Megumi Watanabe

Association between preoperative respiratory function and postoperative complications in patients with colorectal cancer: a retrospective study

Yuhei Ueno, Ryota Matsui, Kenta Doden, Kengo Hayashi et autres

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Complete Mitral Valve Reconstruction Using Fresh Autologous Pericardium in a Chihuahua with Infective Endocarditis: A Case Report

Noriko Isayama, Yusuke Uchimura, Kenta Sasaki, Erika Maeda et autres

In humans, surgical repair is commonly performed for infective endocarditis (IE) associated with mitral valve destruction. However, extensive valve destruction may make repair impossible and require prosthetic valve replacement. In small-breed dogs, appropriately sized prosthetic valves are lacking, and complete surgical mitral …

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Conversion Surgery for Advanced Gastric Cancer According to First-Line Treatment Strategy: A Single-Center Experience with a Focused Review of the Literature

Jun Kinoshita, Kenta Doden, Kengo Hayashi, Ryota Matsui et autres

Background/Objectives: First-line therapy for advanced gastric cancer (AGC) has evolved from cytotoxic chemotherapy to HER2-targeted and immune checkpoint inhibitor (ICI)-based regimens, yet conversion surgery (CS) outcomes across these strategies remain poorly characterized. We describe CS outcomes and prognostic factors by first-line strategy …

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GLIM-Defined Malnutrition as a Predictor of Postoperative Morbidity and Survival After Curative Resection for Upper Gastrointestinal Cancer: A Systematic Review and Meta-Analysis

Ryota Matsui, Jun Watanabe, Kazuma Rifu, Kenichi Ishibayashi et autres

Background: Malnutrition is common among patients with cancer and has been associated with unfavorable postoperative outcomes, including higher rates of complications. This study aimed to synthesize current evidence on the relationship between malnutrition, as defined by the Global Leadership Initiative on Malnutrition …

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Pan-Cancer Analysis Reveals AEBP1-Collagen Co-Expression and Its Potential Role in CAF-Mediated Tumor Stiffness

Shohei Sekiguchi, Akira Yorozu, Megumi Watanabe, Fumika Okazaki et autres

Cancer-associated fibroblasts (CAFs) are critical components of the tumor microenvironment that promote cancer progression and immune evasion. Adipocyte enhancer-binding protein 1 gene (AEBP1), which encodes aortic carboxypeptidase-like protein (ACLP), has been implicated in tissue remodeling and fibrosis, yet its role in CAF …

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Extracorporeal Membrane Oxygenation for Acute Respiratory Failure in a Dog

Noriko Isayama, Yusuke Uchimura, Kenta Sasaki, Erika Maeda et autres

A 3-year-old West Highland White Terrier presented to our hospital with dyspnea following aspiration of barium contrast medium during diagnostic imaging for a suspected esophageal foreign body (day 0). Barium contrast radiography had revealed a foreign body in the lower esophagus. During …

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Pan-Cancer Analysis Reveals AEBP1-Collagen Co-Expression and Its Potential Role in CAF-Mediated Tumor Stiffness

Shohei Sekiguchi, Akira Yorozu, Megumi Watanabe, Fumika Okazaki et autres

Cancer-associated fibroblasts (CAFs) are critical components of the tumor microenvironment that promote cancer progression and immune evasion. Adipocyte enhancer-binding protein 1 gene (AEBP1), which encodes aortic carboxypeptidase-like protein (ACLP), has been implicated in tissue remodeling and fibrosis, yet its role in CAF …

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Extracorporeal Membrane Oxygenation for Acute Respiratory Failure in a Dog

Noriko Isayama, Yusuke Uchimura, Kenta Sasaki, Erika Maeda et autres

A 3-year-old West Highland White Terrier was presented to our hospital with dyspnoea following aspiration of barium contrast medium during diagnostic imaging for a suspected oesophageal foreign body (day 0). Barium contrast radiography had revealed a foreign body in the lower oesophagus. …

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Imeglimin Alleviates High-Glucose-Induced Bioenergetic and Oxidative Stress Thereby Enhancing Intercellular Adhesion in H9c2 Cardiomyoblasts

Megumi Watanabe, Megumi Suzuki, Naruki Ohara, Toshifumi Ogawa et autres

To elucidate the effects of the new antidiabetic agent, imeglimin (Ime, 2 mM), on high-glucose-induced cellular stress in cardiac cells, its effects were compared with those of the conventional antidiabetic agent metformin (Met, 2 mM) based on various cellular pathophysiological functions. H9c2 …

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The distinct effects of metformin and imeglimin on high glucose-induced alterations in metabolic function and reactive oxygen species production in mouse Schwann cells are modulated by pemafibrate and/or fatty acid-binding proteins.

Hiroshi Ohguro, Megumi Higashide, Nami Nishikiori, Toshifumi Ogawa et autres

Background Imeglimin (Ime), the first in a novel class of antidiabetic agents, has potential therapeutic effects on diabetic peripheral neuropathy (DPN). This study aimed to evaluate and compare the effects on cellular metabolic function and reactive oxygen species (ROS) levels in high …

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Retrospective Analysis of Risk Factors Associated with Incidental Appendiceal Neoplasms in Patients with Acute Appendicitis

Susumu Doita, Fumitaka Taniguchi, Kengo Mouri, Eiki Miyake et autres

INTRODUCTION: As the nonoperative management of acute appendicitis becomes more widespread, identifying patients at high risk of appendiceal tumors is increasingly important. This study aimed to clarify the predictive factors of appendiceal tumors before appendectomy. METHODS: We retrospectively analyzed 434 patients diagnosed …

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Fatty Acid Metabolism Regulators Have Pivotal Roles in the Pathogenesis of Ovarian Carcinoma

Megumi Watanabe, Motoki Matsuura, Tatsuya Sato, Makoto Usami et autres

To study the pathological contribution of fatty acid (FA) metabolism regulators including fatty acid binding protein 4 (FABP4), FABP5, peroxisome proliferator-activated receptor alpha (PPARα), and PPARγ in ovarian carcinoma, non-cancerous human ovarian surface epithelium (HOSE) cells and two epithelial ovarian carcinoma (EOC) …

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