Tohru Nagahama

A novel biomimetic hair colouring system based on the eumelanin precursor 5,6‐dihydroxyindole

Yuji Mochizuki, 杏奈 井出, Akiyori Fujiwara, Tohru Nagahama et autres

OBJECTIVE: The use of traditional hair dyeing agents to dye hair may cause scalp and hair damage, induce melanocyte stem cell depletion, and in some cases trigger allergic reactions. Therefore, we explored a novel hair colouring approach using 5,6-dihydroxyindole (DHI), a precursor …

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Dermal Formulation Incorporating Isoconazole Nitrate Nanoparticles Offers High Absorption into Skin and Antimicrobial Effect Against Candida albicans

Ayako Harada, Rie Tanaka, Hiroko Otake, Masanori Yoshimura et autres

Background: Isoconazole nitrate (ISN), an antifungal agent that inhibits ergosterol synthesis by blocking lanosterol 14α-demethylation, is widely used to treat candidiasis, and improving its skin retention and permeability can enhance its therapeutic efficacy. Therefore, we developed an ISN nanoparticle (ISN-NP) gel by …

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Taurine accelerates the synthesis of ceramides and hyaluronic acid in cultured epidermis and dermal fibroblasts

Tomohisa Yoshimura, Chika Manabe, Jun-Ichiro Nagumo, Tohru Nagahama et autres

Taurine is a sulfur-containing amino acid derivative that can be found in the majority of mammalian tissues. Taurine is also present in the skin and is involved in maintaining skin homeostasis by exerting osmoregulatory and antioxidant effects. Previous studies have indicated that …

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A trial to predict skin irritancy of cosmetic products using cytotoxicity tests

Minori Mezaki, Chika Manabe, Jun-Ichiro Nagumo, Tomohisa Yoshimura et autres

Alternatives to animal testing are being used to assess the safety of raw ingredients during the process of developing cosmetics. However, since cosmetic products are composed of a variety of raw ingredients, the safety of the product itself should also be tested. …

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Effects of Skin Environmental Changes by Steam Towel, Ethanol, l-Menthol and Carpronium on the Drug Behavior in the Minoxidil Nanoparticles-applied Mice

Ryoka Goto, Yoshihiro Oaku, Fuka Sasaki, Chika Kubota et autres

We previously designed the formulation containing minoxidil (MXD) nanoparticles (MXD-NPs), and found that the MXD-NPs can mainly deliver MXD into hair bulbs via hair follicles pathway, and that the therapeutic efficiency for hair growth is higher in comparison with the formulation containing …

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Development of Artificial-Sebum-Containing Leeming and Notman Agar Medium to Enhance the Growth of Malassezia

Kazuhiro Suzuki, Mizuna Inoue, Kodai Takayama, Tohru Nagahama et autres

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Minoxidil Nanoparticles Targeting Hair Follicles Enhance Hair Growth in C57BL/6 Mice

Yoshihiro Oaku, Akinari Abe, Yohei Sasano, Fuka Sasaki et autres

We previously found that 1% minoxidil (MXD) nanoparticles prepared using a bead mill method led to an increase I n hair follicle delivery and hair growth in C57BL/6 mice. In the present study, we designed a nanoparticle formulation containing 5% MXD (MXD-NPs) …

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Short sequence repeats of the intergenic spacer regions of ribosomal RNA genes in Malassezia globosa and Malassezia restricta colonizing the scalps of male individuals with and without androgenetic alopecia

Kazuhiro Suzuki, Otomi Cho, Tohru Nagahama, Takashi Sugita

Abstract We analyzed the short sequence repeats (SSRs) of the intergenic spacer (IGS) region 1 of the ribosomal RNA genes in Malassezia globosa and Malassezia restricta, which predominantly colonize the scalp in androgenetic alopecia (AGA). No AGA‐specific SSRs were found in the …

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Development of Artificial Sebum-containing Leeming and Notman Agar Medium to Enhance the Growth of Malassezia

Kazuhiro Suzuki, Mizuna Inoue, Kodai Takayama, Tohru Nagahama et autres

Abstract Modified Leeming and Notman agar medium (mLNA) has been widely utilized to grow lipophilic fungi belonging to the genus Malassezia. We developed a new artificial sebum-containing mLNA to obtain higher yields of Malassezia spp. The olive oil in mLNA was replaced …

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Development of scales to measure the impression of persons and fragrances

Yukiko Takata, Fuminari Akiyama, Nobuyuki Takeuchi, Tohru Nagahama et autres

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Scalp Microbiome and Sebum Composition in Japanese Male Individuals with and without Androgenetic Alopecia

Kazuhiro Suzuki, Mizuna Inoue, Otomi Cho, Rumiko Mizutani et autres

The skin microbiome and sebum may be associated with inflammation-related diseases of the scalp. To assess the pathogenesis and progression of androgenetic alopecia (AGA), we analyzed the composition of sebum and the bacterial and fungal microbiomes of the scalps of 118 Japanese …

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Protective effect of taurine on UVB-induced skin aging in hairless mice

Tomohisa Yoshimura, Chika Manabe, Yuki Inokuchi, Chikako Mutou et autres

Taurine, a sulfur-containing amino acid derivative, exists at a high concentration in the skin and is considered to play an important role in maintaining moisture homeostasis. This study investigated the effects of oral taurine supplementation on epidermal moisture content and wrinkle formation, …

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