficacy of Pazopanib in Patients with Pretreated Advanced Stage Soft Tissue Sarcomas

Musa Barış Aykan, Gül Sema Yıldıran Keskin, Ece Örnek, Alper Topal et autres

Background: Pazopanib acts as a multitargeted tyrosine kinase inhibitor.It has been shown to be effective in patients with advanced stage Soft Tissue Sarcomas (STSs).We aimed to evaluate survival times and significant side effects by making a retrospective evaluation of real-life data. Materials …

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