Accès ouvert
2025
article
OpenAlex
Megan J. R. Yeo, Olivia Zhang, Xiaowen Xie, Eunju Nam et autres
Abstract UM171 is a potent agonist of ex vivo human haematopoietic stem cell self-renewal 1 . By co-opting KBTBD4, a substrate receptor of the CUL3–RING E3 ubiquitin ligase (CRL3) complex, UM171 promotes the degradation of the LSD1–CoREST corepressor complex, thereby limiting haematopoietic …
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Accès ouvert
2025
article
OpenAlex
Xiaowen Xie, Olivia Zhang, Megan J. R. Yeo, Ceejay Lee et autres
Abstract Cancer mutations can create neomorphic protein–protein interactions to drive aberrant function 1,2 . As a substrate receptor of the CULLIN3-RING E3 ubiquitin ligase complex, KBTBD4 is recurrently mutated in medulloblastoma 3 , the most common embryonal brain tumour in children 4 …
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Accès ouvert
2024
preprint
OpenAlex
Megan J. R. Yeo, Olivia Zhang, Xiaowen Xie, Eunju Nam et autres
UM171 is a potent small molecule agonist of ex vivo human hematopoietic stem cell (HSC) self-renewal, a process that is tightly controlled by epigenetic regulation. By co-opting KBTBD4, a substrate receptor of the CULLIN3-RING E3 ubiquitin ligase complex, UM171 promotes the degradation …
us, it
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Accès ouvert
2024
preprint
OpenAlex
Xiaowen Xie, Olivia Zhang, Megan J. R. Yeo, Ceejay Lee et autres
Abstract Cancer mutations can create neomorphic protein-protein interactions to drive aberrant function 1 . As a substrate receptor of the CULLIN3-RBX1 E3 ubiquitin ligase complex, KBTBD4 is recurrently mutated in medulloblastoma (MB) 2 , the most common embryonal brain tumor in children, …
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Accès ouvert
2022
article
OpenAlex
Katherine T. Grasso, Soumya Jyoti Singha Roy, Arianna O. Osgood, Megan J. R. Yeo et autres
High Resolution Image Download MS PowerPoint Slide The Escherichia coli tyrosyl-tRNA synthetase (EcTyrRS)/tRNA EcTyr pair offers an attractive platform for genetically encoding new noncanonical amino acids (ncAA) in eukaryotes. However, challenges associated with a eukaryotic selection system, which is needed to engineer …
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Accès ouvert
2022
article
OpenAlex
Pallavi M. Gosavi, Kevin Chun-Ho Ngan, Megan J. R. Yeo, Cindy Su et autres
Targeted protein degradation (TPD) holds immense promise for drug discovery, but mechanisms of acquired resistance to degraders remain to be fully identified. Here, we used clustered regularly interspaced short palindromic repeats (CRISPR)-suppressor scanning to identify mechanistic classes of drug resistance mutations to …
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Accès ouvert
2021
preprint
OpenAlex
Pallavi M. Gosavi, Kevin Chun-Ho Ngan, Megan J. R. Yeo, Cindy Su et autres
Abstract Targeted protein degradation (TPD) holds immense promise for drug discovery but mechanisms of acquired resistance to degraders remain to be fully identified. Here we used CRISPR-suppressor scanning to identify mechanistic classes of drug resistance mutations to molecular glue degraders in GSPT1 …
us
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Accès ouvert
2021
preprint
OpenAlex
Katherine T. Grasso, Soumya Jyoti Singha Roy, Megan J. R. Yeo, Chintan Soni et autres
Abstract The E. coli tyrosyl-tRNA synthetase (EcTyrRS)/tRNA EcTyr pair offers an attractive platform to genetically encode new noncanonical amino acids (ncAA) in eukaryotes. However, challenges associated with a eukaryotic selection system, which is needed for its engineering, has impeded its success in …
us
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Accès ouvert
2021
article
OpenAlex
Katherine T. Grasso, Megan J. R. Yeo, Christen M. Hillenbrand, Elise D. Ficaretta et autres
The ability to engineer the substrate specificity of natural aminoacyl-tRNA synthetase/tRNA pairs facilitates the site-specific incorporation of noncanonical amino acids (ncAAs) into proteins. The Methanocaldococcus jannaschii -derived tyrosyl-tRNA synthetase (MjTyrRS)/tRNA pair has been engineered to incorporate numerous ncAAs into protein expressed in …
us
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Accès ouvert
2019
preprint
OpenAlex
Katherine T. Grasso, Megan J. R. Yeo, Christen M. Hillenbrand, Elise D. Ficaretta et autres
Abstract The ability to engineer the substrate specificity of natural aminoacyl-tRNA synthetase/tRNA pairs facilitates the site-specific incorporation of noncanonical amino acids (ncAAs) into proteins. The Methanocaldococcus jannaschii derived tyrosyl-tRNA synthetase (MjTyrRS)/tRNA pair has been engineered to incorporate numerous ncAAs into protein expressed …
us
(code pays fourni par la source)