Edit Mesterházy

Tristhiolato Pseudopeptides Bind Arsenic(III) in an AsS3 Coordination Environment Imitating Metalloid Binding Sites in Proteins

Levente I. Szekeres, Pascale Maldivi, Colette Lebrun, Christelle Gateau et autres

High Resolution Image Download MS PowerPoint Slide The As III binding of two NTA-based tripodal pseudopeptides, possessing three cysteine (ligand L 1 ) or d -penicillamine residues (ligand L 2 ) as potential coordinating groups for soft semimetals or metal ions, was …

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Synergetic Antimicrobial Activity and Mechanism of Clotrimazole-Linked CO-Releasing Molecules

Sofia S. Mendes, Joana Marques, Edit Mesterházy, Jan Straetener et autres

High Resolution Image Download MS PowerPoint Slide Several metal-based carbon monoxide-releasing molecules (CORMs) are active CO donors with established antibacterial activity. Among them, CORM conjugates with azole antibiotics of type [Mn(CO) 3 (2,2′-bipyridyl)(azole)] + display important synergies against several microbes. We carried …

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New peptidic Cu(I) chelators as potential candidates for the treatment of Wilson’s disease

Edit Mesterházy

Le cuivre est un micronutriment essentiel qui participe à de nombreux processus biologiques. Cependant, le cuivre libre est toxique pour l’organisme parce qu’il catalyse une réaction de type Fenton formant des espèces réactives de l’oxygène. Par conséquent la concentration en cuivre est …

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A Constrained Tetrapeptide as a Model of Cu(I) Binding Sites Involving Cu4S6 Clusters in Proteins

Edit Mesterházy, Colette Lebrun, Attila Jancsó, Pascale Delangle

Peptide design is an efficient strategy to create relevant models of natural metal binding sites found in proteins. The two short tetrapeptides Ac-Cys- d Pro-Pro-Cys-NH 2 (C d PPC) and Ac-Cys-Pro-Gly-Cys-NH 2 (CPGC) were synthesized and studied as mimics of Cu(I) binding …

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Short oligopeptides with three cysteine residues as models of sulphur-rich Cu( i )- and Hg( ii )-binding sites in proteins

Edit Mesterházy, Colette Lebrun, Serge Crouzy, Attila Jancsó et autres

The essential Cu(i) and the toxic Hg(ii) ions possess similar coordination properties, and therefore, similar cysteine rich proteins participate in the control of their intracellular concentration. In this work we present the metal binding properties of linear and cyclic model peptides incorporating …

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Oligopeptide models of the metal binding loop of the bacterial copper efflux regulator protein CueR as potential Cu(I) chelators

Edit Mesterházy, Bastien Boff, Colette Lebrun, Pascale Delangle et autres

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Competition of zinc(II) with cadmium(II) or mercury(II) in binding to a 12-mer peptide

Attila Jancsó, Béla Gyurcsik, Edit Mesterházy, Róbert Berkecz

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