Brian Marples

IP07-23 NEUTROPHIL DEPLETION MITIGATES POST-IRRADIATION BLADDER INFLAMMATION AND TISSUE REMODELING RESPONSES

Ryan D. Molony, Mahmudul Hasan Akash, Emma Ushchak, Angela Groves et autres

Targeting SMPDL3B to Ameliorate Radiation- and Cisplatin-Induced Renal Toxicity

Anis Ahmad, Shamroop Kumar Mallela, Saba A. Ansari, Mohammed Alnukhali et autres

Kidney toxicity remains a major dose-limiting complication of radiation therapy and platinum-based chemotherapy, yet the molecular determinants of renal susceptibility and resilience to these genotoxic treatments are incompletely understood. Podocytes are particularly vulnerable to such insults, and emerging evidence implicates lipid dysregulation …

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Spatially fractionated radiation therapy for treating recurrent glioblastoma: a dosimetric feasibility study

Yuwei Zhou, Sean Tanny, Michael T. Milano, Brian Marples et autres

Objective: Spatially fractionated radiation therapy (SFRT) shows promise for treating bulky, advanced, or recurrent tumors. To evaluate the feasibility of SFRT for patients with recurrent glioblastoma (GBM), we conducted a planning study involving 14 patients, analyzing vertex target volume (VTV) contours and …

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Wide-Angle Lung Experiment Segmentation (WALES): Effective quantitative assessment of lung pathology in model systems

Lewis J. Drakeley, Uzair Tahamid Siam, Eric Hernady, Nicole D. Paris et autres

For preclinical studies, the standard practice for evaluating lung injury usually involves an assessment of pulmonary histopathology by a certified pathologist. This is typically accomplished by light microscopy using a semiquantitative four-point scale. In contrast, automated image analysis software allows a more …

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SMPDL3b Induction Preserves Kidney Function and Lipid Homeostasis Following Radiation and Cisplatin Treatment

Anis Ahmad, Mohammed Alnukhali, N.R. Ahmad, Saba Ansari et autres

Background: Cancer survivors treated with radiation and cisplatin often develop chronic kidney injury, yet the mechanisms remain unclear. Podocytes are particularly vulnerable to cytotoxic stress. SMPDL3b, a lipid-modifying enzyme enriched in podocytes, may protect against renal injury by preserving structure and regulating …

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Influenza A Virus after Radiotherapy Amplifies Lung Injury and Monocyte-derived Macrophage Responses

Angela M. Groves, Carl J. Johnston, Nicole D. Paris, Noah Salama et autres

Improvements in radiation therapy (RT) for thoracic cancers have increased survival; thus, preventing radiotoxicity in normal lung tissue becomes even more important. Respiratory infection is a lung stressor that increases the risk of RT toxicity. However, this risk factor remains understudied with …

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Extracellular vesicle proteomics identify neutrophils as potential mediators of bladder radiotoxicity in prostate cancer

Ryan D. Molony, Md Mahmudul Hasan Akash, Sarah L. Kerns, Brian Marples et autres

Radiation cystitis (RC) is a chronic debilitating complication that impacts 8-11% of patients with prostate cancer (PCa) after radiotherapy (RT), reducing quality of life and contributing to decisional regret. Reliable treatments to alleviate the symptoms of RC, which include gross hematuria, are …

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KDM3B Regulates Postradiation Fibrotic Responses in Prostate Stroma via N6-methyladenosine Modification of LOX

Antao Dong, Xin Sun, Lei Chen, Ying Tsai et autres

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Cryoablation and Intratumoral Immunotherapy for Breast Cancer: A Future Path to Cost-Effective De-Escalation for Larger Tumors, Lymph Nodes and Metastatic Disease

J. Fermanian, Robert C. Ward, Dennis R. Holmes, Ariel C. Fisher et autres

Cryoablation is a promising, cost-effective option to de-escalate surgical breast cancer morbidity, but presently is only suggested for breast cancers < 1.5 cm, in select candidates. Breast cancer cryoablation is not a reliably covered procedure by insurance and is mainly guided by …

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Supplementary Figure S3 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer

Manzur Farazi, Xin Yang, Carson J. Gehl, Gillian C. Barnett et autres

Figure S3 shows a Manhattan plot from the GWAS

Supplementary Figure S1 from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer

Manzur Farazi, Xin Yang, Carson J. Gehl, Gillian C. Barnett et autres

Figure S1 shows principal components analysis of participants from the RGC and REQUITE+URWCI cohorts.

Data from A Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer

Manzur Farazi, Xin Yang, Carson J. Gehl, Gillian C. Barnett et autres

AbstractBackground: Late bladder toxicity is a concern for patients receiving prostate cancer radiotherapy and negatively affects survivors. Few risk factors are known beyond the radiation dose and volume of bladder exposed. A polygenic risk score (PRS) could identify susceptible patients. Methods: A …