Eric Eunshik Kim

Comprehensive proteogenomic characterization reveals clinically relevant molecular subtypes associated with medulloblastoma progression

S Park, Seong-Min Park, Kyung-Hee Kim, Jong Hyuk Yoon et autres

Current treatment strategies for medulloblastoma remain ineffective owing to extensive tumor heterogeneity. We generated five platforms of omics data including liquid chromatography and mass spectrometry-based proteome and performed integrated multi-omic characterization to improve the conventional molecular classification of medulloblastoma. We identified seven …

kr, us, pr, ca, jp (code pays fourni par la source)

High-Grade Astrocytoma With Piloid Features: An Aggressive Clinicogenomic Entity Distinct From Pilocytic Astrocytoma

Jeongwan Kang, Eric Eunshik Kim, Kwanghoon Lee, Seong Ik Kim et autres

BACKGROUND: High-grade astrocytoma with piloid features (HGAP) has recently emerged as an aggressive glioma entity with distinct molecular alterations, yet its clinicogenomic distinction from pilocytic astrocytoma (PA) remains to be fully elucidated. This study aims to clarify the clinical, pathological, and genomic …

kr (code pays fourni par la source)

Comprehensive Classification of Surgically Resected Pituitary Neuroendocrine Tumors: Updates From a Single-Institution Experience Based on the WHO 5th Edition

Hyunhee Kim, Eric Eunshik Kim, Yong Hwy Kim, Jin Woo Park et autres

BACKGROUND: The 5th edition of WHO classification (WHO5) renamed pituitary adenoma as pituitary neuroendocrine tumor (PitNET), aligning with NET nomenclature from other sites. This study investigated the clinicopathological characteristics of surgically resected PitNET based on the WHO5 classification. METHODS: A retrospective analysis …

kr (code pays fourni par la source)

NTRK-fused central nervous system tumours: clinicopathological and genetic insights and response to TRK inhibitors

Eric Eunshik Kim, Seung‐Ki Kim, Ji Hoon Phi, Sun Ha Paek et autres

Background Neurotrophic tropomyosin receptor kinase (NTRK) gene fusions are found in 1% of gliomas across children and adults. TRK inhibitors are promising therapeutic agents for NTRK-fused gliomas because they are tissue agnostic and cross the blood-brain barrier (BBB). Methods We investigated twelve …

kr, pr (code pays fourni par la source)

Primary epithelioid inflammatory myofibroblastic sarcoma of the brain with EML4::ALK fusion mimicking intra-axial glioma: a case report and brief literature review

Eric Eunshik Kim, Chul‐Kee Park, Koung Mi Kang, Yoonjin Kwak et autres

An aggressive subtype of inflammatory myofibroblastic tumor, epithelioid inflammatory myofibroblastic sarcoma occurs primarily inside the abdominal cavity, followed by a pulmonary localization. Most harbor anaplastic lymphoma kinase (ALK) gene rearrangements, with RANBP2 and RRBP1 among the well-documented fusion partners. We report the …

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An Autopsy-proven Case-based Review of Autoimmune Encephalitis

Yumi Shim, Seong‐Ik Kim, So Dug Lim, Kwanghoon Lee et autres

Autoimmune encephalitis (AIE) is a type of immunoreactive encephalitic disorder and is recognized as the most prevalent noninfectious encephalitis. Nevertheless, the rarity of definitive AIE diagnosis through biopsy or autopsy represents a significant hurdle to understanding and managing the disease. In this …

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Methylation-based Subclassifications of Embryonal Tumor with Multilayered Rosettes in Not Just Pediatric Brains

Eric Eunshik Kim, Kwanghoon Lee, Ji-Hoon Phi, Minsung Kim et autres

mutations with germline and second-hit somatic mutations in cancer.

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Genomic profiles of IDH-mutant gliomas: MYCN-amplified IDH-mutant astrocytoma had the worst prognosis

Kwang-Hoon Lee, Seong‐Ik Kim, Eric Eunshik Kim, Yumi Shim et autres

This study aimed to find any ambiguous genetic outlier for "oligodendroglioma, IDH-mutant and 1p/19q-codeleted (O_IDH_mut)" and "astrocytoma, IDH-mutant (A_IDH_mut)" and to redefine the genetic landscape and prognostic factors of IDH-mutant gliomas. Next-generation sequencing (NGS) using a brain tumor-targeted gene panel, methylation profiles, …

kr, pr (code pays fourni par la source)

Epigenetic Alteration of H3K27me3 as a Possible Oncogenic Mechanism of Central Neurocytoma

Hyunhee Kim, Kwang-Hoon Lee, Yumi Shim, Eric Eunshik Kim et autres

Central neurocytoma (CN) is a low-grade neuronal tumor that mainly arises from the lateral ventricle (LV). This tumor remains poorly understood in the sense that no driver gene aberrations have been identified thus far. We investigated immunomarkers in fetal and adult brains …

kr, Éthiopie, pr (code pays fourni par la source)

Genomic profiles of IDH-mutant gliomas: MYCN amplified IDH-mutant astrocytoma had the worst prognosis

Kwang-Hoon Lee, Seong‐Ik Kim, Eric Eunshik Kim, Yumi Shim et autres

Abstract This studyprogression-freene the genetic landscape and prognostic factor of IDH-mutant gliomas. Next-generation sequencing (NGS) using a brain tumor-targeted gene panel, methylation profiles, and clinicopathological features were analyzed for O_IDH_mut (n = 74) in 70 patients and for A_IDH_mut (n = 95) …

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Expanding the Clinicopathologic Spectrum of YAP1::MAML2–Rearranged Thymic Neoplasm

Eric Eunshik Kim, Ye Yoon Suh, Sang‐Won Lee, Jeong Mo Bae et autres

kr, pr (code pays fourni par la source)

Brain Tumor Classification by Methylation Profile

Jin Woo Park, Kwanghoon Lee, Eric Eunshik Kim, Seong‐Ik Kim et autres

The goal of the methylation classifier in brain tumor classification is to accurately classify tumors based on their methylation profiles. Accurate brain tumor diagnosis is the first step for healthcare professionals to predict tumor prognosis and establish personalized treatment plans for patients. …

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