Giulia Lucignani

Spontaneous closure of an atraumatic cervical spinal arteriovenous fistula in a pediatric patient

Guglielmo Paolantonio, Alessia Carboni, Michela Ada Noris Ferilli, Carlotta Ginevra Nucci et autres

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Long-term outcomes in pediatric brain AVMs: beyond radiological cure

Francesco M C Lioi, Alessandro De Benedictis, Davide Luglietto, Franco Randi et autres

Background Brain AVMs are typically considered cured after angiographic confirmation of nidus obliteration. However, in pediatric patients, recurrence can occur many years later, underscoring the need for long-term clinical surveillance. Event-free survival (EFS) represents a complementary, exploratory metric of therapeutic success that …

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Bacterial Meningoencephalitis in Newborns

Alessia Guarnera, Giulia Moltoni, Francesco Dellepiane, Giulia Lucignani et autres

Bacterial meningoencephalitis in newborns is a severe and life-threatening pathology, which results from meningeal infection and the subsequent involvement of the brain parenchyma. The severity of the acute onset of symptoms and the risk of neurodevelopmental adverse sequelae in children strongly depend …

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MRI scan with the “feed and wrap” technique and with an optimized anesthesia protocol: a retrospective analysis of a single-center experience

Giulia Moltoni, Giulia Lucignani, Stefania Sgrò, Alessia Guarnera et autres

Introduction: MRI examinations in the pediatric population require acquiring motionless images in the safest possible manner. At our institute, we have developed a protocol called "Good Practice" aimed at avoiding anesthesia in newborns and infants through the use of the "feed and …

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Plasmatic profiles of cytokines/chemokines, glial fibrillary acidic protein (GFAP) and MRI brain damage in neonates with hypoxic ischemic encephalopathy (HIE)

Cinzia Auriti, Vito Mondı̀, Fiammetta Piersigilli, Laura Timelli et autres

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Congenital Malformations of the Eye: A Pictorial Review and Clinico-Radiological Correlations

Alessia Guarnera, Paola Valente, Luca Pasquini, Giulia Moltoni et autres

Congenital malformations of the eye represent a wide and heterogeneous spectrum of abnormalities that may be part of a complex syndrome or be isolated. Ocular malformation severity depends on the timing of the causative event during eye formation, ranging from the complete …

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Author Correction: Differential diagnosis of neurodegenerative dementias with the explainable MRI based machine learning algorithm MUQUBIA

Silvia De Francesco, Claudio Crema, Damiano Archetti, Cristina Muscio et autres

In the original version of this Article the consortia names were incorrectly given as “for the ADNI, Frontotemporal Lobar Degeneration Neuroimaging; NIA Alzheimer’s Disease Centers; and the RIN – Neuroimaging Network”. The correct consortium name is “the RIN – Neuroimaging Network”.

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Differential diagnosis of neurodegenerative dementias with the explainable MRI based machine learning algorithm MUQUBIA

Silvia De Francesco, Claudio Crema, Damiano Archetti, Cristina Muscio et autres

Biomarker-based differential diagnosis of the most common forms of dementia is becoming increasingly important. Machine learning (ML) may be able to address this challenge. The aim of this study was to develop and interpret a ML algorithm capable of differentiating Alzheimer's dementia, …

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A New Pattern of Brain and Cord Gadolinium Enhancement in Molybdenum Cofactor Deficiency: A Case Report

Giulia Lucignani, Leonardo Vattermoli, Maria Camilla Rossi‐Espagnet, Alessia Guarnera et autres

Molybdenum cofactor deficiency (MoCD) is a rare and severe autosomal recessive in-born error of metabolism caused by the mutation in MOCS1, MOCS2, MOCS3 or GEPH genes, with an incidence ranging between 1 in 100,000 and 200,000 live births. The clinical presentation with …

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Neurodevelopmental and genetic findings in neonates with intracranial arteriovenous shunts: A case series

Francesca Campi, Domenico Umberto De Rose, Flaminia Pugnaloni, Sara Ronci et autres

Background: Despite the latest advances in prenatal diagnosis and postnatal embolization procedures, intracranial arteriovenous shunts (AVSs) are still associated with high mortality and morbidity rates. Our aim was to evaluate the presentation and clinical course, the neurodevelopmental outcome, and the genetic findings …

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Correlation of Plasmatic Profiles of Inflammatory Cytokines/Chemokines and GFAP with Brain Damage Detected at MRI in Neonates with Hypoxic Ischemic Encephalopathy (HIE) Treated with Therapeutic Hypothermia: A Preliminary Study

Cinzia Auriti, Fiammetta Piersigilli, Vito Mondı̀, Laura Timelli et autres

Background & Objective. Perinatal hypoxia acutely triggers the release of cytokines and chemokines from neurons, astrocytes and microglia. In response to hypoxia-ischemia resting/ramified microglia proliferate and undergo activation, with the production of proinflammatory molecules. The brain damage extension seems to be related …

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Predictive Value of MRI in Hypoxic-Ischemic Encephalopathy Treated with Therapeutic Hypothermia

Alessia Guarnera, Giulia Lucignani, Chiara Parrillo, Maria Camilla Rossi‐Espagnet et autres

BACKGROUND: Hypoxic-ischemic encephalopathy (HIE) is a severe pathology, and no unique predictive biomarker has been identified. Our aims are to identify associations of perinatal and outcome parameters with morphological anomalies and ADC values from MRI. The secondary aims are to define a …

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