Henning Klapproth

Accumulation of the immunosuppressive metabolite 1-methylnicotinamide in human basal cell carcinoma

Luisa Bopp, Robert Seitz, Manuel Huerta Arana, Sarah Helene Schmidt et autres

de, ca (code pays fourni par la source)

A STAT1/ETC/GBP1 axis represents a potential therapeutic target for noncommunicable granulomatous skin disease

Manuel Huerta Arana, Henning Klapproth, Michal A. Stanczak, Luisa Bopp et autres

Granuloma annulare (GA) and cutaneous sarcoidosis (cSAR) have an overlapping immunopathology, in which the aberrant activation of macrophages by IFN-γ constitutes a central driver. Nevertheless, the molecular understanding in GA and cSAR macrophages remains limited. We reanalyzed single-cell RNA sequencing data of …

de, us, nz, ca (code pays fourni par la source)

Kutane Infektionen mit nicht‐tuberkulösen Mykobakterien: eine retrospektive Studie mit 94 Fällen aus Deutschland

Luisa Bopp, Nicolai Deresz, Henning Klapproth, Isabelle Suárez et autres

Zusammenfassung Hintergrund Kutane nichttuberkulöse Mykobakterien‐Infektionen (NTM) sind diagnostisch und therapeutisch herausfordernd. Ziel dieser Studie war die Charakterisierung kutaner NTM‐Infektionen in Deutschland über einen Zeitraum von 24 Jahren. Patienten und Methodik Eingeschlossen wurden 73 Patienten mit kutanen NTM‐Infektionen, die zwischen 2000 und 2011 …

de (code pays fourni par la source)

Prevalence and management of mental health comorbidities in a German cohort of patients with Ehlers-Danlos syndromes and a generalized hypermobility spectrum disorder

Michaela Henning, Marie Hock, Arim Shukri, Vanessa Löw et autres

OBJECTIVE: The objective of this study was to examine mental health comorbidities and their management in individuals living in Germany with generalized symptomatic hypermobility, including Ehlers-Danlos Syndromes (EDS) and generalized hypermobility spectrum disorder (G-HSD). METHODS: We conducted a descriptive cross-sectional study at …

de (code pays fourni par la source)

Prevalence and management of mental health comorbidities in a German cohort of patients with Ehlers-Danlos syndromes and a generalized hypermobility spectrum disorder

Michaela Henning, Marie Hock, Arim Shukri, Vanessa Löw et autres

Abstract Objective The objective of this study was to examine mental health comorbidities and their management in individuals living in Germany with generalized symptomatic hypermobility, including Ehlers-Danlos Syndromes (EDS) and generalized hypermobility spectrum disorder (G-HSD). Methods We conducted a descriptive cross-sectional study …

de (code pays fourni par la source)

Additional file 1 of Prevalence and management of mental health comorbidities in a German cohort of patients with Ehlers-Danlos syndromes and a generalized hypermobility spectrum disorder

Michaela Henning, Marie Hock, Arim Shukri, Vanessa Löw et autres

Supplementary Material 1

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Additional file 1 of Prevalence and management of mental health comorbidities in a German cohort of patients with Ehlers-Danlos syndromes and a generalized hypermobility spectrum disorder

Michaela Henning, Marie Hock, Arim Shukri, Vanessa Löw et autres

Supplementary Material 1

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Prevalence and management of mental health comorbidities in a German cohort of patients with Ehlers-Danlos syndromes and a generalized hypermobility spectrum disorder

Michaela Henning, Marie Hock, Arim Shukri, Vanessa Löw et autres

Abstract Objective The objective of this study was to examine mental health comorbidities and their management in individuals living in Germany with generalized symptomatic hypermobility, including Ehlers-Danlos Syndromes (EDS) and generalized hypermobility spectrum disorder (G-HSD). Methods We conducted a descriptive cross-sectional study …

de (code pays fourni par la source)

Cutaneous non‐tuberculous mycobacterial infections: A retrospective study of 94 cases from Germany

Luisa Bopp, Nicolai Deresz, Henning Klapproth, Isabelle Suárez et autres

BACKGROUND: Cutaneous non-tuberculous mycobacterial infections (NTM) remain a diagnostic and therapeutic challenge. The aim of this study was to characterize cutaneous NTM infections in Germany over a 24-year-period. PATIENTS AND METHODS: 73 patients with cutaneous NTM infections diagnosed at 17 different German …

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Metformin in necrobiotic xanthogranuloma

Henning Klapproth, Manuel Huerta Arana, Jan‐Wilm Lackmann, Luisa Bopp et autres

Necrobiotic xanthogranuloma (NXG) represents a rare granulomatous skin disease characterized by IFN-γ-activated macrophages with limited treatment options. This study shows that metformin not only suppresses IFN-γ-induced macrophage activation, but also induced clinical remission in a patient with NXG. These findings highlight metformin …

de, ca (code pays fourni par la source)

Health care supply in patients with Ehlers-Danlos syndromes and generalized hypermobility spectrum disorder: a German perspective

Jonas Rauterberg, Marie Hock, Nikolaus Kernich, Arim Shukri et autres

BACKGROUND: Diagnosing Ehlers-Danlos syndromes (EDS) and EDS-related "hypermobility spectrum disorder" (HSD) is challenging and cutaneous manifestations often serve as indicators of these rare connective tissue disorders. Only limited data exist on the healthcare of EDS/HSD in Germany as specialized services have been …

de (code pays fourni par la source)

Humanised Mice in Cutaneous Leishmaniasis—T‐Cell Recruitment Into Human Skin Transplants After Leishmania major Infection

Miao Ling, Henning Klapproth, Michael R. Stepkes, Joanna Wegner et autres

ABSTRACT Treatment against leishmaniasis is associated with severe side effects, high costs, and parasitic resistance. Preclinical models such as humanised mice would aid therapeutic improvement or the development of a vaccine. We developed a model in which human skin transplants on immunodeficient …

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