Raed A. Dweik

Transhepatic Gradients Reveal Selective Hepatic Processing Defects With Systemic Consequences in Cirrhosis

Graham Stockdale, A Fawaz, Marla Bashour, Kulwant S. Aulak et autres

Background/Objectives: The cirrhotic liver's metabolic capacity remains incompletely characterized, particularly its role in shaping portal metabolite signals that reach the systemic circulation. Transjugular intrahepatic portosystemic shunt (TIPS) placement allows paired portal and right atrial sampling to estimate transhepatic gradients. Methods: We performed …

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Endotypes of Vascular Health Predict Transplantation‐Free Survival in Pulmonary Hypertension

Samar Farha, Bo Hu, Ruoying Chen, John Barnard et autres

BACKGROUND: The current classification of pulmonary hypertension (PH), based largely on expert opinion, has limitations in prognostication and guiding therapies. We hypothesize that novel PH clusters that predict survival will reveal mechanistic phenotypes associated with biomarkers of vascular health across all PH …

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CD248 activates TGF-β receptor I to promote vascular remodeling in pulmonary arterial hypertension

L. Jones, Hannah J. McIntire-Ray, Angela N. Morales, Shia Vang et autres

I. ABSTRACT Background Pulmonary arterial hypertension (PAH) is a debilitating cardiopulmonary disease characterized by progressive remodeling of the pulmonary vasculature. Pathologic transforming growth factor-β (TGF-β) signaling is an essential driver of vascular remodeling in PAH. While global inhibitors of TGF-β exist, their …

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PET Molecular Imaging and Theranostics in Lung Diseases

Majid Assadi, Malik Juweid, Danny David Jonigk, Jan Wilhelm Spillner et autres

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26-A-12657-ACC A COMPARISON OF RE-HOSPITALIZATION OR DEATH BETWEEN PATIENTS HOSPITALIZED IN THE BRICK AND MORTAR HOSPITAL VERSUS VIRTUAL HOSPITAL AT HOME

Harsh H. Patolia, Alexandra Manaila, Faysal I. Massad, Yifan Wang et autres

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ATS 2025 Interview: Raed Dweik

Raed A. Dweik

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A Simplified Procedure to Isolate Endothelial Cells From Pulmonary Arterial Blood

Adriano R. Tonelli, Liping Tian, Deborah L Paul, Lori A. Mavrakis et autres

Abstract RATIONALE. Pulmonary arterial hypertension (PAH) is a progressive condition marked by increased pressures in the pulmonary arteries, which can lead to right heart failure and death. Research into the mechanisms of PAH is challenging since a) animal models fail to precisely …

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Transcriptomic Analysis of Endothelial and Smooth Muscle Cells Isolated From Patients With Pulmonary Arterial Hypertension May Aid in Understanding Responses to Therapy

Adriano R. Tonelli, Liping Tian, Deborah L Paul, Lori A. Mavrakis et autres

Abstract RATIONALE: Pulmonary arterial hypertension (PAH) is characterized by vascular remodeling driven by endothelial dysfunction, smooth muscle proliferation, and development of plexiform lesions. The abnormal vascular remodeling leads to a higher resistance to blood flow, straining the right side of the heart …

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Protecting the Future of Medical Innovation: Balancing Fiscal Responsibility with the Need for National Institutes of Health and Federal Health Funding

Irina Petrache, Raed A. Dweik, Michelle Ng Gong, Jesse Roman et autres

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Protecting the Future of Medical Innovation: Balancing Fiscal Responsibility with the Need for National Institutes of Health and Federal Health Funding

Irina Petrache, Raed A. Dweik, Michelle Ng Gong, Jesse Roman et autres

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Protecting the Future of Medical Innovation: Balancing Fiscal Responsibility with the Need for National Institutes of Health and Federal Health Funding

Irina Petrache, Raed A. Dweik, Michelle Ng Gong, Jesse Roman et autres

us (code pays fourni par la source)

Protecting the Future of Medical Innovation: Balancing Fiscal Responsibility with the Need for National Institutes of Health and Federal Health Funding

Irina Petrache, Raed A. Dweik, Michelle Ng Gong, Jesse Roman et autres

us (code pays fourni par la source)