Hiroshi Hashimoto

Proposal of a Pedestrian Recognition Method for Mobile Robots Using Drones Flying Overhead and a Pedestrian Avoidance Navigation Method Based on It

Masafumi Yoneoka, Lin Ye, Daisuke Chugo, Satoshi Muramatsu et autres

In crowded urban environments, service robots need to guide pedestrians safely while avoiding them. Traditional approaches such as artificial potential field methods enable real-time path planning at low computational cost, but they assume full visibility of pedestrians using on-board sensors such as …

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Identification of a PCNA-binding motif in human translesion DNA polymerase REV1 and structural basis of its interaction with PCNA

Asami Hishiki, Kokona Okawara, Sotaro Fuchigami, Kodai Hara et autres

REV1 is a eukaryotic error-prone DNA polymerase belonging to the Y-family, with a central role in translesion DNA synthesis (TLS) to continue DNA replication even in the presence of DNA damage in the template strand. TLS is stimulated by monoubiquitination of proliferating …

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Optimization of a Model for Predicting Renal Function After Living Kidney Transplantation Using Computed Tomography Volumetry

Yasufumi Kijima, Toshikazu Hirai, Kazuhiro Iwadoh, Y Nishimura et autres

Purpose: Post-transplant kidney function varies among cases, and incorporating more patient-specific data could enhance prediction accuracy. In this study, we investigated whether the prediction accuracy of post-transplant kidney function could be improved by incorporating computed tomography volumetry (CTv) data of the excised …

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Efficacy and Prognostic Factors of Surgical Resection for Pulmonary Metastases From Ovarian Cancer

Yo Tsukamoto, Takashi Ohtsuka, Yoshikane Yamauchi, Mingyon Mun et autres

Background/Aim: Pulmonary metastases (PMs) from ovarian cancer are rare, and the efficacy of surgical intervention is unclear. This study aimed to validate the efficacy of surgical intervention for pulmonary metastases from ovarian cancer. Patients and Methods: Cases were taken from the database …

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3,5-Dihydroxybenzoic Acid as a Potent Inhibitor of Tyrosine Phenol-Lyase Decreases Fecal Phenol Levels in Mice

Takuma Kobayashi, S. Oishi, Kodai Hara, Misaki Matsui et autres

Phenol is produced by β-elimination of l -tyrosine (Tyr) catalyzed by tyrosine phenol-lyase (TPL) during intestinal bacterial metabolism. Phenol and its conjugate, phenyl sulfate (PhS), are protein-bound uremic toxins (PBUTs). Elevated levels of phenol and PhS are strongly implicated in the etiology …

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Estimation of the Position of Loaded Packages in a Roll Cage Cart: Estimating the Placement Layout of Multiple Packages in a Flat Space

Takaya Kako, Sho Yokota, Daisuke Chugo, Satoshi Muramatsu et autres

The purpose of this research is to develop a system that shows the loading position of deliveries in a roll cage cart. This study solves the problem of the difficulty of locating individual deliveries in piles. In the proposed system, it is …

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Path Planning Method for Mobile Robots in Pedestrian-Friendly Environments Using Drone Bird’s-Eye View

Lin Ye, Daisuke Chugo, Satoshi Muramatsu, Sho Yokota et autres

The objective of this paper is to develop a robot system that can transmit the video taken by the drone to the computer in real time, use YOLO to recognize the image of pedestrians, and enable the ground robot to plan the …

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Efficacy and Prognostic Factors of Surgical Resection for Pulmonary Metastases from Ovarian Cancer

Yo Tsukamoto, Takashi Ohtsuka, Yoshikane Yamauchi, Mingyon Mun et autres

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Survival after Lung Metastasectomy from Urothelial Carcinoma: A Multi-Institutional Database Study

Yoshikane Yamauchi, Masaaki Sato, Takekazu Iwata, Makoto Endo et autres

BACKGROUND/OBJECTIVES: The efficacy of lung metastasectomy in patients with urothelial carcinoma remains inconclusive, as there is only limited evidence from small studies. In this study, we aimed to assess the prognostic outcomes of excising pulmonary metastases from urothelial carcinoma. METHODS: In this …

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Effect of luminance of head-up displays on recognition of visual objects on roads

Takashi Hosokawa, Hiroshi Hashimoto, Takayuki Tsui, Keisuke Saito et autres

Objective: The purpose of this study is to investigate the effect of visual obstruction when a head-up display (HUD) is presented in front of a driver's field of view. Background: The use of HUDs is expected to increase due to advances in …

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Tyrosine phenol-lyase inhibitor quercetin reduces fecal phenol levels in mice

Takuma Kobayashi, S. Oishi, Misaki Matsui, Kodai Hara et autres

Abstract Tyrosine phenol-lyase (TPL), which is expressed in intestinal bacteria, catalyzes the formation of phenol from the substrate L-Tyr. Bacterial metabolite phenol and the sulfate conjugate (phenyl sulfate) are known as a type of uremic toxins, some of which exert cytotoxicity. Therefore, …

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Structural and Functional Analyses of Inhibition of Human Dihydroorotate Dehydrogenase by Antiviral Furocoumavirin

Miku Nakahara, Shogo Watanabe, Michio Sato, Hideo Okumura et autres

Natural products are important sources of seed compounds for drug discovery. However, it has become difficult in recent years to discover new compounds with valuable pharmacological activities. On the other hand, among the vast number of natural products that have been isolated …

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