Jian Lan

Proteomic organ-specific signatures, ageing traits, disease risks and genetic architecture in an East Asian population

Derrick Bennett, Baihan Wang, Sihao Xiao, Neil Wright et autres

BACKGROUND: Protein-based ageing clocks can be used to help identify individuals at high risk of death or morbidity. There is a lack of evidence in non-European populations on clocks derived from combining different proteomic platforms and their relationship with age-related traits, diseases …

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Associations of 6600 SomaScan proteins with demographic, lifestyle, environmental and health characteristics in Chinese adults

Ka Hung Chan, Jonathan Clarke, Maria G. Kakkoura, Andri Iona et autres

AKR1D1: 3-Oxo-5-beta-steroid 4-dehydrogenase ALT: Alanine aminotransferase ANML: Adaptive normalisation by maximum likelihood ANTR2: Anthrax toxin receptor 2 APOF: Apolipoprotein F BGN: Biglycan BMI: Body mass index BPSA: Benign prostatic-specific antigen C1QTNF1: C1q and tumor necrosis factor related protein 1 C1QTNF3: C1q and …

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PM2.5 exposure exacerbates airway pyroptosis related inflammatory response in asthmatic mice by activating NLRP3 inflammasome

Hui Du, Zhi Liu, Lixin Ge, Yuxi Lei et autres

cn (code pays fourni par la source)

The COPD risk associated with adulthood weight change and early adulthood BMI: a prospective cohort study

Lu Chen, Wei Yu, Dianjianyi Sun, Pei Pei et autres

BACKGROUND: Gaps concerning general adiposity and chronic obstructive pulmonary disease (COPD) are delaying policies for weight interventions in COPD prevention, especially adiposity in early adulthood and weight changes during adulthood. METHODS: Based on the China Kadoorie Biobank, a prospective cohort between 2004–2008 …

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A simulation study of the impact of population-wide lifestyle modifications on life expectancy in the Chinese population

Qiufen Sun, Liyun Zhao, Yuxiang Yang, Yinqi Ding et autres

It is uncertain how much life expectancy of the Chinese population would improve under current and greater policy targets on lifestyle-based risk factors for chronic diseases and mortality. Here we report a simulation of how improvements in four risk factors, namely smoking, …

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Predictive value of 8-year blood pressure measures in intracerebral haemorrhage risk over 5 years

Yiqian Zhang, Yinqi Ding, Canqing Yu, Dianjianyi Sun et autres

AIMS: The relationships between long-term blood pressure (BP) measures and intracerebral haemorrhage (ICH), as well as their predictive ability on ICH, are unclear. In this study, we aim to investigate the independent associations of multiple BP measures with subsequent 5-year ICH risk, …

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Secondhand smoke exposure can increase the risk of first ischemic stroke: A 10.7-year prospective cohort study in China

Rumei Lu, Yulu Qin, Changping Xie, Xiaoping Tan et autres

cn (code pays fourni par la source)

Association between health insurance cost-sharing and choice of hospital tier for cardiovascular diseases in China: a prospective cohort study

Muriel Levy, John Buckell, Robert Clarke, Nina Wu et autres

Background: Hospitals in China are classified into tiers (1, 2 or 3), with the largest (tier 3) having more equipment and specialist staff. Differential health insurance cost-sharing by hospital tier (lower deductibles and higher reimbursement rates in lower tiers) was introduced to …

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Spicy food consumption reduces the risk of ischaemic stroke: a prospective study

Jiale Li, Changping Xie, Jian Lan, Jinxue Tan et autres

Previous studies revealed that consuming spicy food reduced mortality from CVD and lowered stroke risk. However, no studies reported the relationship between spicy food consumption, stroke types and dose–response. This study aimed to further explore the association between the frequency of spicy …

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Causal association between snoring and stroke: a Mendelian randomization study in a Chinese population

Yunqing Zhu, Zhenhuang Zhuang, Jun Lv, Dianjianyi Sun et autres

Background Previous observational studies established a positive relationship between snoring and stroke. We aimed to investigate the causal effect of snoring on stroke. Methods Based on 82,339 unrelated individuals with qualified genotyping data of Asian descent from the China Kadoorie Biobank (CKB), …

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PCSK9 genetic variants and risk of vascular and non-vascular diseases in Chinese and UK populations

Michael V. Holmes, Christiana Kartsonaki, Ruth Boxall, Kuang Lin et autres

AIMS: Lowering low-density lipoprotein cholesterol (LDL-C) through PCSK9 inhibition represents a new therapeutic approach to preventing and treating cardiovascular disease (CVD). Phenome-wide analyses of PCSK9 genetic variants in large biobanks can help to identify unexpected effects of PCSK9 inhibition. METHODS AND RESULTS: …

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Plasma Proteomics to Identify Drug Targets for Ischemic Heart Disease

Mohsen Mazidi, Neil Wright, Pang Yao, Christiana Kartsonaki et autres

BACKGROUND: Integrated analyses of plasma proteomic and genetic markers in prospective studies can clarify the causal relevance of proteins and discover novel targets for ischemic heart disease (IHD) and other diseases. OBJECTIVES: The purpose of this study was to examine associations of …

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