Monica Pernia Marin

The Elusive Origin of Glioblastoma: Where Do We Stand?

Monica Pernia Marin, Hamed Almabrok, M. L. Miller, Aya Haggiagi

Glioblastoma (GBM) remains one of the most lethal cancers, and despite advancements in understanding its underlying molecular signature, effective therapeutics are still lacking. The multifaceted challenges of designing treatments for GBM are compounded by the inability to identify a definitive cell of …

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INNV-17. Diagnostic Performance and Prognostic Value of the G8 Screening Tool in Older Adults with Newly Diagnosed Glioblastoma, IDH Wild-Type

Monica Pernia Marin, Laura Donovan, Fábio M. Iwamoto, Rajiv Magge et autres

Abstract Older adults (OA) represent a functionally heterogeneous population. While aging increases vulnerability to disease, not all OA are frail. Cancer, particularly glioblastoma (GBM), is more frequent in OA, with a median age of cancer-related death exceeding 70 years in the U.S. …

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Alpha-1 antitrypsin deficiency: genetics, clinical manifestations, AI prognostics, and advanced imaging in liver disease

Islam Rajab, Monica Pernia Marin, Abdalhakim Shubietah, Mohammad Bdair et autres

gene, resulting in reduced or dysfunctional alpha-1 antitrypsin (AAT) protein. This deficiency leads to progressive lung and liver diseases, including emphysema, chronic obstructive pulmonary disease, and cirrhosis. Despite its clinical significance, AATD remains underdiagnosed, delaying treatment. This review explores the molecular mechanisms …

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Fibrosis and cancer intersection

Mary Salvatore, Monica Pernia Marin

Despite the decrease in cancer related deaths over the past 30 years, the incidence of six of the top ten cancers is increasing; breast, prostate, uterus, melanoma, pancreas, and colorectal cancer [ 1 ]. This alarming statistic raises the question of what …

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Fractionated robotic radiosurgery for unfavorable nonfunctioning pituitary macroadenoma: 5-year outcomes from a single institution protocol

Akrita Bhatnagar, Monica Pernia Marin, Jonathan W. Lischalk, Min Ji Koh et autres

Objective Nonfunctioning macroadenoma is a commonly diagnosed pituitary tumor. Resection is the favored treatment, with radiosurgery often utilized for residual or progressing disease. Long-term outcomes are established in the literature for single-fraction frame-based radiosurgery, but mature outcomes are lacking for fractionated frameless …

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Mentors without Borders: Bridging global gaps in medical and radiological education

Monica Pernia Marin, Vikas Burugu, Sofia Maria Tarchi, Reza Solemani et autres

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Breast Collagen Organization: Variance by Patient Age and Breast Quadrant

Arnold Caleb Asiimwe, Monica Pernia Marin, Mary Salvatore

Breast density is an important marker for increased breast cancer risk, but the ideal marker would be more specific. Breast compactness, which reflects the focal density of collagen fibers, parallels breast cancer occurrence being highest in the upper outer quadrants of the …

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Radiology of fibrosis part III: genitourinary system

Sofia Maria Tarchi, Mary Salvatore, Thillai V. Sekar, Kathleen M. Capaccione et autres

Fibrosis is a pathological process involving the abnormal deposition of connective tissue, resulting from improper tissue repair in response to sustained injury caused by hypoxia, infection, or physical damage. It can impact any organ, leading to their dysfunction and eventual failure. Additionally, …

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Radiology of fibrosis part II: abdominal organs

Sofia Maria Tarchi, Mary Salvatore, Thillai V. Sekar, Kathleen M. Capaccione et autres

Fibrosis is the aberrant process of connective tissue deposition from abnormal tissue repair in response to sustained tissue injury caused by hypoxia, infection, or physical damage. It can affect almost all organs in the body causing dysfunction and ultimate organ failure. Tissue …

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Radiology of fibrosis. Part I: Thoracic organs

Sofia Maria Tarchi, Mary Salvatore, Thillai V. Sekar, Kathleen M. Capaccione et autres

Sustained injury from factors such as hypoxia, infection, or physical damage may provoke improper tissue repair and the anomalous deposition of connective tissue that causes fibrosis. This phenomenon may take place in any organ, ultimately leading to their dysfunction and eventual failure. …

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A Thorough Literature Review of the Potential Benefits and Drawbacks of Long-Term Aspirin Use for the Primary Prevention of Cardiovascular Disease

Abdalhakim Shubietah, Monica Pernia Marin, Islam Rajab, Majd Oweidat et autres

This article examines the role of aspirin in the primary prevention of cardiovascular disease. It highlights findings from major studies such as ASPREE (ASPirin in Reducing Events in the Elderly), ARRIVE (Aspirin to Reduce Risk of Initial Vascular Events), and ASPREE-XT (ASPirin …

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Breast stiffness, a risk factor for cancer and the role of radiology for diagnosis

Sofia Maria Tarchi, Monica Pernia Marin, Md Murad Hossain, Mary Salvatore

Over the last five decades, breast density has been associated with increased risk of developing breast cancer. Mammographically dense breasts are considered those belonging to the heterogeneously dense breasts, and extremely dense breasts subgroups according to the American College of Radiology's Breast …

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