Accès ouvert
2025
article
OpenAlex
Nicolás Luis Calzetta, Sabrina F. Mansilla, Candelaria Mares Ahlers, Agostina P. Bertolin et autres
The rate of DNA synthesis is crucial for full DNA duplication. We report a key role of p21 in controlling this rate. During normal replication, p21 promotes nascent DNA synthesis alongside the DNA polymerase iota (Pol ι)/p53 complex. When p21 is down-regulated …
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Accès ouvert
2025
article
OpenAlex
Yiovana Verónica Okraine, María Belén de la Vega, Sofía Venerus Arbilla, Ginette Moyano et autres
Cancer cells that survive chemotherapy achieve full DNA duplication despite the accumulation of damaged DNA triggered by chemotherapy. This happens because the synthesis of DNA at damaged sites is granted by tolerance events including translesion DNA synthesis (TLS), a process that promotes …
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Accès ouvert
2023
article
OpenAlex
Sabrina F. Mansilla, Agostina P. Bertolin, Sofía Venerus Arbilla, Bryan A. Castaño et autres
Recent studies have described a DNA damage tolerance pathway choice that involves a competition between PrimPol-mediated repriming and fork reversal. Screening different translesion DNA synthesis (TLS) polymerases by the use of tools for their depletion, we identified a unique role of Pol …
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