Giulio Purgatorio

OC 56.3 Platelets Transfected with a KRASG12D-Silencing siRNA Reduce Pancreatic Tumor Mass In Vivo in Mice

Marco Malvestiti, Giulio Purgatorio, Enrica Cesari, Francesca Tondi et autres

by dynamic light scattering, zeta potential (ZP), and fluorescence spectroscopy.Chromogenic substrate and plasma clotting assays were used to study the effects of LPS on FXII activation and FXIIa activity.Results: O111:B4, O26:B6, and Rd2 produced aggregates with hydrodynamic diameters of 123 ± 38, …

Germline GATA2 variant disrupting endothelial eNOS function and angiogenesis can be restored by c-Jun/AP-1 upregulation

Giulio Purgatorio, Elisa Piselli, Giuseppe Guglielmini, Emanuela Falcinelli et autres

GATA2 is a transcription factor with key roles in hematopoiesis. Germline GATA2 gene variants have been associated with several inherited and acquired hematologic disorders, including myelodysplastic syndromes. Among the spectrum of GATA2 deficiency- associated manifestations thrombosis has been reported in 25% of …

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