Chen Gao

Analysis of disease burden of osteoarthritis in China from 1990 to 2021 and projections for 2022–2044

Binni Yang, Zhe Wang, Wantian Feng, Chen Gao

Objective: To analyze the secular trend of osteoarthritis (OA) disease burden in China from 1990 to 2021 and predict future burden changes spanning 2022-2044 to support targeted public health intervention. Methods: Based on the Global Burden of Disease 2021 (supplemented with partial …

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Low-Compilation-Cost Register Allocation in LLVM-Based Binary Translation

Xiangwei Meng, Chen Gao, Wei Li, Fengyuan Ren

Efficiently allocating guest architecture registers to host registers is a crucial technique for improving performance in dynamic binary translation. Translators typically enlarge code regions to reduce context-switching overhead and expose more optimization opportunities. Traditional approaches load guest registers upon entering a code …

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Neutrophil Extracellular Traps and Intestinal Diseases: A Narrative Review

Z Wang, Binni Yang, Zhenghong Li, Chen Gao

Neutrophil extracellular traps (NETs) are a network-like structure released by neutrophils into the extracellular space in response to various stimuli, with DNA as the main component, to which histones, granulins, cytoplasmic proteins, and other proteins are attached. Previous studies have shown that …

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Monocarboxylate transporter dependent mechanism is involved in proliferation, migration, and invasion of human glioblastoma cell lines via activation of PI3K/Akt signaling pathway

Chen Gao, Binni Yang, Yurong Li, Wenjuan Pei

Glioblastoma multiforme is one of the most common primary tumors of the central nervous system, with a very poor prognosis. Cancer cells have been observed to upregulate pH regulators, such as monocarboxylate transporters (MCTs), with an increase in MCT4 expression being observed …

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Injectable polypeptide-polysaccharide depot for preventing postoperative tumor recurrence by concurrent in situ chemotherapy and brachytherapy

Jiaming Fan, Xiaoyao Cai, Han Gui, Mei Lin et autres

injection in a postoperative model of anaplasia Wilms' tumor. After injection at the cavity of tumor excision, responsively-released vincristine and the radioactive iodine-125 exerted excellent killing effects on residual tumor cells, inhibiting tumor relapse and liver metastasis of the recurrent tumor. Hence, …

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Trends and hotspots of energy-based imaging in thoracic disease: a bibliometric analysis

Yufan Chen, Ting Wu, Yangtong Zhu, Jiawei Chen et autres

OBJECTIVE: To conduct a bibliometric analysis of the prospects and obstacles associated with dual- and multi-energy CT in thoracic disease, emphasizing its current standing, advantages, and areas requiring attention. METHODS: The Web of Science Core Collection was queried for relevant publications in …

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A monocarboxylate transporter-dependent mechanism confers resistance to exercise-induced fatigue in a high-altitude hypoxic environment

Chen Gao, Binni Yang, Yurong Li, Wenjuan Pei

The body is more prone to fatigue in a high-altitude hypoxic environment, in which fatigue occurs in both peripheral muscles and the central nervous system (CNS). The key factor determining the latter is the imbalance in brain energy metabolism. During strenuous exercise, …

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Monocarboxylate transporter-dependent mechanism is involved in the adaptability of the body to exercise-induced fatigue under high-altitude hypoxia environment

Chen Gao, Binni Yang, Yurong Li, Wenjuan Pei

Under high-altitude hypoxia environment, the body is more prone to fatigue, which occurs in both peripheral muscles and the central nervous system (CNS). The key factor determining the latter is the imbalance of brain energy metabolism, which makes it difficult to maintain …

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Risk Factors for Recurrent L4-5 Disc Herniation After Percutaneous Endoscopic Transforaminal Discectomy: A Retrospective Analysis of 654 Cases

M Kong, Dan Xu, Chen Gao, Zhu K et autres

Meng Kong,1,2,* Derong Xu,1,* Changtong Gao,3 Kai Zhu,1 Shuo Han,1,2 Hao Zhang,1,2 Chuanli Zhou,1 Xuexiao Ma1 1Department of Spinal Surgery, The Affiliated Hospital of Qingdao University, Qing’dao, Shandong Province 266000, People’s Republic of China; 2Department of Medicine, Qingdao University, Qing’dao, Shandong Province …

Development of a risk calculator to predict spontaneous stone passage in patients with acute ureteric colic

Chen Gao, Matilda Peters, Keerthanaa Jayaraajan, M. Todd et autres

Efficiency and influence factors of stereotactic precision aspiration in the treatment of primary brain stem hemorrhage

Fengqiang Liu, Zefeng Wang, Xiaobo Yu, Jian Zheng et autres

Objective To investigate the efficiency and influence factors of stereotactic precise aspiration in treatment of primary brainstem hemorrhage. Methods A total of 47 patients with primary brainstem hemorrhage who underwent stereotactic precision aspiration from March 2014 to September 2018 at Department of …

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Dong Hua: choose a hospital and concentrate on one thing

Chen Gao, Jie Dong

Wuxi, a city in the south of Jiangsu Province, is hailed as “the pearl in the Taihu Lake”. The city is home to the 43-year-old Affiliated Hospital of Jiangnan University (Wuxi Fourth People’s Hospital).