Giorgia Catalano

Advanced Perfusion Techniques Level Liver Transplantation Outcomes With Different Donor Types: A Propensity Score-matched Analysis

Nicola De Stefano, Rebecca Panconesi, Grazia Labellarte, Fady Hashish et autres

BACKGROUND: Advanced perfusion techniques have been shown to improve liver transplantation (LT) outcomes in donation after determination of death by both circulatory (DCD) and neurological (DBD) criteria, but allocation strategies are still controversial. METHODS: This study compared the outcomes of controlled DCD …

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The pan - COVID - AGICT study. The impact of COVID-19 pandemic on surgically treated pancreatic cancer patients. A multicentric Italian study

Maria Pia Federica Dorma, Giuseppe Giuliani, Francesco Guerra, Francesco Santelli et autres

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Viability assessment of livers donated after circulatory determination of death during normothermic regional perfusion

Irene Steinberg, Damiano Patrono, Enrico De Cesaris, Michele Lucà et autres

Abstract Background Abdominal normothermic regional perfusion (A‐NRP) allows in‐situ reperfusion and recovery of abdominal organs metabolism in donors after circulatory death (DCD). Besides improving liver transplantation outcomes, liver injury and function can be assessed during A‐NRP. Methods To refine liver viability assessment …

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How to Preserve Steatotic Liver Grafts for Transplantation

Damiano Patrono, Nicola De Stefano, Elena Vissio, Ana Lavinia Apostu et autres

Liver allograft steatosis is a significant risk factor for postoperative graft dysfunction and has been associated with inferior patient and graft survival, particularly in the case of moderate or severe macrovesicular steatosis. In recent years, the increasing incidence of obesity and fatty …

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The MIS-COVID-AGICT Study: Trend of Minimally Invasive Surgery for Gastrointestinal Cancer Treatment During the First Waves of the COVID-19 Pandemic in Italy. Subgroup Analysis from the COVID-AGICT Study: COVID-19 and Advanced Gastrointestinal Cancer Surgical Treatment

Giuseppe Giuliani, Diego Coletta, Francesco Guerra, Sofia Esposito et autres

A preliminary analysis from the COVID-Advanced Gastrointestinal Cancer Surgical Treatment (AGICT) study showed that the rate of minimally invasive surgery (MIS) for elective and urgent procedures did not decrease during the pandemic year. In this article, we aimed to perform a subgroup …

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The COVID - AGICT study: COVID–19 and advanced gastro-intestinal cancer surgical treatment. A multicentric Italian study on the SARS-CoV-2 pandemic impact on gastro-intestinal cancers surgical treatment during the 2020. Analysis of perioperative and short-term oncological outcomes

Giuseppe Giuliani, Francesco Guerra, Simona Messinese, Francesco Santelli et autres

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Outcome of liver transplantation with grafts from brain-dead donors treated with dual hypothermic oxygenated machine perfusion, with particular reference to elderly donors

Damiano Patrono, Davide Cussa, Veronica Sciannameo, Elena Montanari et autres

Prompted by the utilization of extended criteria donors, dual hypothermic oxygenated machine perfusion (D-HOPE) was introduced in liver transplantation to improve preservation. When donors after neurological determination of death (DBD) are used, D-HOPE effect on graft outcomes is unclear. To assess D-HOPE …

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Clinical assessment of liver metabolism during hypothermic oxygenated machine perfusion using microdialysis

Damiano Patrono, Dorotea Roggio, Anna Teresa Mazzeo, Giorgia Catalano et autres

BACKGROUND: While growing evidence supports the use of hypothermic oxygenated machine perfusion (HOPE) in liver transplantation, its effects on liver metabolism are still incompletely understood. METHODS: To assess liver metabolism during HOPE using microdialysis (MD), we conducted an open-label, observational pilot study …

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The Presence of Metastatic Thoracic Duct Lymph Nodes in Western Esophageal Cancer Patients: A Multinational Observational Study

Ingmar L. Defize, Stijn M.C. Gorgels, Elena Mazza, Bernadette Schurink et autres

BACKGROUND: The thoracic lymphadenectomy during an esophagectomy for esophageal cancer includes resection of the thoracic duct (TD) compartment containing the TD lymph nodes (TDLNs). The role of TD compartment resection is still a topic of debate since metastatic TDLNs have only been …

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LESSONS LEARNED FROM PERFUSATE ANALYSIS DURING DUAL HYPOTHERMIC OXYGENATED MACHINE PERFUSION OF LIVER GRAFTS

Damiano Patrono, Giorgia Catalano, Giorgia Rizza, Nicola Lavorato et autres

Background: Liver graft viability assessment has long been considered a limit of hypothermic oxygenated machine perfusion (HOPE). Aim of this study was assessing correlations of easily available perfusate parameters (PP) (AST, ALT, LDH, glucose, lactate and pH) with graft features and outcome. …

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EVALUATION OF THE MECHANISM OF ACTION OF HEPATIC HYPOTHERMIC OXYGENATED MACHINE PERFUSION (HOPE) USING MICRODIALYSIS IN A CLINICAL SETTING

Damiano Patrono, Anna Teresa Mazzeo, Dorotea Roggio, Giorgia Catalano et autres

Introduction: HOPE is progressively entering the clinical practice, but the understanding of its mechanism of action is still incomplete. Microdialysis (MD) offers the possibility to sample interstitial fluid during both static cold storage (SCS) and HOPE. Materials and Methods: Dual HOPE was …

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Perfusate Analysis During Dual Hypothermic Oxygenated Machine Perfusion of Liver Grafts: Correlations With Donor Factors and Early Outcomes

Damiano Patrono, Giorgia Catalano, Giorgia Rizza, Nicola Lavorato et autres

BACKGROUND: Liver graft viability assessment has long been considered a limit of hypothermic oxygenated machine perfusion (HOPE). Aim of this study was assessing correlations of easily available perfusate parameters (PP) (aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, glucose, lactate, and pH) with graft …

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