Iryna Yu. Avramenko

The clinical manifestation and diagnostic features of Kawasaki-like phenotypes in pediatric multisystem inflammatory syndrome: a comparative retrospective study in Ukraine

Nataliia Bodnarchuk-Sokhatska, Halyna Pavlyshyn, Kateryna Kozak, Iryna Yu. Avramenko

Background: The clinical overlap syndrome between multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease (KD), particularly in the context of SARS-CoV-2 infection, presents diagnostic challenges. The presence of both complete and incomplete Kawasaki-like phenotypes (KLP) further complicates differentiation. This study aimed …

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CLINICAL CASE OF RARE SMITH-MAGENIS SYNDROME IN NEWBORN CHILD

H.S. Chaykovska, M. Drobchak, Hayane Akopyan, Iryna Yu. Avramenko et autres

Aim. The purpose of the work is a comprehensive analysis of chromosomal pathology based on own detection of a rare clinical case of Smith-Magenis syndrome in a newborn child, the results of which may be useful for the detection and prevention of …

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Potential role of vitamins B (B6, B9, B12) in the severity of COVID-19 in children

Halyna Pavlyshyn, О. В. Лабівка, Kateryna KOZAK, Olha Dyvonyak et autres

BACKGROUND: The aim of this paper was to study the levels of vitamins B6, B9, B12 and homocysteine in children with COVID-19 and assess their variations based on the severity of the disease.METHODS: A total of 112 children were examined. The levels …

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The course of COVID-19 in school-aged children depends on the state of humoral immunity against diphtheria

Halyna Pavlyshyn, O. I. Panchenko, Kateryna Kozak, Iryna Yu. Avramenko et autres

Introduction: There is evidence that high titers of diphtheria antibodies are more often associated with an asymptomatic or less severe course of COVID-19. The aim of the study was to determine the features of the COVID-19 course in school-aged children depending on …

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Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection

Astrid Marchal, Elizabeth T. Cirulli, Iva Neveux, Evangelos Bellos et autres

Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between the HLA-B∗15:01 allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently reported, suggesting a contribution of …

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Assessment of the quality of life of children after cardiac surgery: researches and conclusions

N.S. Kosmynina, Iryna Yu. Avramenko

Studying the quality of life of patients, in particular children, is one of the important areas of modern medicine. Aim. To assess the quality of life of children who were operated on for congenital heart disease. Materials and methods. 100 children from …

SARS-CoV-2 infection and thyroid dysfunction in children

Kateryna Kozak, Halyna Pavlyshyn, Iryna Yu. Avramenko, O. M. Dyvonyak et autres

The problem of thyroid dysfunction related to SARS-CoV-2 infection remains unclear in children. Therefore, the study aimed to reveal the interrelationship between thyroid dysfunction and COVID-19 severity­ as well as to determine optimal cut-off values for screening for thyroid disorders in children. …

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Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Daniela Matuozzo, Estelle Talouarn, Astrid Marchal, Peng Zhang et autres

Abstract Background We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15–20% of cases of life-threatening COVID-19 in unvaccinated patients. …

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MORPHOMETRIC AND MORPHOLOGICAL ASSESSMENT OF CORONARY ARTERIES WITH INTRAVASCULAR ULTRASOUND

Uliana Pidvalna, Dmytro Beshley, Iryna Yu. Avramenko, Л. Р. Матешук-Вацеба

OBJECTIVE: The aim: To perform a morphometric assessment of the coronary arteries ostia by intravascular ultrasound with morphological evaluation among the Ukrainian population. PATIENTS AND METHODS: Materials and methods: Intravascular images of the ostia of the right (48%) and left (52%) coronary …

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Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children

Danyel Lee, Jérémie Le Pen, Ahmad Yatim, Beihua Dong et autres

Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that follows benign COVID-19. We report autosomal recessive deficiencies of OAS1 , OAS2 , or RNASEL in five unrelated children with MIS-C. The cytosolic double-stranded RNA (dsRNA)–sensing OAS1 and OAS2 …

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COVID-19 in children: multisystem inflammatory syndrome

Iryna Yu. Avramenko, N.S. Kosmynina, М.В. Стасів, В.Р. Міщук

Unlike adults, children are less likely to get infected SARS-CoV-2, their disease has a mild form and fatal cases are rather rare. However, a new disease associated with SARS-CoV-2, the multisystem inflammatory syndrome (MIS-C), has been described in children. Most children with …

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The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

Jérémy Manry, Paul Bastard, Adrian Gervais, Tom Le Voyer et autres

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing IFN-α, IFN-ω, and/or IFN-β are found in ∼20% of deceased patients across age groups, and in ∼1% of …

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