Eivind Witsø

Biofilm and the effect of sonication in a chronic Staphylococcus epidermidis orthopedic in vivo implant infection model

Erik Thorvaldsen Sandbakken, Erling Høyer, Eivind Witsø, Caroline Krogh Søgaard et autres

BACKGROUND: In diagnosing chronic orthopedic implant infections culture of sonicate represents a supplement to tissue cultures. However, the extent to which biofilm forms on implant surfaces and the degree of dislodgement of bacteria by sonication remains unclear. In this in vivo study …

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Novel Peptides Targeting the β-Clamp Rapidly Kill Planktonic and Biofilm Staphylococcus epidermidis Both in vitro and in vivo

Synnøve Brandt Ræder, Erik Thorvaldsen Sandbakken, Anala Nepal, Kirsti Løseth et autres

Antimicrobial resistance is an increasing threat to global health and challenges the way we treat infections. Peptides containing the PCNA interacting motif APIM (APIM-peptides) were recently shown to bind to the bacterial PCNA homolog, the beta (β)-clamp, and to have both antibacterial …

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Highly variable effect of sonication to dislodge biofilm-embedded Staphylococcus epidermidis directly quantified by epifluorescence microscopy: an in vitro model study

Erik Thorvaldsen Sandbakken, Eivind Witsø, Bjørnar Sporsheim, Kjartan Wollo Egeberg et autres

BACKGROUND: In cases of prosthetic joint infections, culture of sonication fluid can supplement culture of harvested tissue samples for correct microbial diagnosis. However, discrepant results regarding the increased sensitivity of sonication have been reported in several studies. To what degree bacteria embedded …

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Transmission of infection from non-isolated patients with COVID-19 to healthcare workers

Trude Basso, Svein Arne Nordbø, Emilie Sundqvist, Tom Christian Martinsen et autres

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Virus transmission during orthopedic surgery on patients with COVID-19 – a brief narrative review

Trude Basso, Håvard Dale, Håkon Langvatn, Greger Lønne et autres

Background and purpose - COVID-19 is among the most impactful pandemics that the society has experienced. Orthopedic surgery involves procedures generating droplets and aerosols and there is concern amongst surgeons that otherwise rational precautionary principles are being set aside due to lack …

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Rifampin Combination Therapy in Staphylococcal Prosthetic Joint Infections: A Randomized Controlled Trial

Øystein Espeland Karlsen, Pål Oliver Borgen, Bjørn Bragnes, Wender Figved et autres

Abstract Background The evidence supporting rifampin combination therapy in prosthetic joint infections (PJI) is limited due to the lack of controlled studies. The aim of this study is to evaluate the effect of adding rifampin to conventional antimicrobial therapy in early staphylococcal …

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Establishment of an in vivo rat model for chronic musculoskeletal implant infection

Eivind Witsø, Linh Hoang, Kirsti Løseth, Kåre Bergh

BACKGROUND: The aim of the study was to establish an experimental chronic musculoskeletal infection model in vivo characterized by (a) a small bacterial inoculum, (b) no general or local signs of infection, (c) several parallels (implants) in each animal and finally (d) …

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2018 international consensus meeting on musculoskeletal infection: Summary from the biofilm workgroup and consensus on biofilm related musculoskeletal infections

Kordo Saeed, Alex C. McLaren, Edward M. Schwarz, Valentin Antoci et autres

Biofilm-associated implant-related bone and joint infections are clinically important due to the extensive morbidity, cost of care and socioeconomic burden that they cause. Research in the field of biofilms has expanded in the past two decades, however, there is still an immense …

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Hip and Knee Section, What is the Definition of a Periprosthetic Joint Infection (PJI) of the Knee and the Hip? Can the Same Criteria be Used for Both Joints?: Proceedings of International Consensus on Orthopedic Infections

Noam Shohat, Thomas W. Bauer, Martin Alejandro Buttaro, Nicolaas Cyrillus Budhiparama et autres

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General Assembly, Prevention, Local Antimicrobials: Proceedings of International Consensus on Orthopedic Infections

José Baeza, Marco Bernardo Cury Fernandes, Andrew N. Fleischman, Albert Ferrando et autres

MONITORING THE INCIDENCE OF PROSTHETIC JOINT INFECTIONS IN A COMPLICATION REGISTRY

Tina S Wik, Olav Andreas Foss, Jomar Klaksvik, Siri Bjørgen Winther et autres

Aim The incidence of prosthetic joint infections can be severe to monitor, as they are rare events. Recent publications from National registries points toward a significant underestimation of reported infections. The aim of this project was to develop a complication register that …

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Editorial

Eivind Witsø

During the last couple of years several articles on prosthetic joint infection (PJI) have been published in Acta Orthopaedica, ranging for example from papers on experimental studies, new surgical ...

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