Maria Salatiello

Next-generation sequencing using a targeted gene panel in advanced solid tumors: five years of experience from an Italian referral institution

Pasquale Pisapia, Antonino Iaccarino, Caterina De Luca, Francesco Pepe et autres

AIMS: Next generation sequencing (NGS) represents the "holy grail" for the diagnostic algorithm for advanced solid tumors. In our experience, we commonly use our customized DNA-based NGS panel (namely, SiRe®). The aim of this study was to assess the efficiency of our …

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Cytological Features of Metastatic Clear Cell Renal Cell Carcinoma Diagnosed on Cytology: A Single-Center Experience with Literature Review

Isabella Sorice, Anna Maria Carillo, Maria Salatiello, Pasquale Pisapia et autres

INTRODUCTION: Renal cell carcinoma frequently metastasizes to multiple sites, which often poses significant diagnostic challenges, particularly when the primary tumor is unknown or occult. This retrospective study analyzed 43 fine-needle aspiration (FNA) cases of metastatic ccRCC from a single institution to characterize …

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Evaluation of a New Ethanol-Based Preservative Medium for Liquid-Based Cervical Cytology: A Performance Pilot Study for Molecular Applications

Floriana Conticelli, Pasquale Pisapia, Antonino Iaccarino, Maria Salatiello et autres

Background: Since liquid-based cytology (LBC) has replaced the conventional Papanicolaou test in cervical cancer screening programs, pre-analytical procedures—particularly the choice of LBC collection media—have become crucial to ensure the accuracy of high-risk (HR) HPV DNA testing. This study aims to evaluate whether …

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Clear Cell Neoplasm in Salivary Gland FNA ? Maybe It’s From Kidney!

Isabella Sorice, Anna Maria Carillo, Maria Salatiello, Caterina De Luca et autres

This article reports a rare case of metastatic clear cell renal cell carcinoma presenting as a parotid gland mass, clinically and cytologically mimicking a primary salivary gland neoplasm. It underscores the diagnostic value of integrating cytological evaluation with clinical history and immunocytochemical …

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Abstract 6722: OFD1 as a novel biomarker in cholangiocarcinoma: insights into ciliary dysfunction and tumor growth

Fabiola Piscopo, Anna Barbato, Massimiliano Salati, Carla Pollastro et autres

Abstract Cholangiocarcinoma (CCA) is a rare and aggressive solid tumor originating from cholangiocytes lining the biliary ducts. It is the second most common primary hepatic malignancy, with an increasing global incidence and limited therapeutic options. Recent studies suggest that the primary cilium …

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A challenging case of enteric-type lung adenocarcinoma metastatic to the thyroid harboring RET-fusion diagnosed on fine-needle aspiration

Anna Maria Carillo, Caterina De Luca, Mariantonia Nacchio, Maria Salatiello et autres

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Interventional cytopathologist perspective on the Milan System Classification: a study on 929 consecutive salivary gland fine-needle aspirations with a focus on challenging diagnostic categories

Anna Maria Carillo, Isabella Sorice, Maria Salatiello, Rosa Maria Di Crescenzo et autres

Background: Although the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) has improved the diagnosis and management of salivary gland lesions, determining the risk of malignancy (ROM) for AUS and SUMP categories remains challenging. We investigated the role of interventional cytopathologists in …

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Machine learning-based discrimination of benign and malignant breast lesions on US: The contribution of shear-wave elastography

Ludovica Rita La Rocca, Martina Caruso, Arnaldo Stanzione, Nicola Rocco et autres

PURPOSE: To build and validate a combined radiomics and machine learning (ML) approach using B-mode US and SWE images to differentiate benign from malignant solid breast lesions (BLs) and compare its performance with that of an expert radiologist. METHODS: Patients with at …

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57P Integrative analysis of the genomic and transcriptomic landscape identifies ciliary genes as a therapeutic target in bile duct cancer

Pietro Carotenuto, Fabio Piscopo, Anna Barbato, Carla Pollastro et autres

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The evolving role of interventional cytopathology from thyroid FNA to NGS: Lessons learned at Federico II University of Naples

Elena Vigliar, Anna Maria Carillo, Mariantonia Nacchio, Domenico Cozzolino et autres

Fine-needle aspiration (FNA) guided by ultrasound (US) has emerged as a highly precise diagnostic method for managing thyroid nodules, significantly diminishing unnecessary surgeries. The effectiveness of US-guided FNA is high when a single specialist performs the FNA procedure and the microscopy. This …

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A MiR181/Sirtuin1 regulatory circuit modulates drug response in biliary cancers

Anna Barbato, Fabiola Piscopo, Massimiliano Salati, Carla Pollastro et autres

Despite recent advances, biliary tract cancer (BTC) remains one of the most lethal tumor worldwide due to late diagnosis, limited therapeutic strategies and resistance to conventional therapies. In recent years, high-throughput technologies have enabled extensive genome, and transcriptome sequencing unveiling, among others, …

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Interobserver variability in cytopathology: How much do we agree?

Gennaro Acanfora, Anna Maria Carillo, Filippo Dello Iacovo, Maria Salatiello et autres

Interobserver variability remains a major challenge for cytopathologists despite the development of standardized reporting and classification systems. Indeed, whereas moderate-to-good interobserver agreement is generally achievable when the differential diagnosis between benign and malignant entities is straightforward, high levels of variability make the …

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