Qinjuan Wu

Perioperative immune dynamics during cardiopulmonary bypass and association with major adverse postoperative events

Zhiyuan Cheng, Xinyi Liao, Juan Wu, Ping Yang et autres

Purpose To clarify how cardiopulmonary bypass (CPB) affects perioperative immune cell populations and how these changes are associated with postoperative organ dysfunction. Methods We prospectively recruited 60 consecutive patients who underwent CPB as part of elective valvular surgery and/or coronary artery bypass …

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Perioperative Profiles of Immune Cells in Patients with Postoperative Delirium After Cardiac Surgery with Cardiopulmonary Bypass

Juan Wu, Zhenzhen Cheng, Xinyi Liao, Qinjuan Wu et autres

Background: Postoperative delirium (POD) is known to involve systemic inflammatory responses, but the characteristics of the immune cell types involved in these responses are unclear. Methods: In this prospective study, we compared relative abundances and transcriptomes of circulating immune cells between patients …

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Single-cell immune landscape of acute kidney injury after cardiac surgery with cardiopulmonary bypass

Tingting Wang, Yuanyuan Yao, Jiayi Sun, Juan Wu et autres

Objectives Acute kidney injury (AKI) occurs in 19–42% of patients with cardiac surgery under cardiopulmonary bypass (CPB). Clarifying their landscape of immune cells may help discover the mechanisms and thus the treatment and preventive strategies.Methods This prospective, single center study recruited adult …

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Integrated analysis of histone lysine lactylation (Kla)-specific genes suggests that NR6A1, OSBP2 and UNC119B are novel therapeutic targets for hepatocellular carcinoma

Qinjuan Wu, Xin Li, Menghong Long, Xianfeng Xie et autres

(FlodChange (FC))| > 2, p-value < 0.05, following investigating the prognostic value. The correlation between lactate accumulation and prognostic DEKlaGs expression was further investigated. On the other hand, we explored the roles of Kla activation in the immune microenvironment, immunotherapy, and drug …

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Synthesis of sevoflurane loaded reduced graphene oxide nanoparticles system for neuroprotective effects for preconditioning against focal cerebral ischaemia

Qinjuan Wu, Kun Zhang

In this study, sevoflurane (SF) loaded, Fas ligand conjugated reduced graphene oxide (rGO) system is fabricated as a therapeutic agent to target brain ischaemic region. The fluorescence investigation of mice brain denoted that the encapsulated SF in rGOs adsorbed with Fas ligand …

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[Systematic review of transfusion strategies for cardiac surgery].

Qinjuan Wu, Ronghua Zhou, Bin Liu

This paper is aimed to assess the effects of red blood cell (RBC) transfusion on clinical outcomes in cardiac surgery. Trials were identified by computer searches of the Pubmed, MEDLINE, Cochrane Library (Issue 10, 2012), from January 1980 to October 2012. References …