Martin Rowland

3D printing of dose-flexible crystalline solid dispersion tablets suitable for preclinical and first-in-human studies

Garba M. Khalid, Carlos Bendicho‐Lavilla, AJ Worsley, Gary Haggan et autres

Traditional extemporaneous compounding methods of solid oral dosage forms required in early-stage studies are laborious, and the drug's solid state may affect the biopharmaceutical performance of the medicine. Maintaining the intended drug form in all stages of drug product development is critical. …

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Quality by digital design to accelerate sustainable medicines development

Chantal L. Mustoe, Alice Turner, Stephanie J. Urwin, Ian Houson et autres

We present a shared industry-academic perspective on the principles and opportunities for Quality by Digital Design (QbDD) as a framework to accelerate medicines development and enable regulatory innovation for new medicines approvals. This approach exploits emerging capabilities in industrial digital technologies to …

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Corrigendum to “Mechanistic modeling of twin screw wet granulation for pharmaceutical formulations: Calibration, sensitivity analysis, and model-driven workflow” [Int. J. Pharm. 659 (2024) 124246]

Neeru Bala, Jeremiah Corrigan, Bilal Ahmed, Jonathan Meyer et autres

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Mechanistic modeling of twin screw wet granulation for pharmaceutical formulations: Calibration, sensitivity analysis, and model-driven workflow

Neeru Bala, Jeremiah Corrigan, Jonathan Meyer, Marek Schöngut et autres

Wet granulation, a particle size enlargement process, can significantly enhance the critical quality attributes of powders and improve the ability to form tablets in pharmaceutical manufacturing. In this study, a mechanistic-based population balance model is applied to twin screw wet granulation. This …

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T-shaped partial least squares for high-dosed new active pharmaceutical ingredients in continuous twin-screw wet granulation: Granule size prediction with limited material information

Kensaku Matsunami, Jonathan Meyer, Martin Rowland, Neil Dawson et autres

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Releasing fast and slow: Non-destructive prediction of density and drug release from SLS 3D printed tablets using NIR spectroscopy

Sarah J. Trenfield, Xiaoyan Xu, Álvaro Goyanes, Martin Rowland et autres

Selective laser sintering (SLS) 3D printing is a revolutionary 3D printing technology that has been found capable of creating drug products with varied release profiles by changing the laser scanning speed. Here, SLS 3D printed formulations (printlets) loaded with a narrow therapeutic …

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How academic supervision can help optimise your studies

Martin Rowland

Discussing your work with an academic can help with assignments, as well as providing practical support on referencing and research

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Prediction of Solid-State Form of SLS 3D Printed Medicines Using NIR and Raman Spectroscopy

Sarah J. Trenfield, Patricija Januskaite, Álvaro Goyanes, David Wilsdon et autres

Selective laser sintering (SLS) 3D printing is capable of revolutionising pharmaceutical manufacturing, by producing amorphous solid dispersions in a one-step manufacturing process. Here, 3D-printed formulations loaded with a model BCS class II drug (20% w/w itraconazole) and three grades of hydroxypropyl cellulose …

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3D Printing of Tunable Zero-Order Release Printlets

Fabrizio Fina, Álvaro Goyanes, Martin Rowland, Simon Gaisford et autres

Zero-order release formulations are designed to release a drug at a constant rate over a prolonged time, thus reducing systemic side effects and improving patience adherence to the therapy. Such formulations are traditionally complex to manufacture, requiring multiple steps. In this work, …

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Non-destructive dose verification of two drugs within 3D printed polyprintlets

Sarah J. Trenfield, Hui Xian Tan, Álvaro Goyanes, David Wilsdon et autres

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Measuring The Bipolar Charge Distributions of Fine Particle Aerosol Clouds of Commercial PMDI Suspensions Using a Bipolar Next Generation Impactor (bp-NGI)

Martin Rowland, Alessandro Cavecchi, Frank Thielmann, Janusz Kulon et autres

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3D printed drug products: Non-destructive dose verification using a rapid point-and-shoot approach

Sarah J. Trenfield, Álvaro Goyanes, Richard Telford, David Wilsdon et autres

Three-dimensional printing (3DP) has the potential to cause a paradigm shift in the manufacture of pharmaceuticals, enabling personalised medicines to be produced on-demand. To facilitate integration into healthcare, non-destructive characterisation techniques are required to ensure final product quality. Here, the use of …

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