Wesam Aldosoky

26-A-13787-ACC DEEP VEIN THROMBOSIS INFLAMMATION IS ASSOCIATED WITH A HEIGHTENED RISK OF POST-THROMBOTIC SYNDROME - A PROSPECTIVE COHORT STUDY

Jamie W. Bellinge, Rachel Pam Greenerger Rosovsky, Shady Abohashem, Hui Chong Lau et autres

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Beyond BMI: the predictive value of body roundness index for cardiovascular mortality and related disparities: a national cohort study of US adults

Mohamed K. Ibrahim, Ibrahim Hassan, Hashim M. AlHammouri, Ramez Barsoom et autres

AIMS: Obesity, particularly visceral adiposity, is a key driver of cardiovascular mortality (CVM), yet conventional measures such as body mass index (BMI) inadequately capture fat distribution. The Body Roundness Index (BRI) is a novel anthropometric measure integrating waist circumference and height to …

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Depression and Anxiety Associate With Adverse Cardiovascular Events via Neural, Autonomic, and Inflammatory Pathways

Shady Abohashem, Iqra Qamar, Simran Grewal, Giovanni Civieri et autres

BACKGROUND: Depression is linked to major adverse cardiac events (MACE), yet the role of stress-related neural activity–previously implicated in stress and anxiety in mediating this association remains unclear. Because anxiety and depression frequently co-occur and share neurobiological pathways, we hypothesized that the …

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Abstract 4363608: Reversal of Decline in Premature Cardiac Arrest Mortality: Demographic and Regional Trends in the United States, 1999–2021

Arindam Bagga, Fathima Shehnaz Ayoobkhan, Tarun Parvataneni, Wesam Aldosoky et autres

Background: Premature cardiac arrest (CA) is a major cause of death under 65. While declines in CA-related mortality have been observed, national, demographic, and regional trends for premature CA-related mortality remain unexplored. Aims: To evaluate national time trends and demographic and regional …

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Abstract 4363652: Contemporary Trends and Disparities in Premature Ischemic Stroke-Related Mortality in the United States, 1999–2022

Arindam Bagga, Fathima Shehnaz Ayoobkhan, Tarun Parvataneni, Wesam Aldosoky et autres

Background: Ischemic stroke, responsible for 87% of all strokes in the U.S., is a major cause of death and disability. Premature mortality from ischemic stroke, defined as death before age 65, leads to significant life year losses. However, national trends and disparities …

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Abstract 4365331: Muscle Matters: CT-Derived Skeletal Muscle Mass Is Independently Associated with Lower Cardiovascular Risk and Potentiates Exercise Benefit

Shady Abohashem, Wesam Aldosoky, Fatima Umaira Saeed, Krystel AbiKaram et autres

Background: Diminished skeletal muscle mass predicts frailty and mortality, yet its independent association with major adverse cardiovascular events (MACE) and its interplay with physical activity remain poorly defined. Clarifying these relationships may refine risk stratification beyond effects of adiposity, lifestyle, and genetic …

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Abstract 4365293: Nighttime Light Pollution Associates with Adverse Cardiovascular Events via a Mechanism Involving Heightened Stress-Related Neural Activity and Atherosclerotic Inflammation

Fatima Umaira Saeed, Wesam Aldosoky, Hannah Kim, Taha Z. Ahmad et autres

Background: Artificial light at night (ALAN) is ubiquitous in modern cities and linked to cardiometabolic disorders, yet its independent contribution to cardiovascular disease (CVD) remains uncertain. Stress-related neural-arterial pathways link socioenvironmental stressors to CVD, but their role in the ALAN-CVD relationship is …

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Abstract 4373384: Suboptimal Sleep Associates with Heightened Stress-Related Neurobiological and Leukopoietic Activity: Mediating Pathways to Cardiovascular Disease in Humans

Shady Abohashem, Wesam Aldosoky, Simran Grewal, Taimur A. Abbasi et autres

Background: Suboptimal sleep (Sleep SO )—due to insufficient duration or sleep disorders—is prevalent and linked to cardiovascular disease (CVD) risk. Experimental data suggest a stress-driven neural-immune axis linking poor sleep to atherogenesis, but the mechanisms in humans remain uncertain. Hypotheses: 1) Sleep …

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Abstract 4368787: The Role of Accelerated Development of Cardiovascular Disease Risk Factors in the Association between High Noise Exposure and Cardiovascular Events

Fatima Umaira Saeed, Krystel AbiKaram, Giovanni Civieri, Shady Abohashem et autres

Background: Noise exposure is a risk factor for the development of cardiovascular disease risk factors (CVDRFs, i.e., diabetes, hypertension, and hyperlipidemia) and major adverse cardiovascular events (MACE). Yet, it is not known how the development of CVDRFs contributes to the association between …

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Abstract 4365910: Depression and anxiety increase risk of chronic kidney disease via gain of CVD risk factors with an accentuated effect among women and non-white individuals

Krystel AbiKaram, Fatima Umaira Saeed, Shady Abohashem, Hui Chong Lau et autres

Background: Anxiety and depression accelerate the development of both cardiovascular risk factors and renal disease. It has been previously shown that CVD, its risk factors, and mental health disorders differ by sex and race. However, the influence of sex and race differences …

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Abstract 4360783: Accentuated Effect of Transportation Noise Exposure on Cardiovascular Risk in Individuals with Anxiety and Depression

Fatima Umaira Saeed, Shady Abohashem, Krystel AbiKaram, Alula Assefa et autres

Background: Stress-related psychiatric conditions (e.g., anxiety, depression) independently increase cardiovascular disease (CVD) risk. This association is mediated by neural-immune mechanisms, including stress-related neural activity (SNA), altered autonomic activity, and heightened systemic inflammation. Chronic exposure to transportation noise also associates with an increased …

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Hepatic steatosis associates with leukopoietic activity and atherosclerotic inflammation: mechanistic insights into cardiovascular risk

Shady Abohashem, Wesam Aldosoky, Taimur A. Abbasi, Tawseef Ahmad Dar et autres

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