Zhenao Zhang

Urban heat island and risk of rheumatoid arthritis: Insights from genetic predisposition and proteomics

Zhenao Zhang, Gao ShunBing, Xue Hu, Xiaoya Sun et autres

cn (code pays fourni par la source)

Independent and interactive effects of personal light exposure and air pollution on incident COPD: A prospective cohort study with 13 million hours of light sensor data

Zhenao Zhang, Xiaoya Sun, J Y Ren, Zi Wang et autres

cn (code pays fourni par la source)

EAT‐Lancet Diet, Plasma Metabolites, and Risk of Peripheral Artery Disease: A Prospective Cohort Study

Zhenao Zhang, J Y Ren, Xiaoya Sun, Siqi Zhu et autres

BACKGROUND: The Planetary Health Diet Index, developed by the EAT-Lancet Commission, promotes sustainable and healthy eating, yet its association with peripheral artery disease (PAD) remains underexplored. Furthermore, the metabolic mechanisms potentially linking this dietary pattern to PAD warrant deeper investigation. METHODS: In …

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Wearable device-measured sedentary behaviour, physical activity, and incident symptomatic peripheral artery disease: a prospective cohort study of 87,490 adults

Xiaolong Zhang, Xiaoya Sun, Xiwang Mao, Chongyue Zhang et autres

cn (code pays fourni par la source)

Association between urban heat island and type 2 diabetes risk: genetic and proteomic insights

Jingyi Ren, Xiaoya Sun, Zhenao Zhang, Xiaolong Zhang et autres

BACKGROUND: The urban heat island (UHI) effect is increasingly recognized as an environmental risk factor for human health, yet its association with type 2 diabetes (T2D) and underlying mechanisms remain poorly understood. This study investigated the impact of summer UHI exposure on …

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Baseline body mass index modifies the effects of digital health interventions compared with usual care on cardiovascular disease risk in people with type 2 diabetes: a secondary analysis of the SMARTDiabetes trial

Jingyi Ren, Xiaoya Sun, Zhenao Zhang, Yadong Zhang et autres

cn, au (code pays fourni par la source)

Protective Effects of Astaxanthin on PFOS-Induced Liver Injury via Fatty Acid and Cholesterol Metabolic Pathways

Bowen Yin, Xuanyi Liu, Miaomiao Lu, Siqi Zhu et autres

Perfluorooctanesulfonate (PFOS) is a persistent bioaccumulative pollutant that can induce significant liver injury and functional impairment. Astaxanthin (ASX) is a naturally occurring carotenoid with potent bioactive properties and hepatoprotective effects. However, whether ASX can mitigate PFOS-induced liver injury and its underlying molecular …

cn, us (code pays fourni par la source)

Sesamin Protects Against Polystyrene Microplastics-Induced Lung Injury via Attenuating Bcl2-Mediated Apoptosis

Yadong Zhang, Zhenao Zhang, Huanting Pei, Chongyue Zhang et autres

Studies show microplastics (MPs) impair lung function directly and indirectly, yet effective solutions are lacking. In light of this, sesamin (Ses), a natural lignan-like compound with diverse pharmacological properties, may offer protection. The study aims to investigate whether Ses pretreatment can mitigate …

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Association of Fish Consumption, Dietary Omega‐3 Polyunsaturated Fatty Acids With Phenotypic Age Acceleration in Adults After Considering Blood Cadmium Levels

Xiaoya Sun, Jingyi Ren, Zhenao Zhang, Huanting Pei et autres

Fish is rich in nutrients; however, concerns persist regarding its potential role in delaying aging due to the possible accumulation of cadmium. This study aimed to assess the association between fish consumption, dietary ω-3 polyunsaturated fatty acids (PUFAs), and Phenotypic Age Acceleration …

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Sesamin alleviates drug-induced hepatotoxicity via autophagy enhancement and ferroptosis inhibition

Jingyi Ren, Ziyi Wang, Yadong Zhang, Huanting Pei et autres

Background: Acetaminophen (APAP) overdose is the leading cause of drug-induced acute liver failure. Sesamin (Ses), a natural polyphenolic compound, possesses diverse pharmacological properties. This study was to explore the effects of Ses on APAP-induced liver injury and the underlying molecular mechanism.Methods: In …

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Sesamin attenuates liver inflammation caused by PFOS via regulating SAP130-mediated hepatocyte-macrophage crosstalk

Jingyi Ren, Longfei Li, Ziyi Wang, Siqi Zhu et autres

BACKGROUND: Perfluorooctane sulfonate (PFOS) is a prototypical persistent organic pollutant that has been linked to liver inflammation. Sesamin (Ses), a major lignan in sesame, has been shown to exhibit health-promoting properties. However, the role and specific mechanism of Ses in PFOS-induced liver …

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Sesamin protects against Acetaminophen-induced nephrotoxicity by suppressing HMOX1-mediated apoptosis and ferroptosis

Siqi Zhu, Jingyi Ren, Yadong Zhang, Xiaoya Sun et autres

BACKGROUND: Acetaminophen (APAP) is a widely used antipyretic and analgesic agent, and acute exposure can lead to renal injury. Sesamin (Ses) is known for its various health benefits. However, it remains unclear whether Ses exerts a protective effect against APAP-induced kidney injury. …

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