Valeria D’Argenio

Targeted lipidomics showed altered serum phosphatidylcholine levels in fearful dogs

Luigi Sacchettino, Michele Costanzo, Sabrina Bianco, Iolanda Veneruso et autres

Fearfulness accounts for most disorders affecting family dogs, who generally experience several behavioral traits, including trembling, hiding, flinching at noises, panting, or ears held back. Intense and persistent exposure to threatening situations might escalate to phobia, which easily makes patients more prone …

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Methodological approaches for the characterization of long non-coding RNAs: current technologies and perspectives for laboratory medicine

Iolanda Veneruso, Luigi Liguori, Pegah GHOLAMPOUR, Flavia SORGIACOMO et autres

Long non-coding RNAs are emerging as key regulators of gene expression and cellular homeostasis, with increasing evidence supporting their involvement in physiological processes and in the pathogenesis of several diseases. Their tissue specificity, low abundance, structural complexity and context-dependent functions make their …

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Early mitophagy defects and impaired mitochondrial energy metabolism drive target organ damage progression: lessons from the Fabry heart

Jessica Gambardella, Antonella Fiordelisi, Federica Andrea Cerasuolo, Antonietta Buonaiuto et autres

Abstract Increased literature support the pathogenetic role of dysfunctional energetic metabolism in the setup and progression of organ damage and failure. Genetic diseases often offer the possibility to investigate pathogenetic mechanisms. In particular, excessive cardiac damage is the most frequent cause of …

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Gut mucosa-associated microbiota signatures in healthy individuals and patients at different stages of liver disease: a pilot study

Debora Compare, Bruno Fosso, Marcella Nunziato, Costantino Sgamato et autres

BACKGROUND: The gut microbiota plays a key role in the progression of chronic liver disease and the development of hepatocellular carcinoma (HCC). However, findings on microbiota composition in such patients remain inconsistent, likely due to differences in disease aetiology and sample type. …

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Efficacy of nutraceutical supplements containing Passiflora incarnata L., Withania somnifera (L.) Dunal and Taraxacum officinale (L.) weber ex F.H.Wigg. on markers of inflammation, oxidative stress and gut microbiota in senior dogs

Roberto Ciarcia, Consiglia Longobardi, Valeria Iervolino, Tommaso Manenti et autres

Introduction Aging in dogs is a complex phenomenon characterized by metabolic, immunological and neurological alterations that may result in chronic inflammation, oxidative stress, and intestinal microbiota changing that can compromise dogs’ overall health. Phytotherapeutics represents a promising approach to improve the quality …

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Toward a Multi-Trait Genetic Panel Targeting Training, Rehabilitation, and Chronic Disease Prevention: A Narrative Review

A Imperatore, Cristina Mennitti, Giulia De Fonzo, Raffaele Amitrano et autres

Athletic performance results from complex interactions between genetic and environmental factors. This review compiles and synthesizes available literature on polymorphic genes associated with endurance, power, and strength performance, as well as their links to injury susceptibility and chronic metabolic diseases. Endurance performance …

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Genomica clinica in medicina di laboratorio

Valeria D’Argenio, Lucio Pastore

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Genetic Landscape of Familial Melanoma

Carmela Scarano, Iolanda Veneruso, Valeria D’Argenio

is a highly penetrant gene associated to familial melanomas, being responsible of up to 40% of the cases. Other high, moderate, and low penetrance genes are being discovered, even if their own contribution to melanoma risk is still under debate. Indeed, next …

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Establishing Best Practices for Clinical GWAS: Tackling Imputation and Data Quality Challenges

Giorgio Casaburi, Ron M. McCullough, Valeria D’Argenio

Genome-wide association studies (GWASs) play a central role in precision medicine, powering a range of clinical applications from pharmacogenomics to disease risk prediction. A critical component of GWASs is genotype imputation, a computational method used to infer untyped genetic variants. While imputation …

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Diagnosi molecolare delle nefropatie ereditarie: applicazioni cliniche dei pannelli Next Generation Sequencing

Carmela Scarano, Iolanda Veneruso, Rita ROMANO, Valeria D’Argenio

Inherited kidney diseases (IKDs) represent a heterogeneous group of disorders that can manifest at any age and account for a significant proportion of chronic kidney disease (CKD) cases with unknown etiology. Their genetic complexity and phenotypic variability often make etiological diagnosis challenging. …

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Rapid and Cost-Effective Diagnostic Blot Assays Based on the Use of Plant-Produced Recombinant Antigens: Lessons Learned from the SARS-CoV-2 RBD Antigen

Chiara Miele, Dania Ramadan, Leonardo Lupacchini, Carla Marusic et autres

The ongoing demand for reliable, cost-effective, and scalable diagnostic solutions during the COVID-19 pandemic emphasized the need for innovative production platforms. In this study, we present a plant-based molecular farming (PMF) strategy for the production of the receptor-binding domain (RBD) of the …

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Rapid and Cost-Effective Diagnostic Blot Assays Based on the Use of Plant-Produced Recombinant Antigens: A Lesson Learned by SARS-CoV-2 RBD Antigen

Chiara Miele, Dania Ramadan, Leonardo Lupacchini, Carla Marusic et autres

The ongoing demand for reliable, cost-effective, and scalable diagnostic solutions during the SARS-CoV-2 pandemic has highlighted the need for innovative production platforms. Here, we present a plant-based molecular farming (PMF) strategy for the production of the receptor-binding domain (RBD) of the SARS-CoV-2 …

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