Richard J.E. Skipworth

Non-Inferiority Margins in Randomized Controlled Trials in Abdominal Surgery – a Systematic Review

Carl Leonhardt, Dominique Birrer, Max F. Stauffer, Johannes Maria Alberto Toti et autres

ABSTRACT Importance Non-inferiority trials are becoming increasingly popular in abdominal surgery. The non-inferiority margin is critical in the interpretation and conclusion of these trials. Objective This systematic review aims to assess the methodological and reporting quality of non-inferiority randomized controlled trials in …

de, se, at, ch, gb (code pays fourni par la source)

Cachexia and Wasting in Chronic Illness: Regulatory and Clinical Trial Update

Francesco Fioretti, Stephan von Haehling, Andrew J.S. Coats, Javed Butler et autres

Cachexia, a syndrome marked by nonintentional weight loss, muscle wasting, functional decline and poor prognosis, affects 50%-80% of cancer patients, severely impacting quality of life, treatment tolerance and survival. A 'Regulatory and Trial Update Workshop' was organized by the Society on Cachexia …

it, de, au, gb, us (code pays fourni par la source)

Impact of environmental factors on operative team performance: systematic review and guidance for optimising clinical practice

Connor Boyle, James Crichton, A Sgrò, Sarah H. Michael et autres

OBJECTIVE: To evaluate the range and impact of environmental factors on the operative performance of surgical teams. BACKGROUND: Optimising surgical performance is critical for patient safety and clinical efficiency. Recent efforts have focussed on both individual (e.g. stress-management, situation awareness) and team …

gb, us (code pays fourni par la source)

Correction: A role of arginase-1-expressing myeloid cells in cachexia

Apsana Lamsal, Sonja Andersen, Unni Nonstad, Natalie J. Kurganovs et autres

no, gb (code pays fourni par la source)

General Principles in Surgery

Tania Triantafyllou, Richard J.E. Skipworth

This chapter will consider the entire patient journey from preoperative decision-making to postoperative functional recovery. It takes into consideration the recently established principles of prehabilitation and Enhanced Recovery After Surgery (ERAS). Non-Operative Technical Skills for Surgeons (NOTSS) are discussed in Chapter 1.8 …

‘Play to the conditions’: optimizing the operating theatre environment through lessons from elite performance domains

Connor Boyle, James Crichton, A Sgrò, Sarah H. Michael et autres

In 2014, a judicial court in Brazil was an unusual setting for a defining moment in the relationship between elite sport and the physical environment1. In response to athlete demands, the court required water breaks in football World Cup games when the …

gb, us (code pays fourni par la source)

New insights into total and resting energy expenditure using state-of-the-art methods in cancer survivors: a cross-sectional study

Ana Paula Pagano, João Felipe Mota, Sarah A. Purcell, Iasmin Matias de Sousa et autres

BACKGROUND: Precise measurement of energy expenditure is essential for guiding nutritional care after cancer treatment. However, commonly used predictive equations may be inaccurate for individuals recovering from cancer. Leveraging state-of-the-art methods can offer valuable insights into the actual energy requirements of cancer …

ca, br, us, gb, il (code pays fourni par la source)

Impact of staging investigations on nodal upstaging in early esophago-gastric adenocarcinoma: multicenter CONGRESS dataset analysis

Kirsty Cole, James Gossage, Pradeep Bhandari, Natalie Blencowe et autres

Current recommendations for the clinical staging of patients undergoing resection for early esophago-gastric (OG) cancer are variable and the value of staging investigations is unclear. The aim of this study was to assess current practice for staging early OG cancers across the …

gb, au (code pays fourni par la source)

Postoperative outcomes after minimally invasive esophagectomy: an international cohort study from the Oesophagogastric Anastomosis Audit (OGAA)

Derek Alderson, James Bundred, Richard Evans, James Gossage et autres

Abstract Objective To compare the postoperative pulmonary complications (PPC) after minimally invasive or open transthoracic esophagectomy for esophageal cancer in an international, multicenter cohort. Summary of background data Ongoing debate exists around the optimal surgical approach for esophageal cancer, with limited data …

gb (code pays fourni par la source)

138 A Comparison of Established Diagnostic Criteria for Cachexia and Their Impact on Prognostication in Patients with Oesophagogastric Cancer

Leo R. Brown, Maria Soupashi, Michael S. Yule, Cathleen Grossart et autres

Abstract Background Cachexia is common in oesophagogastric cancer, yet heterogeneity in its definition has hindered clinical utilisation. This study compared the two established cachexia definitions (Fearon’s consensus definition and the Global Leadership Initiative on Malnutrition [GLIM] criteria) and their relationship with survival …

gb (code pays fourni par la source)

Context-dependent effects of CDKN2A and other 9p21 gene losses during the evolution of esophageal cancer

Piyali Ganguli, Celia De Los Angeles Colomina Basanta, Amelia Acha‐Sagredo, Hrvoje Mišetić et autres

CDKN2A is a tumor suppressor located in chromosome 9p21 and frequently lost in Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). How CDKN2A and other 9p21 gene co-deletions affect EAC evolution remains understudied. We explored the effects of 9p21 loss in EACs and …

gb, se (code pays fourni par la source)

Comparison Between Single‐ and Multi‐slice Computed Tomography Body Composition Analysis in Patients With Oesophagogastric Cancer

Leo R. Brown, Maria Soupashi, Michael S. Yule, Danielle Clyde et autres

BACKGROUND: Single-slice computed tomography (CT) body composition has been studied extensively for prognostication in patients with cancer. New software packages can also provide multi-slice volumetric measurements, but the clinical utility of these remains under explored. This study aimed to evaluate the agreement …

gb (code pays fourni par la source)