Zhonghan Lou

Linking Hyperuricemia to Cancer: Emerging Evidence on Risk and Progression

Lingyun Zhao, Ruihong Guo, Ziming Zhao, Jue Wang et autres

mo, us, cn, se, au, hk (code pays fourni par la source)

An Integration of RNA Sequencing and Network Pharmacology Approaches Predicts the Molecular Mechanisms of the Huo-Xue-Shen Formula in the Treatment of Liver Fibrosis

Keying Jiang, Jianfeng Bao, Zhonghan Lou, Fei Liu et autres

Background: Liver fibrosis is a prevalent, chronic inflammatory condition characterized by the excessive accumulation of extracellular matrix components and, primarily, collagen in the liver. Huo-xue-shen (HXS) has proven effective for the treatment of liver fibrosis. However, the mechanism is yet to be …

hk, cn, mo (code pays fourni par la source)

Elevated extracellular matrix protein 1 in circulating extracellular vesicles supports breast cancer progression under obesity conditions

Keyang Xu, Ai Fu, Zhaoyi Li, Liangbin Miao et autres

The cargo content in small extracellular vesicles (sEVs) changes under pathological conditions. Our data shows that in obesity, extracellular matrix protein 1 (ECM1) protein levels are significantly increased in circulating sEVs, which is dependent on integrin-β2. Knockdown of integrin-β2 does not affect …

hk, cn (code pays fourni par la source)

Serum CHI3L1 as a Biomarker for Non-invasive Diagnosis of Liver Fibrosis.

Jianfeng Bao, Yuan Ouyang, Liang Qiao, Jiahui He et autres

BACKGROUND: Liver fibrosis is the early pathological manifestation of various chronic liver diseases (including schistosomiasis, alcoholic, viral, nonalcoholic, fatty liver, etc.), which can progress to cirrhosis and even liver cancer. Out of the 7.7 billion world population, approximately 2 billion individuals have …

cn, au (code pays fourni par la source)