Tingping Zhu

Exploring China’s Clean Air Act and associated cardiovascular disease risk: a prospective, quasi-experimental, and causal inference modelling study

Dong Sun, Xia Meng, Jingcen Hu, Canqing Yu et autres

BACKGROUND: Substantial improvements in air quality have been recorded following the implementation of China's Clean Air Act (CCAA) in 2013. However, the association between CCAA implementation and individual-level cardiovascular disease (CVD) risk remains unclear. We aimed to examine the long-term association between …

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Body Roundness Index, MASLD risk and long-term follow-up outcomes among the general population

Huai Zhang, Li-You Lian, Airong Lv, Tianyi Xia et autres

BACKGROUND & AIMS: This study aimed to examine the associations of the body roundness index (BRI) with metabolic dysfunction-associated steatotic liver disease (MASLD), and long-term mortality outcomes, given that the body mass index (BMI) does not adequately reflect visceral adiposity. METHODS: Three …

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Genetic Associations With Carotid Intima-Media Thickness in the Chinese Population and Shared Genetic Architecture With Cardiometabolic Diseases and Traits

Wenxiu Wang, Ninghao Huang, Canqing Yu, Dianjianyi Sun et autres

BACKGROUND: Carotid artery intima-media thickness (cIMT) is a highly heritable measure of subclinical atherosclerosis and a predictor of cardiovascular diseases. However, knowledge about its shared genetic basis remains limited. The majority of genome-wide association studies have been conducted in individuals of European …

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Associations of 6600 SomaScan proteins with demographic, lifestyle, environmental and health characteristics in Chinese adults

Ka Hung Chan, Jonathan Clarke, Maria G. Kakkoura, Andri Iona et autres

AKR1D1: 3-Oxo-5-beta-steroid 4-dehydrogenase ALT: Alanine aminotransferase ANML: Adaptive normalisation by maximum likelihood ANTR2: Anthrax toxin receptor 2 APOF: Apolipoprotein F BGN: Biglycan BMI: Body mass index BPSA: Benign prostatic-specific antigen C1QTNF1: C1q and tumor necrosis factor related protein 1 C1QTNF3: C1q and …

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Young adulthood adiposity in relation to all-cause and cause-specific mortality: a prospective study of 0.5 million Chinese adults

Lei Fan, Andri Iona, Shixian Feng, Gang Zhou et autres

Obesity is a well-established risk factor for early death, but the exact shapes of associations between young adulthood body mass index (BMI) and mortality in later life were not well characterised. Using data from the prospective China Kadoorie Biobank study of 430,373 …

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The COPD risk associated with adulthood weight change and early adulthood BMI: a prospective cohort study

Lu Chen, Wei Yu, Dianjianyi Sun, Pei Pei et autres

BACKGROUND: Gaps concerning general adiposity and chronic obstructive pulmonary disease (COPD) are delaying policies for weight interventions in COPD prevention, especially adiposity in early adulthood and weight changes during adulthood. METHODS: Based on the China Kadoorie Biobank, a prospective cohort between 2004–2008 …

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Expanded mosaic chromosomal alterations, frailty, and risks of all-cause and cause-specific mortality among Chinese and the UK adults: evidence from two prospective cohorts

Mingyu Song, Zilun Shao, Yuting Han, Yuxuan Zhao et autres

BACKGROUND: Mosaic chromosomal alterations (mCAs) served as a novel indicator of genomic aging. We aimed to investigate the association of expanded mCAs (cell fraction ≥ 10%) with all-cause and cause-specific mortality, and to examine the joint effect of expanded mCAs and frailty …

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A simulation study of the impact of population-wide lifestyle modifications on life expectancy in the Chinese population

Qiufen Sun, Liyun Zhao, Yuxiang Yang, Yinqi Ding et autres

It is uncertain how much life expectancy of the Chinese population would improve under current and greater policy targets on lifestyle-based risk factors for chronic diseases and mortality. Here we report a simulation of how improvements in four risk factors, namely smoking, …

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Predictive value of 8-year blood pressure measures in intracerebral haemorrhage risk over 5 years

Yiqian Zhang, Yinqi Ding, Canqing Yu, Dianjianyi Sun et autres

AIMS: The relationships between long-term blood pressure (BP) measures and intracerebral haemorrhage (ICH), as well as their predictive ability on ICH, are unclear. In this study, we aim to investigate the independent associations of multiple BP measures with subsequent 5-year ICH risk, …

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Secondhand smoke exposure can increase the risk of first ischemic stroke: A 10.7-year prospective cohort study in China

Rumei Lu, Yulu Qin, Changping Xie, Xiaoping Tan et autres

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Spicy food consumption reduces the risk of ischaemic stroke: a prospective study

Jiale Li, Changping Xie, Jian Lan, Jinxue Tan et autres

Previous studies revealed that consuming spicy food reduced mortality from CVD and lowered stroke risk. However, no studies reported the relationship between spicy food consumption, stroke types and dose–response. This study aimed to further explore the association between the frequency of spicy …

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Causal association between snoring and stroke: a Mendelian randomization study in a Chinese population

Yunqing Zhu, Zhenhuang Zhuang, Jun Lv, Dianjianyi Sun et autres

Background Previous observational studies established a positive relationship between snoring and stroke. We aimed to investigate the causal effect of snoring on stroke. Methods Based on 82,339 unrelated individuals with qualified genotyping data of Asian descent from the China Kadoorie Biobank (CKB), …

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