Matty Zimmerman

Executive Summary: State-of-the-Art Review: Hepatitis C

Vincent Lo Re, Debika Bhattacharya, Jennifer C. Price, Andrew Aronsohn et autres

Hepatitis C virus (HCV) infection remains a major cause of chronic liver disease and premature mortality worldwide. The World Health Organization and US Department of Health and Human Services have committed to eliminate HCV infection as a major public health threat by …

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State-of-the-Art Review: Hepatitis C

Vincent Lo Re, Debika Bhattacharya, Jennifer C. Price, Andrew Aronsohn et autres

Hepatitis C virus (HCV) infection remains a major cause of chronic liver disease and premature mortality worldwide. The World Health Organization and US Department of Health and Human Services have committed to eliminating HCV infection as a major public health threat by …

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Expanding Treatment Opportunities: Reviewing the Current State of Injectable Antiretrovirals for Treatment of HIV

Amanda Binkley, Matty Zimmerman, Christina Maguire

Antiretroviral therapy has evolved significantly over the last 20-30 years, from requiring multiple tablets multiple times per day to single-tablet regimens and most recently, in 2021, long-acting injectable antiretrovirals. These long-acting antiretrovirals have expanded the treatment options for individuals with HIV who …

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Safety Data Timelines for Pregnant Individuals With HIV on Antiretroviral Therapy

William R. Short, Matty Zimmerman, Ola Mohamed, Lynne Mofenson

Antiretrovirals are often approved by the Food and Drug Administration without sufficient safety data regarding their use in pregnancy. To quantify this delay, we calculated the interval from the approval date to their inclusion in the Antiretroviral Pregnancy Registry prospective analysis (≥200 …

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1716. Outcomes and adverse effects of risk-based perinatal antiretroviral regimens to prevent HIV transmission: A real-world experience

Matty Zimmerman, Alice J. Hsu, Bethany Chalk, Caroline Liang et autres

Abstract Background Annually ∼5,000 women living with HIV give birth in the US. US Public Health Guidelines recommend that perinatally-exposed infants receive antiretrovirals (ARV) to reduce transmission risk. Low risk infants receive 1 ARV (zidovudine, AZT) for 4 weeks, while highest risk …

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Identifying Effective Durations of Antibiotic Therapy for the Treatment of Carbapenem-resistant Enterobacterales Bloodstream Infections: A Multicenter Observational Study

Caitlin Soto, Alice J. Hsu, Jae Hyoung Lee, Kathryn Dzintars et autres

In a propensity-score-weighted cohort of 183 adults with carbapenem-resistant Enterobacterales bacteremia at 24 US hospitals, patients receiving short courses of active therapy (7-10 days, median 9 days) experienced similar odds of recurrent bacteremia or death within 30 days as those receiving prolonged …

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Infectious Diseases Consultation Associated With Reduced Mortality in Gram-Negative Bacteremia

Stephanie Shulder, Pranita D. Tamma, Suiyini Fiawoo, Kathryn Dzintars et autres

Gram-negative bacteremia (GN-BSI) can cause significant morbidity and mortality, but the benefit of infectious diseases consultation (IDC) is not well defined. A 24-site observational cohort study of unique hospitalized patients with 4861 GN-BSI episodes demonstrated a 40% decreased risk of 30-day mortality …

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Weight changes in patients with sustained viral suppression switching tenofovir disoproxil fumarate to tenofovir alafenamide

Jason J. Schafer, Matty Zimmerman, Ciara Walshe, Jesse Cerankowski et autres

OBJECTIVE: Switching from tenofovir disoproxil fumarate (TDF)- to tenofovir alafenamide (TAF)-containing antiretroviral therapy may negatively influence weight, cholesterol, and atherosclerotic cardiovascular disease risk. The extent of these changes and their association with TAF remain unclear. METHODS: This retrospective cohort evaluated metabolic changes …

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828. Short- and Long-Term Metabolic Changes in Virologically Suppressed Patients Switching from TDF to TAF Containing Antiretroviral Therapy

Jason J. Schafer, Matty Zimmerman, Ciara Walshe, Jessie Cerankowski et autres

Abstract Background Switching from tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide (TAF) containing antiretroviral therapy (ART) may negatively influence weight, cholesterol, and atherosclerotic cardiovascular disease (ASCVD) risk. The timing, duration, and extent of these changes and their definitive associations with TAF remain …

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Cognitive rigidity and BDNF-mediated frontostriatal glutamate neuroadaptations during spontaneous nicotine withdrawal

Robert D. Cole, Matty Zimmerman, Anastasia Matchanova, Munir Gunes Kutlu et autres

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332. Exploring the Prevalence and Characteristics of Weight Gain and other Metabolic Changes in Patients with HIV Infection Switching to Integrase Inhibitor Containing ART

Matty Zimmerman, Joseph DeSimone, Jason J. Schafer

Abstract Background Excessive weight gain in patients living with HIV (PLWH) can have considerable health-related consequences. Recent observational studies suggest that patients initiating or switching to integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) may experience weight gain. The prevalence and extent …

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Weight Gain in Patients with HIV Infection who are Virologically Suppressed on Antiretroviral Therapy and Switch to Integrase Inhibitor Containing Regimens

Matty Zimmerman, PharmD Schafer

Objective To determine the prevalence and extent of weight gain among virologically suppressed PLWH whose antiretroviral therapy (ART) has been switched to an integrase inhibitor (INSTI) containing regimen.