Zhihuai Mo

Case Series of 46 Patients With Nonketotic Hyperglycemia-associated Chorea: A Retrospective Follow-up Study

Xiaoyan Wu, Ruying Fu, Chao Yuan, Rongwei Fu et autres

BACKGROUND: Nonketotic hyperglycemia-associated chorea (NKHC) is a rare but underrecognized complication of diabetes mellitus, with an unclear pathogenesis and variable clinical presentations. Recent studies highlight the role of metabolic disturbances and cerebrovascular pathophysiology in its development. RESEARCH DESIGN AND METHODS: To investigate …

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Efficacy and Safety of Dl-3-n-Butylphthalide Combined With Human Urinary Kallidinogenase in the Treatment of Acute Ischemic Stroke

Yaqian Zhang, Feng Zhou, Huiqing Li, Junjie Lei et autres

OBJECTIVES: Intravenous thrombolysis and mechanical endovascular thrombectomy are recommended for patients whose stroke onsets are within the first 6 hours; however, patients beyond this time window have very limited options. Dl-3-n-butylphthalide (NBP) and human urinary kallidinogenase (HUK) have shown potential clinical benefits …

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Eicosapentaenoic acid prevents inflammation induced by acute cerebral infarction through inhibition of NLRP3 inflammasome activation

Zhihuai Mo, Chaogang Tang, Huiqing Li, Junjie Lei et autres

OBJECTIVE: Acute cerebral infarction (ACI) is the most common type of acute cerebrovascular diseases resulting in high rate of death and disability. Numerous evidences show that inflammation is the leading cause of ischemic brain injury, thus anti-inflammatory therapy is an attractive candidate …

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Long noncoding RNA CDKN2B‐AS1 interacts with transcription factor BCL11A to regulate progression of cerebral infarction through mediating MAP4K1 transcription

Junjie Lei, Huiqing Li, Zhihuai Mo, Kejia Liu et autres

ABSTRACT The effective therapeutic approach of cerebral infarction is limited because of its underlying complexity. Recently, multiple long noncoding RNAs (lncRNAs) have been identified in the pathogenesis of cerebral infarction. Here, the current study aims to explore the interaction among lncRNA cyclin‐dependent …

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Connectivity map identifies luteolin as a treatment option of ischemic stroke by inhibiting MMP9 and activation of the PI3K/Akt signaling pathway

Shijian Luo, Huiqing Li, Zhihuai Mo, Junjie Lei et autres

This study aimed to explore potential new drugs in the treatment of ischemic stroke by Connectivity Map (CMap) and to determine the role of luteolin on ischemic stroke according to its effects on matrix metalloproteinase-9 (MMP9) and PI3K/Akt signaling pathway. Based on …

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Application of Doctor-Nurse-Patient Integration Management Mode in Patients with Endometriosis.

Yao Chen, Zhihuai Mo, Jianyong Cao, Zhaojuan Su et autres

BACKGROUND: To investigate the effect of applying doctor-nurse-patient integration management mode to patients with endometriosis (EMT). METHODS: A total of 160 patients with EMT from the Department of Neurology of The Fifth Affiliated Hospital Sun Yat-Sen University from January 2017 to October …

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Edaravone attenuates neuronal apoptosis in hypoxic-ischemic brain damage rat model via suppression of TRAIL signaling pathway

Chunyi Li, Zhihuai Mo, Junjie Lei, Huiqing Li et autres

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