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Mark Ng, Emily Zygiel, Jinsheng Liang, Luhua Shen et autres
Background: The tumor suppressor protein p53 (TP53) plays a pivotal role in preventing tumor formation by inducing cell cycle arrest and apoptosis in response to DNA damage. However, TP53 mutations are prevalent across various cancer types, and these mutations not only result …
Mark Ng, Emily Zygiel, Jinsheng Liang, Luhua Shen et autres
Background The tumor suppressor protein p53 (TP53) plays a pivotal role in preventing tumor formation by inducing cell cycle arrest and apoptosis in response to DNA damage. However, TP53 mutations are prevalent across various cancer types, and these mutations not only result …
Xiaoyang Zhang, Peter S. Choi, Joshua M. Francis, Galen F. Gao et autres
Table S2: Oligos used in the study
Xiaoyang Zhang, Peter S. Choi, Joshua M. Francis, Galen F. Gao et autres
Figure S1. Super-enhancers near the KLF5 gene are focally amplified in cancer cell lines;Figure S2. The regulatory potential of the KLF5/KLF12 intervening region;Figure S3. Expression level of KLF12, DIS3 and PIBF1 after repression of KLF5 superenhancers;Figure S4. Genomic analysis of KLF5 binding …
Xiaoyang Zhang, Peter S. Choi, Joshua M. Francis, Galen F. Gao et autres
Abstract The Krüppel-like family of transcription factors plays critical roles in human development and is associated with cancer pathogenesis. Krüppel-like factor 5 gene (KLF5) has been shown to promote cancer cell proliferation and tumorigenesis and to be genomically amplified in cancer cells. …
Xiaoyang Zhang, Peter S. Choi, Joshua M. Francis, Galen F. Gao et autres
Table S1: KLF5 E419Q-gained super-enhancers and the nearest genes
Xiaoyang Zhang, Peter S. Choi, Joshua M. Francis, Galen F. Gao et autres
Table S1: KLF5 E419Q-gained super-enhancers and the nearest genes
Xiaoyang Zhang, Peter S. Choi, Joshua M. Francis, Galen F. Gao et autres
Figure S1. Super-enhancers near the KLF5 gene are focally amplified in cancer cell lines;Figure S2. The regulatory potential of the KLF5/KLF12 intervening region;Figure S3. Expression level of KLF12, DIS3 and PIBF1 after repression of KLF5 superenhancers;Figure S4. Genomic analysis of KLF5 binding …
Xiaoyang Zhang, Peter S. Choi, Joshua M. Francis, Galen F. Gao et autres
Table S2: Oligos used in the study
Xiaoyang Zhang, Peter S. Choi, Joshua M. Francis, Galen F. Gao et autres
Abstract The Krüppel-like family of transcription factors plays critical roles in human development and is associated with cancer pathogenesis. Krüppel-like factor 5 gene (KLF5) has been shown to promote cancer cell proliferation and tumorigenesis and to be genomically amplified in cancer cells. …
Wenchu Lin, Hideo Watanabe, Shouyong Peng, Joshua M. Francis et autres
Table S2. H3K4me3 Peaks in Men1 KO islets
Wenchu Lin, Hideo Watanabe, Shouyong Peng, Joshua M. Francis et autres
Supplementary Fig. S3. Histone mark profiles in Hox genes
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