Xiaotong Jia

Strain rate–dependent indentation responses and microstructural evolution mechanisms of aluminum oxynitride ceramics

Xiaotong Jia, Xiu‐Le Cao, Xingwang Cheng, Zhaohui Zhang et autres

Abstract Aluminum oxynitride (AlON) ceramics, valued for their superior mechanical properties and optical transparency, are promising candidates for advanced armor protection. However, their mechanical response under varying loading rates remains insufficiently understood, constraining reliability‐based design and performance optimization for impact conditions. In …

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Insights into the local mechanical response and microplastic deformation mechanisms of AlON ceramics

Xiaotong Jia, Zhaohui Zhang, Qiang Wang, Jin-Zhao Zhou et autres

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Exploring the macrocyclic chemical space for heuristic drug design with deep learning models

Feng Hu, Xiaotong Jia, Wenjie Liao, Ziqi Chen et autres

Macrocyclic compounds hold great promise as therapeutic agents. However, their structural optimization remains constrained by the limited availability of bioactive candidates, which in turn hampers the systematic exploration of structure-activity relationships. Here we introduce CycleGPT, a generative chemical language model designed specifically …

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Composition design and oxidation mechanism of quaternary single-phase (HfZrTaCr)B2: Phase evolution and synergistic CrTaO4@(Hf, Zr)O2/B2O3 dual diffusion barrier at elevated temperatures

Wenjun Li, Zhaohui Zhang, Xiaotong Jia, Jin-Zhao Zhou et autres

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Spark plasma sintered α-SiC/β-SiC composites derived from polymer precursors: Microstructure and mechanical properties

Jin-Zhao Zhou, Xiaotong Jia, Xingwang Cheng, Qiang Wang et autres

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Ultra-High Strength and Specific Strength in Ti61Al16Cr10Nb8V5 Multi-Principal Element Alloy: Quasi-Static and Dynamic Deformation and Fracture Mechanisms

Yang-Yu He, Yifan Liu, Yichen Cheng, Xiaotong Jia et autres

This study investigates the deformation and fracture mechanisms of a Ti61Al16Cr10Nb8V5 multi-principal element alloy (Ti61V5 alloy) under quasi-static and dynamic compression. The alloy comprises an equiaxed BCC matrix (~35 μm) with uniformly dispersed nano-sized B2 precipitates and a ~3.5% HCP phase along …

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Attaining superior high-temperature strength in (TiC + (TiZr)5Si3)/TA15 composites through spark plasma sintering and heat treatment

Qiang Wang, Xingwang Cheng, Xiaotong Jia, Yang-Yu He et autres

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Design, Synthesis, and Biological Evaluation of Macrocyclic 2-Amino-4-phenylaminopyrimidine Derivatives as Potent JAK2 Inhibitors

Wenyi Mei, Xiaotong Jia, Feng Hu, Wenjie Liao et autres

Janus kinase 2 with the activating mutation V617F is a potential target for the treatment of myeloproliferative neoplasms. Current JAK2 inhibitors often suffer from multiple pharmacological limitations such as limited selectivity and rapid metabolic clearance. In this study, we describe the design, …

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Exploring the macrocyclic chemical space for heuristic drug design with deep learning models

Feng Hu, Xiaotong Jia, Wenjie Liao, Ziqi Chen et autres

Macrocyclic compounds have shown great potential as therapeutic agents due to their distinctive structural and pharmacological properties. However, structural optimization of macrocycles—a critical step in the rational design of macrocyclic drugs—remains constrained by the limited availability of bioactive candidates, which in turn …

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A study on the microstructural evolution and strengthening mechanisms of the lightweight (Ti61Al16Cr10Nb8V5)99.6Si0.4 multi-principal alloy with excellent high-temperature mechanical properties

Yang-Yu He, Xingwang Cheng, Yifan Liu, Yichen Cheng et autres

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Achieving high strength and ductility in multiscale (TiC+(TiZr)5Si3)/TA15 composites via spark plasma sintering and hot rolling

Qiang Wang, Zhaohui Zhang, Xingwang Cheng, Xiaotong Jia et autres

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Fabrication of high-performance (TiC + (TiZr)5Si3)/TA15 composites via spark plasma extrusion

Qiang Wang, Xingwang Cheng, Xiaotong Jia, Yang-Yu He et autres

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