Natalie Smyth

Depression Genetics in Africa (DepGenAfrica): protocol for the first large-scale case-control study of major depressive disorder among continental Africans

Adeniran Okewole, Jared G. Maina, Wisdom P. Nakanga, Vivien J. Chebii et autres

Background Major Depressive Disorder (MDD) is a disabling condition that arises from the interplay of genetic and environmental risk factors. Most genetic studies of depression to date have failed to include continental African populations. As a result, risk-associated genetic variation among African …

A map of blood regulatory variation in South Africans enables GWAS interpretation

Stephane E. Castel, Furahini D Tluway, Anne-Katrin Emde, Natalie Smyth et autres

Functional genomics resources are critical for interpreting human genetic studies, but currently they are predominantly from European-ancestry individuals. Here we present the South African Blood Regulatory (SABR) resource, a map of blood regulatory variation that includes three South Eastern Bantu-speaking groups. Using …

us, Afrique du Sud (code pays fourni par la source)

Factors associated with frequency of fruit and vegetable consumption among selected sub-Saharan African populations: evidence from the Cardiovascular H3Africa Innovation Resource Project

Akinkunmi Paul Okekunle, Osahon Jeffery Asowata, Onoja Akpa, Adekunle Fakunle et autres

BACKGROUND: Frequent fruit and vegetable consumption is considered a promising dietary behaviour that protects health. However, most existing studies about the factors associated with this phenomenon among Africans are based on single-country reports, apart from one meta-regression combining smaller studies. This study …

kr, Nigéria, us, Afrique du Sud, Kenya, Ghana, lb (code pays fourni par la source)

The African Liver Tissue Biorepository Consortium: Capacitating Population-Appropriate Drug Metabolism, Pharmacokinetics, and Pharmacogenetics Research in Drug Discovery and Development

Collen Masimirembwa, Michèle Ramsay, Jean Botha, Ewa Ellis et autres

se, Afrique du Sud, us, Zimbabwe (code pays fourni par la source)

Genetic Associations of LDLR, APOB and LDLRAP1 Variants with LDL-cholesterol Levels Among Africans

Natalie Smyth, M Hayat, Robyn Kerr, Frederick J. Raal et autres

Afrique du Sud (code pays fourni par la source)

Population specific genetic heterogeneity of familial hypercholesterolemia in South Africa

Natalie Smyth, Michèle Ramsay, Frederick J. Raal

PURPOSE OF REVIEW: To describe the prevalence and population-specific genetic heterogeneity of familial hypercholesterolemia in South Africa. RECENT FINDINGS: This review highlights the paucity of data on familial hypercholesterolemia in South Africa, and the urgent need to uncover the mutation profiles in …

Afrique du Sud (code pays fourni par la source)