Li Juel Mortensen

Circulating matrix GLA protein during puberty in healthy and central precocious puberty children

Maria Bentz Damholt, S. Faisal Ahmed, Jørgen Holm Petersen, Martin Blomberg Jensen et autres

OBJECTIVE: Matrix GLA protein (MGP) is involved in the regulation of extracellular matrix mineralisation, including bone formation. The peripubertal years are critical for linear growth and acquisition of bone mass. Emerging evidence suggests that plasma concentrations of dephosphorylated undercarboxylated MGP (dp-ucMGP) may …

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Effects of a single-dose denosumab on glucose and lipid homeostasis in young infertile men

Emil Brink Wriedt, Mads Joon Jorsal, Sam Kafai Yahyavi, Li Juel Mortensen et autres

PURPOSE: Infertile men have an increased prevalence of metabolic syndrome. Denosumab has been shown to lower HbA1c in older patients with impaired glucose tolerance. We hypothesized that denosumab will lower HbA1c in a cohort of young infertile men. METHODS: This was a …

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Longitudinal circulating procollagen-markers PRO-C1 and PRO-C2 reflect pubertal growth spurt in healthy adolescents

Li Juel Mortensen, Yi He, Martin Blomberg Jensen, Jørgen Holm Petersen et autres

INTRODUCTION: Epiphyseal growth plate development is stimulated by GH and IGF-I. Serum IGF-I is applied as an efficacy and safety marker, monitoring growth in short GH-treated children. However, IGF-I offers poor guidance to clinicians, especially in children without GHD. Thus, novel biomarkers …

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Effect of denosumab on semen quality in infertile men selected by serum level of antimüllerian hormone: a randomized controlled trial

Sam Kafai Yahyavi, Rune Holt, Mads Joon Jorsal, Gustav Wall-Gremstrup et autres

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Follicular fluid concentrations of the vitamin D metabolite 24,25(OH)2D3 are positively associated with live birth rate after assisted reproductive technology

Ireen Kooij, Rune Holt, Li Juel Mortensen, Mette Lorenzen et autres

To investigate the relationship between concentrations of vitamin D metabolites in follicular fluid and outcome of assisted reproductive technology (ART) treatment. Prospective cohort study including 116 women undergoing in vitro fertilization (IVF) or intra cytoplasmic sperm injection (ICSI) treatment. All measured vitamin …

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Effect of a single-dose denosumab on mineral homeostasis in infertile men: insights from a pilot intervention study and a randomized controlled trial

Sam Kafai Yahyavi, Rune Holt, Li Juel Mortensen, Ida Marie Boisen et autres

BACKGROUND: Denosumab, a drug that inhibits RANKL to reduce bone resorption in osteoporotic postmenopausal women, has been shown to improve semen quality in a subgroup of infertile men. This study aimed to investigate the effects of denosumab on mineral homeostasis in young …

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Soluble luteinizing hormone receptor in follicular fluid and the association with reproductive function during IVF and ICSI

Li Juel Mortensen, Mette Lorenzen, Christine Hjorth Andreassen, Ursula Bentin-Ley et autres

0.770, p < 0.0001), suggesting an extragonadal origin of sLHCGR. Follicular levels of sLHCGR were associated with follicular SHBG and free testosterone. Follicular/serum-ratio of sLHCGR was inversely associated with both serum- and follicular AMH. However, no association was found between sLHCGR and …

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Denosumab stimulates spermatogenesis in infertile men with preserved Sertoli cell capacity

Christine Hjorth Andreassen, Rune Holt, Li Juel Mortensen, Nadia Krarup Knudsen et autres

Sperm production depends on proper Sertoli-germ cell interaction, and we hypothesized that receptor activator of nuclear factor κB ligand (RANKL) activity in Sertoli cells may influence spermatogenesis. Treatment with the RANKL inhibitor denosumab, normally used to treat osteoporosis, increased testicular weight, inhibin …

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Injection of luteinizing hormone or human chorionic gonadotropin increases calcium excretion and serum PTH in males

Li Juel Mortensen, Ireen Kooij, Mette Lorenzen, Niklas Rye Jørgensen et autres

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Ovarian follicular fluid levels of phthalates and benzophenones in relation to fertility outcomes

Astrid Linnea Beck, Anders Rehfeld, Li Juel Mortensen, Mette Lorenzen et autres

Many endocrine disrupting chemicals (EDCs), for instance phthalates and benzophenones, are associated with adverse fertility outcomes and semen quality parameters. To evaluate if concentrations of selected phthalate metabolites and benzophenones measured in follicular fluid are associated with fertility outcomes (i.e., reproductive hormones, …

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List of contributors

John S. Adams, Karin Amrein, Paul Anderson, Leggy A. Arnold et autres

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Vitamin D, reproductive endocrinology, and male reproductive organ function in health and disease

Ida Marie Boisen, Rune Holt, Ireen Kooij, Sam Kafai Yahyavi et autres

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