Xuezhu Feng

rRNA intermediates associate with nucleolar reshaping in C. elegans

Jiewei Cheng, Lu Liu, Demin Xu, Yuxia Chen et autres

The nucleolus is a multilayered organelle essential for ribosome biogenesis, yet how ribosomal RNA (rRNA) events coordinate its organization remains unclear. We previously reported that the accumulation of 27SA2 pre-rRNA upon class I RPLs (large subunit ribosomal proteins) depletion accompanies the formation …

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Identification of a somatic H3K23me3 methyltransferase SET-19 in C. elegans

Mingjing Xu, Zixue Fan, Chaoyue Yan, Xiangyang Chen et autres

Abstract Histone methylation plays essential roles in modulating chromatin organization and gene expression. H3K23 methylation is a conserved histone modification, yet its biological roles and the enzymes responsible for its deposition remain poorly understood. Here, we show that the loss of set-19 …

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Heat stress-induced condensation of G3BP1 in perinuclear P-bodies in C. elegans’ germline

Diya Zang, Yifan Jing, Xinya Huang, Yan Kuang et autres

Abstract Stress granules (SGs) are essential subcellular assemblies that enable cells to adapt to environmental stress, and their dynamic assembly and disassembly are critical for maintaining cellular homeostasis and reproductive capacity. However, the function and regulation of stress granules in germline cells …

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The H3K27me3 reader UAD-2 recruits a TAF-12-containing transcription machinery to initiate piRNA expression within heterochromatic clusters

Xinya Huang, Yan Kuang, Meili Li, Minjie Hong et autres

Metazoans utilize the small RNA pathway to regulate gene expression and maintain genome integrity. This pathway directs histone H3 lysine 9 tri-methylation (H3K9me3) or histone H3 lysine 27 tri-methylation (H3K27me3) at target loci to induce transcriptional gene silencing. Interestingly, some small RNAs …

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TurboID-based proximity labeling identifies novel germline proteins that maintain E granule integrity and small RNA homeostasis in C. elegans

Kun Li, Xuezhu Feng, Ke Wang, Xiaona Huang et autres

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rRNA intermediates dictate nucleolar architecture in C. elegans

Jiewei Cheng, Liang Liu, Demin Xu, Yan Kuang et autres

Abstract The nucleolus is a multilayered, membraneless organelle essential for rRNA transcription, processing and ribosome assembly; however, it remains largely unclear whether and how these molecular events coordinate the organization of the multilayered nucleolar structure. We previously reported that the accumulation of …

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Nucleolar Proteomics Revealed the Regulation of RNA Exosome Localization by MTR4

Yaqian Zhang, Guangzhen Jiang, Ke Wang, Minjie Hong et autres

The nucleolus is the largest membrane-less organelle within the nucleus and plays critical roles in regulating the cell cycle, senescence, and stress responses. The RNA exosome is a multiprotein ribonucleolytic complex involved in RNA processing and degradation in the cytoplasm, the nucleus, …

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piRNA gene density and SUMOylation organize piRNA transcriptional condensate formation

Chengming Zhu, Xiaoyue Si, Xinhao Hou, Panpan Xu et autres

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The H3K27me3 reader UAD-2 recruits a TAF-12-containing transcription condensates to initiate piRNA expression within heterochromatic clusters

Xinya Huang, Yan Kuang, Ming‐Qing Li, Minjie Hong et autres

Abstract Metazoans utilize the small RNA pathway to regulate gene expression and maintain genome integrity. This pathway directs histone H3 lysine 9 tri-methylation (H3K9me3) or histone H3 lysine 27 tri-methylation (H3K27me3) at target loci to induce transcriptional gene silencing. Interestingly, some small …

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Peri-centrosomal localization of small interfering RNAs in C. elegans

Qile Jin, Xuezhu Feng, Minjie Hong, Ke Wang et autres

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Compartmentalized localization of perinuclear proteins within germ granules in C. elegans

Xiaona Huang, Xuezhu Feng, Yong-hong Yan, Demin Xu et autres

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TurboID-based proximity labeling identifies novel germline proteins that maintain E granule integrity and small RNA homeostasis in C. elegans

Kun Li, Xuezhu Feng, Ke Wang, Xiaona Huang et autres

Abstract Germ granules are biomolecular condensates composed of RNA and proteins that play crucial roles in RNA metabolism and posttranscriptional gene regulation. C. elegans germ granules consist of at least seven distinct subcompartments, including P granules, Z granules, Mutator foci, SIMR foci, …

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