Artitaya Lophatananon

Environmental Pollution, Biomarkers, and Dementia: An Evidence Review

Yicong; id_orcid 0009-0001-1705-7789 Huang, C.S. Park, Artitaya Lophatananon, Kenneth R. Muir

With rapid global urbanization, exposure to environmental pollutants has emerged as a potentially important determinant of cognitive health. We therefore systematically searched PubMed and Embase for epidemiological studies published between 2020 and 2026 and reviewed the associations between ambient air pollution, environmental …

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Causal roles of phenotypic age acceleration and metabolic health on dementia: a Mendelian randomisation and structure learning study

Alexandra Baousi, Katrina Dobinda, Jingqi Zhu, Xinzhu Yu et autres

Summary Background Phenotypic age acceleration (PhenoAgeAccel), derived from PhenoAge, and MetaboHealth are composite exposures of biological ageing and metabolic health associated with dementia-related outcomes. Whether these associations are causal and reflect the exposures, constituent biomarkers, or both remains unclear. Methods This study …

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Metabolic Dysfunction and Related Dietary Exposures in Relation to Pancreatic Cancer Risk: A Review of the Evidence

Junsu Yang, Yicong; id_orcid 0009-0001-1705-7789 Huang, Artitaya Lophatananon, Kenneth; id_orcid 0000-0001-6429-988X Muir

Pancreatic cancer is a highly lethal malignancy with an increasing global incidence. Although metabolic dysfunction has been implicated in pancreatic cancer risk, the strength and consistency of evidence across different metabolic traits remain uncertain. Evidence for dietary exposures related to metabolic regulation …

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Epigenetic mechanisms linking hexavalent chromium exposure to pancreatic cancer risk: a systematic review

Kai Hayashi, Yicong Huang, Kenneth R Muir, Artitaya Lophatananon

Abstract Pancreatic cancer remains one of the most lethal malignancies, largely due to late diagnosis and limited treatment options. Hexavalent chromium (Cr(VI)) is a well-established environmental and occupational carcinogen, and emerging epidemiological observations have raised questions about its potential involvement in cancers …

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Threshold-Based Overlap of Breast Cancer High-Risk Classification Using Family History, Polygenic Risk Scores, and Traditional Risk Models in 180,398 Women

Peh Joo Ho, Christine Kim Yan Loo, Mui Heng Goh, Mustapha Abubakar et autres

Background: Breast cancer polygenic risk scores (PRS) and traditional risk models (e.g., the Gail model [Gail]) are known to contribute largely independent information, but it is unclear how the overlap varies by ancestry, age, disease type (invasive breast cancer, DCIS), and risk …

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Risk of Esophageal and Gastric Cancer by Histologic Subtype in Steatotic Liver Disease: A UK Biobank Study

Dong Hoon Kang, Ji Won Han, Kenneth Muir, Artitaya Lophatananon et autres

AIM: The recently updated steatotic liver disease (SLD) nomenclature provides a refined classification accounting for both metabolic dysfunction and alcohol exposure. However, the relationship between SLD subtypes and upper gastrointestinal (UGI) cancer risk remains unclear. METHODS: We analyzed 456,367 UK Biobank participants, …

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Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification

Maria Zanti, Denise G O'Mahony, Michael T. Parsons, Leila Dorling et autres

Clinical genetic testing identifies variants causal for hereditary cancer, information that is used for risk assessment and clinical management. Unfortunately, some variants identified are of uncertain clinical significance (VUS), complicating patient management. Case-control data is one evidence type used to classify VUS. …

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Investigating causal networks of dementia using causal discovery and natural language processing models

Xinzhu Yu, Artitaya Lophatananon, Kenneth Muir, Hui Guo

Comprehensively studying modifiable risk factors to understand their contributions to dementia mechanisms is imperative. This study used natural language processing (NLP) models to pre-select candidate risk factors for dementia from 5505 baseline variables in the UK Biobank. We then applied causal discovery …

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Overlap of high-risk individuals across family history, genetic & non-genetic breast cancer risk models: Analysis of 180,398 women from European & Asian ancestries

Peh Joo Ho, Christine Kim Yan Loo, Mui Heng Goh, Mustapha Abubakar et autres

ABSTRACT Background Breast cancer is multifactorial. Focusing on limited risk factors may miss high-risk individuals. Methods We assessed the performance and overlap of various risk factors in identifying high-risk individuals for invasive breast cancer (BrCa) and ductal carcinoma in situ (DCIS) in …

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The 5‐year results of the Stratified Cancer Active Surveillance programme for men with prostate cancer

Vincent J. Gnanapragasam, Alexandra Keates, Artitaya Lophatananon, Vineetha Thankapannair

OBJECTIVES: To report 5-year outcomes from the STRATified CANcer Surveillance (STRATCANS) programme based on progression risks using National Institute for Health and Clinical Excellence (NICE) Cambridge Prognostic Group (CPG) at diagnosis, prostate specific antigen density and magnetic resonance imaging (MRI) visibility. PATIENTS …

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Overlap of High-Risk Individuals Predicted by Family History, Genetic and Non-Genetic Breast Cancer Risk Prediction Models: An Analysis of 180,398 Women Across European and Asian Ancestry Populations

Peh Joo Ho, Christine Kim Yan Loo, Mui Heng Goh, Mustapha Abubakar et autres

A PSA SNP associates with cellular function and clinical outcome in men with prostate cancer

Srilakshmi Srinivasan, Thomas Kryza, Nathalie Bock, Brian Wan-Chi Tse et autres

Genetic variation at the 19q13.3 KLK locus is linked with prostate cancer susceptibility in men. The non-synonymous KLK3 single nucleotide polymorphism (SNP), rs17632542 (c.536 T > C; Ile163Thr-substitution in PSA) is associated with reduced prostate cancer risk, however, the functional relevance is …

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