Longquan Shao

Beyond antimicrobials: Ecological nano‐strategies for rebalancing dysbiotic oral microbial homeostasis

Chen Hu, Aohan Luan, Yujun Yang, Linlin Wang et autres

Abstract Oral microbial homeostasis is a stable equilibrium state of the ecological community of oral microorganisms formed through the dynamic interactions between the oral microorganisms and the host's oral ecosystem. Its disruption can lead to opportunistic pathogenic infections or refractory infectious diseases …

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Two‐Dimensional Carbon‐Based Nanozymes: Synthesis, Catalytic Mechanisms and Biomedical Applications

Bichong Luo, Wenjing Liu, Haiyun Luo, Qinying Wang et autres

Natural enzymes are essential for biomedical applications but are limited by high costs, instability, and strict storage conditions. Nanozymes have emerged as promising artificial alternatives, among which two-dimensional carbon-based nanozymes (2D CBNs) are attractive because their atomically thin geometry, highly exposed catalytic …

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Activation of Nrf2 with natural flavonoids and mesenchymal stromal/stem cells: mechanisms and therapeutic potential for inflammatory diseases

Fengqing Shang, Yanling Qu, Zhe Wang, Lingjuan Dong et autres

Redox balance is crucial for maintaining normal physiological functions. Its disruption by oxidative stress can trigger or exacerbate a series of pathological cascades, ultimately contributing to various chronic diseases, particularly inflammatory disorders. Inhibiting oxidative stress and its associated pathological cascades may alleviate …

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Immunological mechanisms and immunotherapeutic strategies for the maternal-fetal interface diseases during pregnancy

Shuo Zheng, Yulin Zhang, Yi Xing, Z Zhang et autres

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Tooth‐Bone Integrated Organoids via Bioactive Glass Mediated Dual Interface Bonding and Rapid Osteogenesis

Xu Wu, Yi Yang, Haohui Huang, Yonghao Qiu et autres

ABSTRACT Large maxillofacial bone defects severely impair oral function and aesthetics, and current treatments involving autologous bone grafting followed by prosthetic restoration are associated with high surgical trauma and prolonged rehabilitation. Herein, we present a tooth‐bone integrated organoid (TBO) strategy that synchronously …

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Mechanistic analysis of abnormal activation of the RANKL-RANK signaling axis in diabetic bone injury

Yunhe Lin, Shukurov Kamoliddin, Jawad Hussain, Guangguang Yang et autres

Objective: Based on bioinformatics analysis methods, this study aims to investigate the mechanism underlying the abnormal activation of the RANKL-RANK signaling axis in diabetic bone injury, as well as its role in the processes of excessive osteoclast differentiation and bone resorption. This …

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Mechanistic analysis of abnormal key enzymes in the arginine and proline metabolic pathways in diabetic bone injury

Yunhe Lin, Shukurov Kamoliddin, Jawad Hussain, Guangguang Yang et autres

Objective: Based on the GSE189112 dataset, this study aimed to systematically analyze the abnormal expression patterns of the arginine and proline metabolic pathways in a streptozotocin (STZ)-induced diabetic model, clarify the regulatory mechanism of abnormal key enzymes in this pathway on diabetic …

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Perspective opportunities and challenges in translating dental materials into clinical practice

Yi Ma, Ye Tao, Ling Li, Yongsheng Zhou et autres

The clinical translation of dental materials presents significant opportunities, driven by increasing market demand, supportive regulatory frameworks, and advancements in digital and additive manufacturing technologies. These factors facilitate enhanced personalization, improved biocompatibility, and superior aesthetic and mechanical properties of dental products. However, …

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin et autres

Abstract Neurodegenerative diseases (NDs) are a major cause of disability and the second leading cause of death worldwide. The progression of NDs is intricately linked to the disruption of immune homeostasis, which is characterized by excessive activation and infiltration of immune cells. …

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Decoding orofacial pain: a translational review of mechanisms and novel therapies

Yiyuan Kang, Yongshui Fu, Jia Liu, Longquan Shao

Orofacial pain encompasses a diverse group of disorders that pose a significant clinical challenge, often progressing from acute to chronic conditions due to a disconnect between clinical diagnosis and underlying pathophysiology. This review provides a synthesis of the mechanisms driving this transition …

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Application of Responsive Intelligent Biomaterials in Regenerative Medicine

Wenqiang Xie, Yuan Su, Ruiqi Zhang, Sijia Li et autres

Responsive intelligent biomaterials, characterized by their ability to sense and respond to external or internal stimuli, have emerged as promising candidates in regenerative medicine (RM). RM aims to replace or regenerate damaged human cells, tissues, or organs to restore normal function. However, …

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Soluble Sema4D From γδ T Cells Exerts Osteoblast Inhibition via Plexin‐B/ mTOR Signalling Contributing to Pathogenesis of Bisphosphonate‐Related Osteonecrosis of the Jaws

Lingling Ou, Shijia Qiao, Xiner Tan, Hui Huang et autres

ABSTRACT Bisphosphonate‐related osteonecrosis of the jaw (BRONJ) is a severe complication in patients undergoing long‐term bisphosphonate therapy, while our knowledge on the pathogenesis of BRONJ is far from sufficient. Gamma delta (γδ) T cells predominantly distribute in mucosal tissues and play an …

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