John E. Sims

Quantifying evidence for phenotypic specificity (PP4) for syndromic phenotypes: Large-scale integration of rare germline FH variants from diagnostic laboratory testing for HLRCC and renal cancer

Sophie Allen, Charlie F Rowlands, Samantha Butler, Miranda Durkie et autres

PURPOSE: Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a rare cancer susceptibility syndrome exclusively attributable to pathogenic variants in FH (HGNC:3700). This article quantitatively weights the phenotypic context (PP4/PS4) of such very rare variants in FH. METHODS: likelihood ratios (LLRs) as …

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P-022 Machine learning for clinical outcome prediction in cerebrovascular and endovascular neurosurgery: systematic review and meta-analysis

Haydn Hoffman, John E. Sims, Violiza Inoa, Daniel Hoit et autres

Background Machine learning (ML) may be superior to traditional methods for clinical outcome prediction. We sought to systematically review the literature on ML for clinical outcome prediction in cerebrovascular and endovascular neurosurgery. Methods A comprehensive literature search was performed, and original studies …

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Novel protein therapeutic joint retention strategy based on collagen‐binding Avimers

Joanne T. Hulme, Warren N. D’Souza, Helen J. McBride, Bo‐Rin Park Yoon et autres

Designing drugs to treat diseases associated with articular joints, particularly those targeting chondrocytes, is challenging due to unique local environmental constraints including the avascular nature of cartilage, the absence of a closed joint compartment, and a highly cross-linked extracellular matrix. In an …

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The Interleukin-1 System: Receptors, Ligands and Signals

Steven Dower, John E. Sims, Douglas Pat Cerretti, Timothy A. Bird

IL-36: An Epithelial Cytokine Important in Psoriasis

John E. Sims, Solenne Vigne, Cem Gabay, Jennifer E. Towne

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IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells

Solenne Vigne, Gaby Palmer, Praxedis Martin, Céline Lamacchia et autres

The interleukin-1 (IL-1) superfamily of cytokines comprises a set of pivotal mediators of inflammation. Among them, the action of IL-36 cytokines in immune responses has remained elusive. In a recent study, we demonstrated a direct effect of IL-36 on immune cells. Here …

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I08 IL-36 stimulates Th1 responses and is implicated in human psoriasis

John E. Sims

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P181 IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naïve CD4+ T cells

Solenne Vigne, Gaby Palmer, Paul L. Martin, Céline Lamacchia et autres

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Disposition of desfuroylceftiofur acetamide in serum, placental tissue, fetal fluids, and fetal tissues after administration of ceftiofur crystalline free acid (CCFA) to pony mares with placentitis

Margo L. Macpherson, Steeve Giguère, J.N. Hatzel, Małgorzata A. Pozor et autres

Macpherson, M. L., Giguère, S., Hatzel, J. N., Pozor, M., Benson, S., Diaw, M., Sanchez, L. C., Vickroy, T. W., Tell, L., Wetzlich, S., Sims, J. Disposition of desfuroylceftiofur acetamide in serum, placental tissue, fetal fluids, and fetal tissues after administration of …

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IL-36 in psoriasis

J.E. Towne, John E. Sims

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Neuron-Specific Effects of Interleukin-1β Are Mediated by a Novel Isoform of the IL-1 Receptor Accessory Protein

Yangyang Huang, Dirk E. Smith, Osvaldo Ibáñez-Sandoval, John E. Sims et autres

In the CNS, interleukin-1β (IL-1β) is synthesized and released during injury, infection, and disease, mediating inflammatory responses. However, IL-1β is also present in the brain under physiological conditions, and can influence hippocampal neuronal function. Several cell-specific IL-1-mediated signaling pathways and functions have …

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An introduction to the interleukin-1 family of cytokines

John E. Sims

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