Frank Wolters

Association between thyroid function with migraine and stroke risk: the rotterdam study

Xiaoyi Qi, Frank Wolters, Robin Peeters, Layal Chaker

ABSTRACT NUMBER: ESOC2026A1120 DISENTANGLING PROGNOSTIC HETEROGENEITY IN VASCULAR COGNITIVE IMPAIRMENT: A BAYESIAN NETWORK ANALYSIS

Malin Overmars, Cor Allaart, E Bron Esther, Jeroen de Bresser et autres

Abstract Background and aims Vascular cognitive impairment (VCI) is a heterogeneous construct with variable risk factors, pathologies, and outcomes. This heterogeneity combined with attrition bias complicates prognostic modeling. Here, we demonstrate how a Bayesian network (BN) can jointly model interdependencies for future …

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ABSTRACT NUMBER: ESOC2026A183 ASYMPTOMATIC CAROTID ARTERY STENOSIS, COGNITIVE DECLINE AND DEMENTIA: A PROSPECTIVE POPULATION-BASED COHORT STUDY

Camiel Box, Amos Pomp, Maryam Kavousi, M. Kamran Ikram et autres

Abstract Background and aims Asymptomatic carotid artery stenosis (ACAS) increases the risk of stroke, but it is uncertain whether individuals with >50% stenosis benefit from endovascular or surgical intervention. Additional benefit of carotid revascularisation on cognition may tilt the balance in favour …

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The role of bile salts in itch receptor activation

Frank Wolters, Dagmar Tolenaars, Michel van Weeghel, Dirk de Waart et autres

BACKGROUND: Cholestasis-associated pruritus is a distressing symptom. Bile salts and bilirubin are often implicated in the etiology of pruritus. We evaluated whether these compounds activate known itch receptors. METHODS: . TGR5 activation was assayed by means of cAMP ELISA in TGR5 overexpressing …

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SAT-160 Lysophosphatidic acid (LPA)-receptors, a group of established itch receptors, show elevated agonism during cholestasis and are likely to contribute to cholestasis-associated itch

Frank Wolters, Dagmar Tolenaars, Michel van Weeghel, Rudi D. de Waart et autres

PPARα, PPARδ, or both—that is the question!

Frank Wolters, Ronald P.J. Oude Elferink, Ulrich H. Beuers

Cholestatic pruritus may affect 2 out of 3 individuals with, for example, primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), the most common chronic cholestatic liver diseases.1 Cholestatic pruritus shows a diurnal variation with peak intensity early at night and may …

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The role of bile salts in cholestasis associated pruritus

Frank Wolters, Dagmar Tolenaars, Rudi D. de Waart, Arthur J. Verhoeven et autres

Mechanisms of pruritus in cholestasis: understanding and treating the itch

Ulrich H. Beuers, Frank Wolters, Ronald P.J. Oude Elferink

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Systemic ASBT inactivation protects against liver damage in obstructive cholestasis in mice

Roni F. Kunst, Dirk Rudi de Waart, Frank Wolters, Suzanne Duijst et autres

Background & Aims: Non-absorbable inhibitors of the apical sodium-dependent bile acid transporter (ASBT; also called ileal bile acid transporter [IBAT]) are recently approved or in clinical development for multiple cholestatic liver disorders and lead to a reduction in pruritus and (markers for) …

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