Guangdi Li

A Supervised Learning Approach for Accurate and Efficient Identification of Chikungunya Virus Lineages and Signature Mutations

Miao Miao, Yameng Fan, Jiao Tan, Xiaobin Hu et autres

Chikungunya virus (CHIKV) poses a significant public health threat, and its continuous evolution necessitates high-resolution genomic surveillance. Current methods lack the speed and resolution to efficiently discriminate sub-lineages. To address this, we developed CHIKVGenotyper, an interpretable machine learning framework for high-resolution CHIKV …

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Research Progress and Current Status of High-Speed Precision Maize Seed Metering Devices

Shibin Yan, Fazhan Yang, Jing Li, Xue Wang et autres

With the advancement of precision agriculture technology, achieving high-accuracy seed metering under high-speed operating conditions has become a core challenge in enhancing maize production efficiency. This paper system-atically reviews the research progress and current status of high-speed precision maize seed metering devices, …

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Mowing intensifies plant phosphorus limitation and phosphorus acquisition regulation under N fertilization in the temperate alkaline meadow

Haiyan Fu, Jibo Shi, Xiaoying Chen, Yu Tian et autres

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AntiviralDB: an expert-curated database of antiviral agents against human infectious diseases

Jie Huang, Qixiang Song, Pan Zhang, Lei Deng et autres

ABSTRACT Viral infectious diseases have caused millions of deaths worldwide. Antiviral agents are critical for controlling these infections; however, an open-access database dedicated specifically to antiviral agents remains unavailable. Here, we present AntiviralDB ( https://www.antiviraldb.com/ ), an expert-curated resource that compiles both …

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Circular RNA PVT1 promotes osteoarthritis progression through the miR-550a-3p/CX3CR1 pathway: A mechanistic study

Xingyu Liu, Guangdi Li, Lanqing Yang, Ningning Pan et autres

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Lenacapavir: A capsid inhibitor for HIV-1 treatment and prevention

Erik De Clercq, Y Zhang, Guangdi Li, Yelin Deng et autres

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Association between respiratory pathogens and severe clinical outcomes in people living with HIV-1 and pulmonary infections: A 180-day longitudinal cohort study

Yue Wang, Jing Cao, Qi Liu, Jie Huang et autres

BACKGROUND: Many respiratory pathogens have been identified in people living with HIV-1 and pulmonary infection, but their impact on clinical outcomes remains largely unclear. METHODS: Metagenomic sequencing and traditional laboratory diagnostics were applied to identify bacterial, viral, and fungal respiratory pathogens. Clinical …

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The Effect of HBV Therapy on Glycemic Control in HBV‐Infected Patients With Diabetes: A 90‐day Multicenter Study

Qi Liu, Jie Huang, Jingyi Hu, Yujing Ding et autres

Patients with diabetes are at increased risk of HBV infection; however, the effects of HBV infection and anti-HBV therapy on the management of type 1 diabetes (T1D), type 2 diabetes (T2D), and latent autoimmune diabetes in adults (LADA) remain unclear. From 2016 …

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Circular Rna Pvt1 Promotes Osteoarthritis Progression Through the Mir-550a-3p/Cx3cr1 Pathway: A Mechanistic Study

Xingyu Liu, Guangdi Li, Lanqing Yang, Ningning Pan et autres

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HCoVDB: a comprehensive database encompassing viral genomes, drug targets, and therapeutics of human coronaviruses

Pan Zhang, Tianxiang Ouyang, Xiaowen Hu, Jie Huang et autres

Over the past few decades, coronavirus outbreaks have been reported globally. To date, seven human coronaviruses have been identified, among which only SARS-CoV-2 has been extensively studied, resulting in the development of several approved antiviral drugs. To effectively combat both current and …

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Effects of nitrogen enrichment on soil enzyme activities in grassland ecosystems in China: A multilevel meta-analysis

M. Motior Rahman, Ruonan Ma, Qiang Li, Yingxin HUANG et autres

Nitrogen (N) enrichment has resulted in widespread alteration of grassland ecosystem processes and functions mainly through disturbance in soil enzyme activities. However, we lack a comprehensive understanding of how N deposition affects specific key soil enzymes that mediate plant-soil feedback of grassland. …

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Transcriptome combined with single cell to explore hypoxia-related biomarkers in osteoarthritis

Xingyu Liu, Guangdi Li, Lanqing Yang, Long Li et autres

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