Aina Nadheera Abd Rahman

Somatic Mutations Associated with Aldosterone-Producing Adenomas (APAs)

Aina Nadheera Abd Rahman, Elena Azizan

Hypertension is a critical health concern as it affects millions of people worldwide and leads to increased risk factors for other diseases such as cardiovascular diseases and stroke. Hypertension is commonly categorized into primary hypertension and secondary hypertension, with the latter frequently …

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IMMUNE PROFILES IN KCNJ5-MUTANT ALDOSTERONE-PRODUCING ADENOMAS: PILOT CHARACTERISATION OF AGE AND GENDER DIFFERENCES

Amnani Aminuddin, Faeezah Abdul Latif, Aina Nadheera Abd Rahman, Muaatamarulain Mustangin et autres

Objective: Immune profiling of aldosterone-producing adenomas (APAs) has revealed profound variations in the tumour microenvironment (TME), stratified by patient age and sex. This study characterised the immune cell profile in three KCNJ5-mutant APAs from a young Asian male (26 yo), an older …

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IMMUNE MICROENVIRONMENT PROFILING OF PRIMARY ALDOSTERONISM

Elena Aisha Azizan, Noorzaileen Eileena Zaidi, Amnani Aminuddin, Siti Khadijah Syed Mohammed Nazri et autres

Objective: In recent years, remodelling of the immune microenvironment has been documented in aldosterone-producing adenomas (APAs) compared to paired adjacent adrenal cortical tissue. Around 90% of APAs harbour a somatic mutation in known aldosterone-driver genes with the majority harbouring either a KCNJ5 …

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THE MUTATIONAL LANDSCAPE OF ADRENAL GLANDS WITH ALDOSTERONE-PRODUCING LESIONS AT SINGLE-CELL RESOLUTION

Amnani Aminuddin, Aina Nadheera Abd Rahman, Faeezah Abdul Latif, Claudia Cabrera et autres

Objective: Aldosterone-producing micronodules (APMs), clusters of cells in the subcapsular regions of the adrenal cortex that autonomously express aldosterone synthase (encoded by the gene CYP11B2), are potential precursors to aldosterone-producing adenomas (APAs), which leads to excess aldosterone production and secondary hypertension. Increased …

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10055: Cardiac Disease Occurrences in Primary Aldosteronism patients at Hospital Canselor Tuanku Muhriz UKM: Comparison of Unilateral versus Bilateral Subtype and Medical Treatment versus Adrenalectomy

Aina Nadheera Abd Rahman, Megan Limbang, Hazim Fadzli, Adi Syazni Muhammed et autres

Breast Cancer in Systemic Lupus Erythematosus

M. Petri, S.C. Bae, S. Manzi, E.M. Ginzler et autres

Evidence points to a decreased breast cancer risk in systemic lupus erythematosus (SLE). We analyzed data from a large multisite SLE cohort, linked to cancer registries.

Atherosclerotic vascular events in a multinational inception cohort of systemic lupus erythematosus

R. Ramsey-Goldman, G. S. Alarcón, A. Zoma, M. B. Urowitz et autres

To describe vascular events during an 8 year follow-up in a multicentre SLE inception cohort and their attribution to atherosclerosis.

Prospective analysis of neuropsychiatric events in an international disease inception cohort of patients with systemic lupus erythematosus

R. Ramsey-Goldman, J. Romero-Diaz, J. Douglas, M. Khamashta et autres

To determine the frequency, accrual, attribution and outcome of neuropsychiatric (NP) events and impact on quality of life over 3 years in a large inception cohort of SLE patients.