B. Prendes

Molecular analysis of aggressive disease and treatment response in recurrent/metastatic head and neck squamous cell carcinoma.

Chana Peysin, Neil McIver Woody, Salendra Singh, Ying Ni et autres

e18033 Background: Immunotherapy (IO), alone or with chemotherapy, is standard first-line treatment for recurrent/metastatic head and neck squamous cell carcinoma (HNSCC). Here, we evaluated molecular features associated with disease patterns and treatment response in HNSCC. Methods: Molecular profiling data were retrospectively reviewed …

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Outcomes and factors associated with first line chemoimmunotherapy (ChemoIO) or immunotherapy (IO) in recurrent/metastatic head and neck squamous cell carcinoma (HNSCC).

Chana Peysin, Neil McIver Woody, Chandana A. Reddy, Jessica Lyn Geiger et autres

e18095 Background: IO alone or with chemotherapy, is standard first-line therapy for recurrent/metastatic HNSCC. This study investigates real-world outcomes and clinical factors associated with survival in patients (pts) receiving first-line chemoIO or IO alone. Methods: Pts with recurrent/metastatic HNSCC treated with first-line …

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Transoral Minimal Access Mandibular Reconstruction Using Fibula Free Flap in Osteoradionecrosis

Derek J. Vos, Emily Zhang, Neil N. Patel, Sara W. Liu et autres

OBJECTIVE: To describe the use, indications, and outcomes of a limited transoral approach for segmental mandibulectomy reconstruction with minimal access vessel isolation and anastomoses in patients with mandibular osteoradionecrosis. METHODS: Retrospective review of patients who have undergone FFF reconstruction of segmental mandibulectomy …

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ALT Rescue Flap With Iliac Crest Bone Graft and Spanning Plate for Mandibular ORN

Derek J. Vos, Sara W. Liu, Peter J. Ciolek, B. Prendes et autres

OBJECTIVE: The mainstay of treatment for full-thickness mandibular osteoradionecrosis (ORN) is segmental mandibulectomy followed by osteocutaneous free flap. We have found success in combining anterolateral thigh rescue flaps with iliac crest bone graft (ICBG) and spanning reconstructive plate for select patients. Our …

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Anterolateral‐Thigh Fascia Lata Free Flap Versus Fibula Free Flap for Mandibular Osteoradionecrosis

Conrad K. Blunck, Alexander Havens, Michael A. Fritz, B. Prendes et autres

OBJECTIVES: While standard treatments for mandibular osteoradionecrosis (MORN) exist for mild/superficial and severe/full thickness disease, there is no consensus on treatment for advanced, partial thickness disease. In this niche, the anterolateral thigh fascia lata (ALTFL) "rescue" flap has managed MORN successfully. This …

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Reimbursement for Thyroid Surgery and Potential Solutions

Philip R. Brauer, David Octeau, Benjamin Wajsberg, Eric Lamarre et autres

Importance: In 2024, the US Senate Committee on Finance released a white paper outlining future reforms to the Medicare payment models. Objective: To characterize trends in Medicare reimbursement for thyroid surgery and to provide evidence for future discussions on payment reforms. Design …

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Incidence and Clinical Outcomes of Radiation-Induced Second Malignancies Among Patients Treated for HPV-Associated Oropharyngeal Cancers at a Single Institution

Erik M. Davies, Chanakyaram A. Reddy, Kate Dennert, Richard W. Davis et autres

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Prognostic utility of a personalized ctDNA minimal residual disease test in patients undergoing curative resection of HPV-negative head and neck squamous cell carcinoma.

Natalya Karasik, Jacob A. Miller, Chandana A. Reddy, Shauna Campbell et autres

e18113 Background: Circulating tumor DNA (ctDNA) is emerging as a powerful prognostic biomarker as a minimal residual disease (MRD) test in the postoperative(postop) setting in multiple solid tumors. This study reports an initial experience using a personalized ctDNA assay after curative surgery …

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Imaging Extranodal Extension (iENE) Predicts Higher Rates of Distant Recurrence for Human Papillomavirus-Positive Oropharyngeal Cancer

Cong Fan, Jonathan Wei Jie Lee, Sarah Jane Stock, Neil McIver Woody et autres

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Management of Clinically Node‐Negative Salivary Gland Cancer: Observation, Neck Dissection, or Neck Irradiation?

Evelyn O. Ilori, Neil McIver Woody, Bryan B. Hair, Lisa A Rybicki et autres

INTRODUCTION: Salivary gland malignancies are heterogeneous tumors with highly variable outcomes. Elective neck management options include observation, neck dissection (ND), and neck irradiation (NI). We sought to compare outcomes of cN0 salivary gland cancer by elective neck management. METHODS: An IRB-approved registry …

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Iliac Crest Bone Graft and Fascia Lata Free Flap for Rescue of Mandibular Osteoradionecrosis

Derek J. Vos, Sara W. Liu, Khashayar Arianpour, Peter J. Ciolek et autres

OBJECTIVE: Describe the use, indications, and outcomes of iliac crest bone graft (ICBG) with concomitant anterolateral thigh fascia lata (ALTFL) rescue flap for the management of mandibular osteoradionecrosis (ORN). STUDY DESIGN: Retrospective chart review. SETTING: Single institution. METHODS: Retrospective chart review of …

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Highly-multiplex detection of plasma cell-free human papillomavirus-16 DNA in oropharyngeal carcinoma

Natalya Karasik, Shauna R. Campbell, Neil McIver Woody, Jamie Ahn Ku et autres

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