Daniel D. Swartz

Immune-mediated regeneration of cell-free vascular grafts in an ovine model

Bita Nasiri, Ramachandran Karthik, Sai Harsha Bhamidipati, Yulun Wu et autres

We developed acellular tissue engineered vessels (ATEV) using small intestine submucosa (SIS) incorporating heparin and a novel protein named H2R5. ATEVs were implanted into the arterial circulation of an ovine animal model, demonstrating high primary patency rates over a period of three …

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Cell‐Free Vascular Grafts That Grow with the Host

Bita Nasiri, Sindhu Row, Randall J. Smith, Daniel D. Swartz et autres

Cell-free small diameter vascular grafts, based on small intestinal submucosa (SIS) functionalized with heparin and vascular endothelial growth factor (VEGF) manufactured and implanted successfully into the arterial system of neonatal lambs, where they remained patent and grew in size with the host …

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Endothelialization of arterial vascular grafts by circulating monocytes

Randall J. Smith, Bita Nasiri, Julien Kann, Donald Albert Yergeau et autres

Recently our group demonstrated that acellular tissue engineered vessels (A-TEVs) comprised of small intestinal submucosa (SIS) immobilized with heparin and vascular endothelial growth factor (VEGF) could be implanted into the arterial system of a pre-clinical ovine animal model, where they endothelialized within …

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Use of a selective type V phosphodiesterase inhibitor, PAPiSOL (E4021), in the treatment of pulmonary hypertension in the canine.

Daniel D. Swartz, ra Sexton, Leslie I. Curtin, Bryan J. Perry

Pulmonary hypertension (PH) is a progressive disease characterized by chronic elevation in pulmonary arterial pressure (PAP). This disease is poorly recognized in dogs with limited economical and effective treatment available. The secondary messenger cyclic guanosine monophosphate (cGMP), which regulates pulmonary and systemic …

Cell-free vascular grafts: Recent developments and clinical potential

Sindhu Row, Ana Santandreu, Daniel D. Swartz, Stelios T. Andreadis

Recent advances in vascular tissue engineering have led to the development of cell-free grafts that are available off-the-shelf for on demand surgery. Challenges associated with cell-based technologies including cell sourcing, cell expansion and long-term bioreactor culture motivated the development of completely cell-free …

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Animal models of cardiovascular disease as test beds of bioengineered vascular grafts

Sindhu Row, Daniel D. Swartz, Stelios T. Andreadis

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Sharing Progress in Neonatal (SPIN) Lung and Brain

Bashi̇r Abdulkadi̇r, Andrew J. Nelson, Tom Skeath, Emma C. L. Marrs et autres

Hemodynamics and Gas Exchange during Chest Compressions Following Perinatal Asphyxial Cardiac Arrest: Table.

Payam Vali, Munmun Rawat, Praveen Kumar Chandrasekharan, Sylvia F. Gugino et autres

Continuous End-Tidal Carbon Dioxide Monitoring during Resuscitation of Asphyxiated Term Lambs

Praveen Kumar Chandrasekharan, Munmun Rawat, Jayasree Chandrasekharan Nair, Sylvia F. Gugino et autres

BACKGROUND: The Neonatal Resuscitation Program (NRP) recommends close monitoring of oxygenation during the resuscitation of newborns using a pulse oximeter. However, there are no guidelines for monitoring carbon dioxide (CO2) to assess ventilation. Considering that cerebral blood flow (CBF) correlates directly with …

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Neonatal resuscitation adhering to oxygen saturation guidelines in asphyxiated lambs with meconium aspiration

Munmun Rawat, Praveen Kumar Chandrasekharan, Daniel D. Swartz, Bobby Mathew et autres

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Successful endothelialization and remodeling of a cell-free small-diameter arterial graft in a large animal model

Maxwell T. Koobatian, Sindhu Row, Randall J. Smith, Carmon Koenigsknecht et autres

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Surgical Technique for the Implantation of Tissue Engineered Vascular Grafts and Subsequent In Vivo Monitoring

Maxwell T. Koobatian, Carmon Koenigsknecht, Sindhu Row, Stelios T. Andreadis et autres

The development of Tissue Engineered Vessels (TEVs) is advanced by the ability to routinely and effectively implant TEVs (4-5 mm in diameter) into a large animal model. A step by-step protocol for inter-positional placement of the TEV and real-time digital assessment of …

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