Accès ouvert
2021
article
OpenAlex
Alexander Hirschhäuser, Marianne van Cann, Sven Bogdan
The WAVE regulatory complex (WRC) is the main activator of the Arp2/3 complex, promoting lamellipodial protrusions in migrating cells. The WRC is basally inactive but can be activated by Rac1 and phospholipids, and through phosphorylation. However, the in vivo relevance of the …
de, cz
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Accès ouvert
2021
article
OpenAlex
Jörg Isensee, Marianne van Cann, Patrick Despang, Dionéia Araldi et autres
Depolarization drives neuronal plasticity. However, whether depolarization drives sensitization of peripheral nociceptive neurons remains elusive. By high-content screening (HCS) microscopy, we revealed that depolarization of cultured sensory neurons rapidly activates protein kinase A type II (PKA-II) in nociceptors by calcium influx through …
de, us
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2020
article
OpenAlex
Marianne van Cann, Alexey I. Kuzmenkov, Jörg Isensee, Alexander A. Andreev-Andrievskiy et autres
Venoms are a rich source of highly specific toxins, which allow the identification of novel therapeutic targets. We have now applied high content screening (HCS) microscopy to identify toxins that modulate pain sensitization signaling in primary sensory neurons of rat and elucidated …
de, ru, be
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Accès ouvert
2016
article
OpenAlex
Eva Christine Bunk, Gökhan Ertaylan, Felipe Ortega, Maria Angeliki S. Pavlou et autres
Adult neural stem cells with the ability to generate neurons and glia cells are active throughout life in both the dentate gyrus (DG) and the subventricular zone (SVZ). Differentiation of adult neural stem cells is induced by cell fate determinants like the …
de, lu, nl, es, gr
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