Konstantin Doberer

Torque Teno virus is predictive for malignancies after kidney transplantation

Carsten T. Herz, Frederik Haupenthal, Felix Herkner, Konstantin Doberer et autres

BACKGROUND AND HYPOTHESIS: Malignancy, driven by the effects of immunosuppression, is a major complication following kidney transplantation. The widespread and non-pathogenic TT virus (TTV) has emerged as a surrogate of the immune status of its host, with prior studies linking TTV load …

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Torque teno virus (TTV) as a promising biomarker in gynaecologic cancer therapy: preliminary findings of an ongoing prospective validation study

Thomas Bartl, Patrick Zommer, Arina Onoprienko, Robert Straßl et autres

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Immune Monitoring Goes Viral – Torque Teno Virus for Immunologic Risk Stratification After Kidney Transplantation

Konstantin Doberer, Sebastian Kapps, Frederik Haupenthal, Gregor Bond

Using biomarkers to tailor immunosuppressive therapy after kidney transplantation was proposed to improve clinical care. Timely and individual adaptions of immunosuppression could reduce therapy-related side effects, such as infections, cardiovascular morbidity and malignancy, and further lower the risk of allograft rejection. Despite …

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Statistical analysis plan for TTVguideIT—a multicentre, patient- and assessor-blinded, non-inferiority, randomised and controlled phase II trial to compare standard and Torque Teno virus-guided immunosuppression in kidney transplant recipients in the first year after transplantation

Felix Herkner, Frederik Haupenthal, Sebastian Kapps, Konstantin Doberer et autres

BACKGROUND: Non-interventional studies indicate an association between Torque Teno Virus (TTV) load in peripheral blood and immunosuppression related outcomes in kidney transplant recipients. This makes it a promising biomarker for guiding immunosuppression after kidney transplantation. The primary objective of the current trial …

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#2342 Long term monitoring of torque teno virus load for the detection of infections in kidney transplantation

Sebastian Kapps, Frederik Haupenthal, Konstantin Doberer, Gregor Bond

Abstract Background and Aims Personalized balance of immunosuppression is crucial to prevent organ rejection and infections in kidney transplant recipients. Plasma load of the non-pathogenic and highly prevalent torque teno virus (TTV) has been suggested to assess the state of immunosuppression. A …

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#2327 Monitoring of adherence to immunosuppressive drugs by electronic healthcare data in kidney transplant recipients

Sebastian Kapps, Frederik Haupenthal, Konstantin Doberer, Gregor Bond

Abstract Background and Aims Medication non-adherence to immunosuppressive drugs is a major challenge in the management of kidney transplant recipients and a major risk factor for rejection and early graft loss. Utilizing electronic healthcare data in the form of pharmacy refill records …

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#3653 Health-related quality of life in the first year post kidney transplantation – a cohort study

Habiba A. Ahmed, Frederik Haupenthal, Konstantin Doberer, Sebastian Kapps et autres

Abstract Background and Aims For patients suffering from end-stage renal disease, a kidney transplantation is the treatment of choice to improve health-related quality of life (HRQOL). An in-depth understanding of individual factors affecting HRQOL might help to develop strategies to support the …

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#2402 Torque teno virus is associated with an increased risk for malignancies after kidney transplantation

Carsten T. Herz, Frederik Haupenthal, Konstantin Doberer, Sebastian Kapps et autres

Abstract Background and Aims The risk for malignancies is increased after kidney transplantation due to immunosuppression. Torque teno virus (TTV) is a ubiquitous and non-pathogenic virus which reflects the immunocompetence of its host. TTV load has been shown to be associated with …

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#1281 Torque teno virus load in kidney transplantation: association with donor and recipient characteristics and clinical follow-up data

Katharina A. Mayer, Frederik Haupenthal, Sebastian Kapps, Konstantin Doberer et autres

Abstract Background and Aims The apathogenic and torque teno virus (TTV) is associated with the state of immunosuppression in solid organ transplant recipients. After kidney transplantation, quantification of TTV load may serve as a risk stratification tool for allograft rejection and infectious …

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Self-reported non-adherence to immunosuppressive medication detected by the BAASIS predicts allograft rejections in kidney transplant recipients

Frederik Haupenthal, Konstantin Doberer, Sebastian Kapps, Johannes Kläger et autres

BACKGROUND: After kidney transplantation adherence to immunosuppressive medication is crucial for graft survival and its assessment requires valid measurements. The Basel Assessment of Adherence-to Immunosuppressive Medications Scale (BAASIS) is a validated self-report tool to detect non-adherence, however, its ability to predict clinically …

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Disseminated infection with Candida dubliniensis after ravulizumab and treatment with rezafungin – a case report

Felix Lötsch, Michael Eder, Haris Omić, Konstantin Doberer et autres

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Cilgavimab and tixagevimab as pre-exposure prophylaxis in vaccine non-responder kidney transplant recipients during a period of prevalent SARS-CoV-2 BA.2 and BA.4/5 variants—a prospective cohort study (RESCUE-TX)

Roman Reindl‐Schwaighofer, Andreas Heinzel, Lukas Raab, Robert Straßl et autres

BACKGROUND: The response to severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) vaccination is severely impaired in patients on maintenance immunosuppression after kidney transplantation. METHODS: We conducted a prospective cohort study of 194 kidney transplant recipients (KTR) who exhibited no response to …

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