Lada A. Koneva

Autophagy acts as a brake on obesity-related fibrosis by controlling purine nucleoside signalling

Klara Piletič, Amir Hossein Kayvanjoo, Felix Clemens Richter, Mariana Borsa et autres

A hallmark of obesity is a pathological expansion of white adipose tissue (WAT), accompanied by marked tissue dysfunction and fibrosis. Autophagy promotes adipocyte differentiation and lipid homeostasis, but its role in obese adipocytes and adipose tissue dysfunction remains incompletely understood. Using a …

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Mechano-activated chondroprogenitors (MACs) drive intrinsic cartilage repair; a process that is arrested in osteoarthritis

Linyi Zhu, Hayat Muhammad, Thomas A. Perry, Anastasia Ardasheva et autres

Abstract Articular cartilage, an avascular, matrix-rich tissue, is thought to have limited repair, thereby contributing to osteoarthritis (OA), the common degenerative disease of joints. Cartilage regeneration does occur, however, in OA joints that are mechanically off-loaded. Here we show that mechanical stress, …

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ABS0240 MECHANO-ACTIVATED CHONDROPROGENITORS (MACS) DERIVED FROM ARTICULAR CHONDROCYTES, WHICH DRIVE INTRINSIC CARTILAGE REPAIR

Linyi Zhu, H. Muhammad, Taylor A Perry, Rebecca A Symons et autres

Background: Osteoarthritis (OA) is a highly prevalent, age-associated disease, for which no disease-modifying treatments currently exist. The degradation of articular cartilage, a low-cellularity, avascular tissue with limited regenerative capacity, is the hallmark of OA. Cartilage is highly mechanosensitive, and one mechanism of …

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Autophagy acts as a brake on obesity-related fibrosis by controlling purine nucleoside signalling

Klara Piletič, Amir Hossein Kayvanjoo, Felix Clemens Richter, Mariana Borsa et autres

ABSTRACT A hallmark of obesity is a pathological expansion of white adipose tissue (WAT), accompanied by marked tissue dysfunction and fibrosis. Autophagy promotes adipocyte differentiation and lipid homeostasis, but its role in obese adipocytes and adipose tissue dysfunction remains incompletely understood. Here, …

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Unravelling the phenotype of surviving chondrocytes after cartilage injury

Linyi Zhu, Lada A. Koneva, Stephen N. Sansom, Jana Riegger et autres

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Author Correction: Lipid-associated macrophages transition to an inflammatory state in human atherosclerosis, increasing the risk of cerebrovascular complications

Lea Dib, Lada A. Koneva, Andreas Edsfeldt, Yasemin-Xiomara Zurke et autres

Correction to: Nature Cardiovascular Research https://doi.org/10.1038/s44161-023-00295-x . Published online 26 June 2023.

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Publisher Correction: Lipid-associated macrophages transition to an inflammatory state in human atherosclerosis, increasing the risk of cerebrovascular complications

Lea Dib, Lada A. Koneva, Andreas Edsfeldt, Yasemin-Xiomara Zurke et autres

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Lipid-associated macrophages transition to an inflammatory state in human atherosclerosis, increasing the risk of cerebrovascular complications

Lea Dib, Lada A. Koneva, Andreas Edsfeldt, Yasemin-Xiomara Zurke et autres

Abstract The immune system is integral to cardiovascular health and disease. Targeting inflammation ameliorates adverse cardiovascular outcomes. Atherosclerosis, a major underlying cause of cardiovascular disease, is conceptualized as lipid-driven inflammation in which macrophages play a nonredundant role. However, evidence emerging so far …

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Table S3 from HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers

Lada A. Koneva, Yanxiao Zhang, Shama Virani, Pelle B. Hall et autres

Network statistics for network constructed from 89 genes with/near integration events.

Data from HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers

Lada A. Koneva, Yanxiao Zhang, Shama Virani, Pelle B. Hall et autres

Abstract The incidence of human papillomavirus (HPV)–related oropharynx cancer has steadily increased over the past two decades and now represents a majority of oropharyngeal cancer cases. Integration of the HPV genome into the host genome is a common event during carcinogenesis that …

Supplemental Materials and Methods; Supplementary Tables 5-14; Supplementary Figures 1-3. from HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers

Lada A. Koneva, Yanxiao Zhang, Shama Virani, Pelle B. Hall et autres

Supplemental Methods, Tables S5-S14, and Figures S1-S3

Table S4 from HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers

Lada A. Koneva, Yanxiao Zhang, Shama Virani, Pelle B. Hall et autres

GO terms and KEGG pathways enriched for genes differentially expressed between integration-positive and integration-negative HNC tumors.